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139,624 results on '"P R"'

1. Bayesian tuning of the Compact Muon Beam Line for the Mu3e experiment

Author: Dal Maso, G., Kettle, P.- R., Knecht, A., Leonetti, F., Lospalluto, G., Papa, A., and Valetov, E.
Published: 2024
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2. Facile synthesis of samarium (Sm3+) doped cobalt-iron oxide nano ferrite as an advanced electrode material for possible supercapacitor applications

Author: Khasim, Syed, Pasha, Apsar, Ramakrishna, B.N., B.S, Prathibha, and P. R, Koushalya
Published: 2024
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3. CNN based plant disease identification using PYNQ FPGA

Author: Perumal, Vivek Karthick, T, Supriyaa, P R, Santhosh, and S, Dhanasekaran
Published: 2024
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4. Update on 18F-Fluoroestradiol.

Author: O'Brien, Sophia R., Edmonds, Christine E., Ward, Rebecca E., Taunk, Neil K., Pantel, Austin R., and Mankoff, David A.
Abstract: 18F-16α-Fluoroestradiol (18F-FES) is a radiolabeled estrogen analogue positron emission tomography (PET) imaging agent that binds to the estrogen receptor (ER) in the nucleus of ER-expressing cells. Proof-of-concept studies of 18F-FES demonstrated expected correlation between tumoral 18F-FES-positivity on PET-imaging and ER+ status assessed on biopsy samples by radioligand binding and immunohistochemistry. After decades of study, 18F-FES PET/CT gained clinical approval in 2016 in France and 2020 in the United States for use in patients with ER+ metastatic or recurrent breast cancer. ER+ as assessed by 18F-FES PET/CT has been shown to serve as a biomarker, identifying metastatic breast cancer patients who may respond to endocrine therapy and those who are unlikely to respond. In 2023, the Society of Nuclear Medicine and Molecular Imaging (SNMMI) published Appropriate Use Criteria for 18F-FES PET/CT, identifying four indications in which use of 18F-FES PET/CT was "appropriate": (1) To assess functional ER status in metastatic lesions unfavorable to biopsy or when biopsy is nondiagnostic, (2) To detect ER status when other imaging tests are equivocal or suspicious, and at (3) initial diagnosis of metastatic disease or (4) progression of metastatic disease, for considering endocrine therapy. This article reviews the foundations of 18F-FES imaging, including normal distribution, false positives, and false negatives, and describes the most up-to-date clinical uses as well as emerging research in breast cancer and other patient populations. [ABSTRACT FROM AUTHOR]
Published: 2024
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5. Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT).

Author: Williams, Michelle C., Weir-McCall, Jonathan R., Baldassarre, Lauren A., De Cecco, Carlo N., Choi, Andrew D., Dey, Damini, Dweck, Marc R., Isgum, Ivana, Kolossvary, Márton, Leipsic, Jonathon, Lin, Andrew, Lu, Michael T., Motwani, Manish, Nieman, Koen, Shaw, Leslee, van Assen, Marly, and Nicol, Edward
Published: 2024
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6. Determinants of compliance with infection prevention measures by physicians: a scoping review.

Author: Schutte, M., van Mansfeld, R., de Vries, R., and Dekker, M.
Abstract: Despite evidence that application of infection prevention measures can reduce healthcare-associated infections, compliance with these measures is low, especially among physicians. Intervention effects often do not sustain. An overview of determinants for physicians' infection prevention behaviour and successful behaviour change strategies is lacking. The aim of this review was to identify what determinants influence physicians' infection prevention behaviour, what strategies to improve compliance have been explored, and whether theories, models, and frameworks from implementation science have been used in these studies. A literature search was performed in PubMed, Embase, APA PsycInfo and Web of Science up to June 2nd, 2023, in collaboration with a medical information specialist. All study types focusing on infection prevention behaviour of physicians in high-income countries were included. Data on determinants and strategies was extracted; determinants were categorized into the Theoretical Domains Framework (TDF). Fifty-six articles were included. The TDF domains 'environmental context and resources', 'social influences', 'beliefs about consequences', 'memory, attention and decision-making', 'knowledge', and 'skills' were found most relevant. The prevailing determinant covers a theme outside the TDF: socio-demographic factors. Sustainable interventions are multimodal approaches that at least include feedback, education, and a champion. Theories, models, and frameworks have rarely been used to guide implementation strategy development. In conclusion, it was found that intervention studies rarely specify the determinants that they aim to address and they lack theoretical underpinning. Future initiatives should combine knowledge about determinants with implementation science to develop theory-based interventions tailored to determinants. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Acanthamoebae as a protective reservoir for Pseudomonas aeruginosa in a clinical environment.

