6 results on '"Paul, M. J."'
Search Results
2. The survival paradox of elderly patients after major liver resections.
- Author
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IJtsma, Alexander J. C., Boevé, Liselotte M. S., van der Hilst, Christian S., de Boer, Marieke T., de Jong, Koert P., Peeters, Paul M. J. G., Gouw, Annet S. H., Porte, Robert J., Slooff, Maarten J. H., and Boevé, Liselotte M S
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HEALTH outcome assessment ,LIVER surgery ,OLDER patients ,HEALTH of older people ,HEALTH risk assessment of older people ,HEPATECTOMY ,LIVER tumors ,LONGITUDINAL method ,PROGNOSIS ,SURVIVAL ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,CASE-control method ,HOSPITAL mortality - Abstract
Objective: The objective of this study is to assess the outcome of liver resections in the elderly in a matched control analysis.Patients and Methods: From a prospective single center database of 628 patients, 132 patients were aged 60 years or over and underwent a primary major liver resection. Of these patients, 93 could be matched one-to-one with a control patient, aged less than 60 years, with the same diagnosis and the same type of liver resection. The mean age difference was 16.7 years.Results: Patients over 60 years of age had a significantly higher American Society of Anaesthesiologists (ASA) grade. All other demographics and operative characteristics were not different. In-hospital mortality and morbidity were higher in the patients over 60 years of age (11% versus 2%, p = 0.017 and 47% versus 31%, p = 0.024). One-, 3-, and 5-year survival rates in the patients over 60 years of age were 81%, 58%, and 42%, respectively, compared to 90%, 59%, and 42% in the control patients (p = 0.558). Unified model Cox regression analysis showed that resection margin status (hazard ratio 2.51) and ASA grade (hazard ratio 2.26), and not age, were determining factors for survival.Conclusion: This finding underlines the important fact that in patient selection for major liver resections, ASA grade is more important than patient age. [ABSTRACT FROM AUTHOR]- Published
- 2008
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3. YY1 Regulates the Neural Crest-associated slug Gene in Xenopus laevis.
- Author
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Morgan, Matthew J., Woltering, Joost M., In der Rieden, Paul M. J., Durston, Antony J., and Thiery, Jean Paul
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XENOPUS laevis , *NERVOUS system , *PIPIDAE , *EMBRYOLOGY , *CELL nuclei , *GENE expression , *GENETIC regulation , *CONNECTIVE tissues - Abstract
slug gene expression is associated with the specification and migration of neural crest cells in the African clawed frog Xenopus laevis. We provide evidence that the protein Ying-Yang 1 (YY1) regulates the slug gene expression both indirectly and directly, via a YY1 ciselement in the slug promoter, during Xenopus development. The ability of the YY1 to bind this YY1 cis-element was confirmed by electromobility shift assays and reporter assays. YY1 was detected in the nuclei of ectodermai cells contemporaneously with the process of neural crest specification. The injection of anti-YY1 morpholino, which targeted both YY1α and YY1β gene products, depleted YY1 expression below 20% and was lethal at gastrulation. Sublethal depletion of YY1 reduced the length of the anterior-posterior axis and severely inhibited the expression of the neural marker Nrp1 and of the slug gene. Overexpression of YY1 or mutation of the YY1 cis-element reduced the restricted spatial expression of the slug reporter gene in the neural ectoderm border and provoked its expression in the nonneural ectoderm. Chromatin immunoprecipitation indicated that endogenous YY1 interacts directly with the YY1 cis-element of the endogenous slug gene and with the slug gene reporter sequence injected into embryos. The results suggest that YY1 is essential for Xenopus development; is necessary for neural ectoderm differentiation, a prerequisite for neural crest specification; and restricts which cells can form neural crest mesenchyme through directly blocking slug gene activity. [ABSTRACT FROM AUTHOR]
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- 2004
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4. Enhanced Uptake of Ifosfamide into GH3 Prolactinomas with Hypercapnic Hyperoxic Gases Monitored in Vivo by [sup31]P MRS.
- Author
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Rodrigues, Loreta M., Robinson, Simon P., McSheehy, Paul M. J., Stubbs, Marion, and Griffiths, John R.
