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Your search keyword '"Palao D"' showing total 33 results
Start Over Author "Palao D" Publisher elsevier b.v.
33 results on '"Palao D"'

26. Dynamical twisted mass fermions with light quarks

Author

Boucaud, Ph., Dimopoulos, P., Farchioni, F., Frezzotti, R., Gimenez, V., Herdoiza, G., Jansen, K., Lubicz, V., Martinelli, G., McNeile, C., Michael, C., Montvay, I., Palao, D., Papinutto, M., Pickavance, J., Rossi, G.C., Scorzato, L., Shindler, A., Simula, S., Urbach, C., and Wenger, U.

Published
2007
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28. Increased grey matter volumes in the temporal lobe and its relationship with cognitive functioning in euthymic patients with bipolar disorder.

Author

Porta-Casteràs, D., Vicent-Gil, M., Serra-Blasco, M., Navarra-Ventura, G., Solé, B., Montejo, L., Torrent, C., Martinez-Aran, A., De la Peña-Arteaga, V., Palao, D., Vieta, E., Cardoner, N., and Cano, M.

Subjects
*FUSIFORM gyrus, *TEMPORAL lobe, *VOXEL-based morphometry, *COGNITIVE ability, *BIPOLAR disorder, *MAGNETIC resonance imaging, *KIRKENDALL effect
Abstract

Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD patients may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructural alterations are related to the cognitive profile of BD is unclear. We aim to explore this relationship in euthymic BD patients with multimodal structural neuroimaging. A sample of 27 euthymic BD patients and 24 healthy controls (HC) underwent structural grey matter MRI and diffusion-weighted imaging (DWI). BD patient's cognition was also assessed. FreeSurfer algorithms were used to obtain estimations of regional grey matter volumes. White matter pathways were reconstructed using TRACULA, and four diffusion metrics were extracted. ANCOVA models were performed to compare BD patients and HC values of regional grey matter volume and diffusion metrics. Global brain measures were also compared. Bivariate Pearson correlations were explored between significant brain results and five cognitive domains. Euthymic BD patients showed higher ventricular volume (F(1, 46) = 6.04; p = 0.018) and regional grey matter volumes in the left fusiform (F(1, 46) = 15.03; pFDR = 0.015) and bilateral parahippocampal gyri compared to HC (L: F(1, 46) = 12.79, pFDR = 0.025/ R: F(1, 46) = 15.25, pFDR = 0.015). Higher grey matter volumes were correlated with greater executive function (r = 0.53, p = 0.008). We evaluated a modest sample size with concurrent pharmacological treatment. Higher medial temporal volumes in euthymic BD patients may be a potential signature of brain resilience and cognitive adaptation to a putative illness neuroprogression. This knowledge should be integrated into further efforts to implement imaging into BD clinical management. • Euthymic bipolar patients show higher grey matter volumes in the temporal lobe. • Higher grey matter volumes correlate with better executive function. • White matter metrics did not discriminate between patients and healthy participants. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Prefrontal-amygdala connectivity in trait anxiety and generalized anxiety disorder: Testing the boundaries between healthy and pathological worries.

Author

Porta-Casteràs, D, Fullana, MA, Tinoco, D, Martínez-Zalacaín, I, Pujol, J, Palao, DJ, Soriano-Mas, C, Harrison, BJ, Via, E, Cardoner, N, Fullana, M A, Palao, D J, and Harrison, B J

Subjects
*GENERALIZED anxiety disorder, *ANXIETY testing, *ANXIETY sensitivity, *PREFRONTAL cortex, *FUNCTIONAL magnetic resonance imaging, *FRONTAL lobe, *RESEARCH, *BASAL ganglia, *CROSS-sectional method, *RESEARCH methodology, *MAGNETIC resonance imaging, *EVALUATION research, *MEDICAL cooperation, *COMPARATIVE studies, *ANXIETY disorders, *ANXIETY
Abstract

Background: Current brain-based theoretical models of generalized anxiety disorder (GAD) suggest a dysfunction of amygdala-ventromedial prefrontal cortex emotional regulatory mechanisms. These alterations might be reflected by an altered resting state functional connectivity between both areas and could extend to vulnerable non-clinical samples such as high worriers without a GAD diagnosis. However, there is a lack of information in this regard.Methods: We investigated differences in resting state functional connectivity between the basolateral amygdala and the ventromedial prefrontal cortex (amygdala-vmPFC) in 28 unmedicated participants with GAD, 28 high-worriers and 28 low-worriers. We additionally explored selected clinical variables as predictors of amygdala-vmPFC connectivity, including anxiety sensitivity.Results: GAD participants presented higher left amygdala-vmPFC connectivity compared to both groups of non-GAD participants, and there were no differences between the latter two groups. In our exploratory analyses, concerns about the cognitive consequences of anxiety (the cognitive dimension of anxiety sensitivity) were found to be a significant predictor of the left amygdala-vmPFC connectivity.Limitations: The cross-sectional nature of our study preclude us from assessing if functional connectivity measures and anxiety sensitivity scores entail an increased risk of GAD.Conclusions: These results suggest a neurobiological qualitative distinction at the level of the amygdala-vmPFC emotional-regulatory system in GAD compared to non-GAD participants, either high- or low-worriers. At this neural level, they question previous hypotheses of continuity between high worries and GAD development. Instead, other anxiety traits such as anxiety sensitivity might confer a greater proneness to the amygdala-vmPFC connectivity alterations observed in GAD. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Dynamical twisted mass fermions with light quarks: simulation and analysis details

Author

Boucaud, Ph., Dimopoulos, P., Farchioni, F., Frezzotti, R., Gimenez, V., Herdoiza, G., Jansen, K., Lubicz, V., Michael, C., Münster, G., Palao, D., Rossi, G.C., Scorzato, L., Shindler, A., Simula, S., Sudmann, T., Urbach, C., and Wenger, U.

Subjects
*PERTURBATION theory, *ALGORITHMS, *STATISTICAL correlation, *QUARKS, *PARTICLES (Nuclear physics)
Abstract

Abstract: In a recent paper [ETMC, P. Boucaud et al., Phys. Lett. B 650 (2007) 304, hep-lat/0701012] we presented precise lattice QCD results of our European Twisted Mass Collaboration (ETMC). They were obtained by employing two mass-degenerate flavours of twisted mass fermions at maximal twist. In the present paper we give details on our simulations and the computation of physical observables. In particular, we discuss the problem of tuning to maximal twist, the techniques we have used to compute correlators and error estimates. In addition, we provide more information on the algorithm used, the autocorrelation times and scale determination, the evaluation of disconnected contributions and the description of our data by means of chiral perturbation theory formulae. [Copyright &y& Elsevier]

Published
2008
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