Author: Mooney, R., Richardson, K., Rodgers, K., Giammarini, E., Williams, R., Kelly, S., Amaeze, N., Inkster, T., Henriquez, F.L., and Mackay, W.
Abstract: Pseudomonas aeruginosa is a growing concern in healthcare-associated infections and poses significant risk to those with serious underlying health conditions. The antimicrobial resistance traits of the pathogen and ability to form biofilms make effective mitigation and disinfection strategies difficult. Added to this challenge is the role that free-living amoebae such as Acanthamoeba play in the detection, disinfection and transmission of P. aeruginosa. P. aeruginosa can survive intracellularly within amoebae, which has the potential to limit detectability and permit transmission into high-risk areas. We screened for the presence of Acanthamoeba spp. and P. aeruginosa within a functioning general hospital in Scotland using a culture and molecular approach, noting their presence at several sites over a four-month period, particularly within floor drains connecting patient rooms. In addition, microbiome analysis revealed that amoebae harbour a unique microbial community comprised primarily of Pseudomonas spp. that were not readily detected using microbiome sequencing techniques on environmental swabs. Having demonstrated that both organisms were consistently present in hospital settings, we investigated the relationship between acanthamoeba and P. aeruginosa in the laboratory , showing that (i) acanthamoeba growth rate is increased in the presence of pseudomonas biofilms and viable pseudomonas persist within the amoebae and (ii) hydrogen peroxide-based disinfectants are significantly less effective against an isolate of P. aeruginosa in the presence of acanthamoeba than when the bacteria are incubated alone. These findings suggest that amoebae, and other protists, can influence the detection and persistence of P. aeruginosa in high-risk areas and should be considered when implementing mitigation strategies. [ABSTRACT FROM AUTHOR]
Published: 2024
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8. PSI: Planner-specific, physician-specific, or patient-specific implant for orbital reconstruction?

Author: Sabelis, J.F., Shaheen, E., Willaert, R., Becking, A.G., Dubois, L., and Schreurs, R.
Subjects: EYE-socket fractures, COMPUTER-aided design, COMPUTER-assisted surgery, ENGINEERS, INDIVIDUALIZED medicine
Abstract: This study aimed to identify and quantify the variations in PSI designs intended for an identical patient. Records from 10 patients with an orbital fracture involving two walls, for which a primary orbital reconstruction was indicated, were retrospectively included. Clinical engineers from two centers independently generated proposal designs for all patients. Following web meeting(s) with the surgeon from the same institute, the PSI designs were finalized by the engineer. A cross-over of the engineer with the surgeon of the other center created two new design teams. In total, 20 proposal and 40 final PSI designs were produced. A three-dimensional comparison between different PSI designs for the same patient was performed by computing a difference score. Initially, the design proposals of the two engineers showed a median difference score of 37%, which was significantly reduced to a median difference score of 26% for the final designs with different engineers. The median difference score of 22% between surgeons demonstrated that both parties introduced notable user variations to the final designs. Evidence supporting the advantages of an experienced design team was found, with significantly fewer modifications, fewer meetings, and less time required to complete the design (up to 40% time reduction). The findings of the study underline the dependency of PSI design on the surgeon and engineer, and support the need for a more evidence-based protocol for PSI design. [ABSTRACT FROM AUTHOR]
Published: 2024
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9. Through their eyes: Navigating life with limited eyelid closure in patients with Moebius syndrome.