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PHARMACOKINETICS , *MAGNETIC resonance , *PHARMACODYNAMICS , *BLOOD flow - Abstract
Presents a study that examined pharmacokinetics and pharmacodynamics of fluorinated drugs through the use of magnetic resonance spectroscopy. Information on ifosfamide; Barriers that limit access of drugs to many parts of the tumor; Factors that have been used to increase tumor blood flow.
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- 2002
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5. Causes of discordant or negative ultrasound of parathyroid glands in treatment naïve patients with primary hyperparathyroidism.
- Author
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Chandramohan A, Sathyakumar K, Irodi A, Abraham D, Paul MJ, Chandramohan, Anuradha, Sathyakumar, Kirthi, Irodi, Aparna, Abraham, Deepak, and Paul, M J
- Abstract
Objectives: To describe causes of discordant or negative parathyroid ultrasound and to assess factors influencing them.Materials and Methods: Retrospective review of patients who underwent parathyroidectomy between 2000 and 2012 was done. Imaging findings were compared with operative findings and pathology to identify discrepant (n=60; 32 negative, 28 incorrect) parathyroid ultrasounds.Results: Fifty (83.3%) patients had parathyroid adenoma, of which 10 (16.6%) were ectopic and three were double adenomas; 8 (13.3%) had multigland hyperplasia and two had parathyroid carcinoma. Discrepant reports were due to incorrect localisation in 8 (13.3%); difficulty in differentiating thyroid from parathyroid lesion in 12 (20%); large and small size in two and three patients, respectively; overcall in 5 (8.3%) and satisfaction of search in 7 (11.7%) patients. There was significant correlation between presence of multi-nodular goitre and incorrect reports (χ(2)=4.112, p=0.04). Experience of ultrasound operators performing initial and second look ultrasound was significantly different (p<0.0001). Second look ultrasound was concordant with surgical findings in 39(65%) patients; 21 (66%) patients with initially negative ultrasound and four out of five extra-mediastinal ectopic lesions. Ten patients with negative initial ultrasound had elongated parathyroid lesion. Scintigraphy was concordant in 44 (73.3%) patients and nine were ectopic.Conclusion: Second look ultrasound performed by experienced operator for negative or discordant initial ultrasound of parathyroid is a useful strategy which will improve the accuracy of parathyroid ultrasound. Being able to differentiate thyroid from parathyroid lesion is a factor which will influence performance of parathyroid ultrasound. [ABSTRACT FROM AUTHOR]- Published
- 2012
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6. Tumor Interstitial Fluid Pressure as an Early-Response Marker for Anticancer Therapeutics.
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Ferretti, Stephane, Allegrini, Peter R., Becquet, Mike M., and McSheehy, Paul M. J.
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TUMORS , *BLOOD vessels , *BIOMARKERS , *DRUG therapy , *XENOGRAFTS , *LABORATORY mice - Abstract
Solid tumors have a raised interstitial fluid pressure (IFP) due to high vessel permeability, low lymphatic drainage, poor perfusion, and high cell density around the blood vessels. To investigate tumor IFP as an early-response biomarker, we have tested the effect of seven anticancer chemotherapeutics including cytotoxics and targeted cytostatics in 13 experimental tumor models. IFP was recorded with the wick-in-needle method. Models were either ectopic or orthotopic and included mouse and rat syngeneic as well as human xenografts in nude mice. The mean basal IFP was between 4.4 and 15.2mm Hg; IFP was lowest in human tumor xenografts and highest in rat syngeneic models. Where measured, basal IFP correlated positively with relative tumor blood volume (rTBV) determined by dynamic contrast-enhanced magnetic resonance imaging. Most chemotherapeutics sooner (2 or 3 days) or later (6 or 7 days) lowered tumor IFP significantly, and the cytotoxic patupilone caused the greatest decrease in IFP. In rat mammary orthotopic BN472 tumors, significant drug-induced decreases in IFP and rTBV correlated positively with each other for both patupilone and the cytostatic vatalanib. In the two orthotopic models studied, early decreases in IFP were significantly (P ≤ .005) correlated with late changes in tumor volume. Thus, drug-induced decreases in tumor IFP are an early marker of response to therapy, which could aid clinical development. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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