Author: Mulenga, Chilando M., Tran, Khoa D., Jorge, Miguel D., Crabtree, Jordan R., Henriquez, Mario A., Boente, Charline S., Meanwell, Emily V., Zuker, Ronald M., Bogart, Kathleen R., and Borschel, Gregory H.
Abstract: Moebius syndrome (MoS), a rare congenital condition caused by the underdevelopment of the sixth and seventh cranial nerves, presents with uni- or bilateral facial paralysis and lateral gaze palsy. Those with MoS often have incomplete eyelid closure (lagophthalmos). This study aimed to investigate the experiences of individuals living with incomplete eyelid closure due to MoS. Participants shared their experiences in semi-structured open-ended focus groups during the 2023 MoS Foundation Conference. Data were analyzed thematically using Nvivo. The Terzis and Bruno scoring system was used to grade participant eyelid closure (range: 1 being no eyelid closure with full scleral show to 5 being complete eyelid closure with no scleral show) and blink (from 1 being no blink to 5 being synchronous and complete blink present). Marginal reflex distances 1 and 2 (MRD1 and MRD2) were measured to grade for ptosis and lid retraction, respectively. Fifteen participants participated in two focus groups, comprising adults (n = 12) and adolescents (n = 3). All participants had lagophthalmos with some scleral show, ptosis, and lid retraction. The median eyelid closure score was 3 (incomplete eye closure with 1/3 scleral showing). Five key themes were identified: social stigma and misunderstanding, daily life impacts, seasonal exacerbations, different attitudes toward surgical intervention between adults and adolescents, and a prevailing sense of self-acceptance regarding their condition. Incomplete eyelid closure poses significant social challenges for individuals with MoS, especially around social encounters. Our findings show the importance of developing tailored communication tools to support those living with this facial difference. [ABSTRACT FROM AUTHOR]
Published: 2024
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10. Biochemical Relapse-Free Survival in Postprostatectomy Patients Receiving 18F-Fluciclovine-Guided Prostate Bed-Only Radiation: Post Hoc Analysis of a Prospective Randomized Trial.

Author: Dhere, Vishal R., Schuster, David M., Goyal, Subir, Schreibmann, Eduard, Hershatter, Bruce W., Patel, Sagar A., Shelton, Joseph W., Hanasoge, Sheela, Patel, Pretesh R., Sebastian, Nikhil T., Adediran, Omotayo A., Lawal, Ismaheel O., and Jani, Ashesh B.
Abstract: Whole-pelvis (WP) radiation therapy (radiation) improved biochemical relapse-free survival (bRFS) compared with prostate bed (PB)-only radiation in the Radiation Therapy Oncology Group 0534, but was performed in an era prior to positron emission tomography (PET) staging. Separately, 18F-fluciclovine PET/CT-guided postprostatectomy radiation improved 3-year bRFS versus radiation guided by conventional imaging alone. We hypothesized that patients who were changed from WP to PB-only radiation after PET would have bRFS that was: (a) no higher than patients initially planned for PB-only radiation; and (b) lower than patients planned for WP radiation without PET guidance. We conducted a post hoc analysis of a prospective, randomized trial comparing conventional (arm 1) versus PET-guided (arm 2) postprostatectomy radiation. In arm 2, pre-PET treatment field decisions were recorded and post-PET fields were defined per protocol; pathologic node negative (pN0) without pelvic or extrapelvic PET uptake received PB-only radiation. Three-year bRFS was compared in patients planned for WP with change to PB-only radiation (arm 2 [WP:PB]) vs arm 2 patients planned for PB-only with final radiation to PB-only (arm 2 [PB:PB]) and arm 1 pN0 patients treated with WP radiation (arm 1 [WP]) using the Z test and log-rank test. Demographics were compared using the chi-square test, Fisher exact test, or analysis of variance, as appropriate. We identified 10 arm 2 (WP:PB), 31 arm 2 (PB:PB) and 11 arm 1 (WP) patients. Androgen deprivation was used in 50.0% of arm 2 (WP:PB) and 3.2% of arm 2 (PB:PB) patients, P <.01. Median preradiation prostate-specific antigen was higher in arm 2 (WP:PB) vs arm 2 (PB:PB) patients (0.4 vs 0.2 ng/mL, P =.03); however, there were no significant differences in T stage, Gleason score, or margin positivity. Three-year bRFS was 80% in arm 2 (WP:PB) vs 87.4% in arm 2 (PB:PB), P =.47, respectively. Arm 1(WP) patients had significantly worse 3-year (23%) bRFS vs arm 2 (WP:PB), P <.01. Patients initially planned for WP radiation with field decision change to PB-only radiation after PET showed (1) no significant difference in 3-year bRFS compared with patients initially planned for PB-only radiation; and (2) improved bRFS compared with patients receiving WP radiation without PET guidance. PET-guided volume de-escalation in selected patients may be 1 approach to mitigating toxicity without compromising outcomes. [ABSTRACT FROM AUTHOR]
Published: 2024
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11. Order From Chaos: The Benefits of Standardized Nomenclature in Radiation Oncology.

Author: Richardson, Susan L., Bosch, Walter R., Mayo, Charles S., McNutt, Todd R., Moran, Jean M., Popple, Richard A., Xiao, Ying, and Covington, Elizabeth L.
Abstract: Although standardization has been shown to improve patient safety and improve the efficiency of workflows, implementation of standards can take considerable effort and requires the engagement of all clinical stakeholders. Engaging team members includes increasing awareness of the proposed benefit of the standard, a clear implementation plan, monitoring for improvements, and open communication to support successful implementation. The benefits of standardization often focus on large institutions to improve research endeavors, yet all clinics can benefit from standardization to increase quality and implement more efficient or automated workflow. The benefits of nomenclature standardization for all team members and institution sizes, including success stories, are discussed with practical implementation guides to facilitate the adoption of standardized nomenclature in radiation oncology. [ABSTRACT FROM AUTHOR]
Published: 2024
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12. Disparities Based on Demographic Features in the Intensity and Treatment of Chronic Pain in US Patients With Spinal Cord Injury.

Author: Wild, Marcus G., Ehde, Dawn M., Reyes, Maria R., Fann, Jesse R., and Bombardier, Charles H.
Abstract: Informed by Minority Stress Theory, to investigate disparities in pain intensity, interference, and care in patients with spinal cord injuries (SCI) based on demographic features. Cross-sectional survey. Outpatient SCI clinics in 2 academic medical centers in the northwestern United States. Sample of 242 SCI clinic patients who endorsed SCI-related pain, were ≥18-years-of-age, English-fluent, not diagnosed with bipolar or psychotic disorders, and able to make their own medical decisions. Participants were 74.8% men, an average of 48.5 years (range 18.1-89.8 years), 76.2% White, 31.9% privately insured, and 64.7% making <$50,000 per year. Not applicable. Exploratory analyses of screening data from a randomized controlled trial for pain treatment. Primary outcomes included pain intensity, pain interference, and the patient report of recommended pain treatments by a medical provider, tried by the patient, or that the patient would be willing to try. More treatments recommended was associated with younger age (ρ=−0.14, 95% confidence interval [CI]: −0.01 to −0.27, P =.03) and private insurance (ρ=-0.15, 95% CI: 0.02-0.27, P =.03), whereas more treatments tried was associated with private insurance alone (ρ=0.20, 95% CI: 0.07-0.32, P =.003). Number of treatments willing to be tried was associated with lower income (ρ=−0.15, 95% CI: −0.02 to −0.28, P =.03). SCI patients of color (PoC) reported higher pain intensity (Cohen's d =0.41, 95% CI: 0.11-0.71) and greater odds of receiving psychotherapy for pain (odds ratio: 7.12, 95% CI: 1.25-40.46) than their White peers. These exploratory findings indicate differences in SCI-related pain intensity based on identifying as PoC, and differences in SCI-related pain treatment modalities based on identifying as PoC, age, insurance type, and income. Further work exploring differences in SCI-related pain care based on patient social identities is warranted. [ABSTRACT FROM AUTHOR]
Published: 2024
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13. Most cutaneous squamous cell carcinoma recurrences occur in the first 3 years after diagnosis: A multicenter retrospective cohort study.

Author: Granger, Emily E., Ran, Nina A., Groover, Morgan K., Koyfman, Shlomo A., Vidimos, Allison T., Wysong, Ashley, Carr, David R., Shahwan, Kathryn T., Hirotsu, Kelsey E., Carucci, John A., Carter, Joi B., Cañueto, Javier, Girardi, Fabio Muradás, Mangold, Aaron R., Srivastava, Divya, Brodland, David G., Zitelli, John A., Willenbrink, Tyler J., and Ruiz, Emily S.
Published: 2024
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14. Real-world experience of bimekizumab for adult patients with plaque psoriasis: A 52-week multicenter retrospective study.

Author: Sood, Siddhartha, Rimke, Alexander, Rankin, Brian D., Abduelmula, Abrahim, Georgakopoulos, Jorge R., Maliyar, Khalad, Bagit, Ahmed, Leung, Fernejoy, Stark, Lauren A., Devani, Alim R., Vender, Ronald, Yeung, Jensen, and Prajapati, Vimal H.
Published: 2024
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15. Cost-effectiveness of patch testing allergens within the same group: A computational approach to optimize formaldehyde-related allergen selection.

Author: McKenzie, Ning C., Buras, Matthew R., Yiannias, James A., Hall, Matthew R., Youssef, Molly J., Davis, Mark D.P., and Yang, Yul W.
Abstract: Patch testing for multiple cross-reactive allergens for allergic contact dermatitis (ACD) may not be necessary because of copositivity. We evaluated the formaldehyde group allergens to determine the optimal, most cost-effective allergens to test. A retrospective analysis of Mayo Clinic (1997-2022) examined the well-established copositive formaldehyde group: formaldehyde, quaternium 15, hexahydro-1,3,5-tris(2-hydroxyethyl)triazine, diazolidinyl urea, imidazolidinyl urea, toluenesulphonamide formaldehyde resin, DMDM hydantoin, and ethyleneurea melamine formaldehyde mix. Patch Optimization Platform identified which single formaldehyde-related allergen optimally captures patients with clinically relevant ACD. Next, Patch Optimization Platform determined the optimal additional 1, 2, 3, etc. allergens. Cost per patch test was $5.19 (Medicare 2022). A total of 9832 patients were tested for all listed allergens, with 830 having positive patch test results. Patch Optimization Platform determined that quaternium 15 alone captures 53% of patients with ACD to the formaldehyde group; adding the optimal second allergen (formaldehyde 1%) captures 78%; the optimal 5 top allergens capture >94% of patients. The incremental cost per additional diagnosis increased up to 44-fold as the number of allergens tested increased. Data are from a single institution, and the cost per test was fixed according to Medicare Part B in 2022. For diagnosing ACD, we recommend considering an optimized allergen selection algorithm. [ABSTRACT FROM AUTHOR]
Published: 2024
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16. Survivorship and Patient Outcomes of Conforming Bearings in Modern Primary Total Knee Arthroplasty: Mean 3.5 Year Follow-Up.

Author: Patel, Sohum K., Buller, Leonard T., Deckard, Evan R., and Meneghini, R. Michael
Abstract: The use of conforming and congruent bearings in total knee arthroplasty (TKA) have rapidly increased due to the benefits of increased stability and the potential for replicating normal knee kinematics. However, limited data exist for these newly available bearings. This study evaluated revision-free survivorship and patient-reported outcome measures (PROMs) of a large granular database of primary TKAs using a single conforming bearing design. A total of 1,306 consecutive primary TKAs performed using a single conforming bearing design (85% cemented and 15% cementless) were retrospectively reviewed. Kaplan-Meier survivorship estimates were calculated based on the latest clinical follow-up. The PROMs and minimal clinically important differences were evaluated. A total of 93% of cases achieved minimum 1-year clinical follow-up (mean 3.5 years; range, 1 to 7), with a subset of 261 cases that achieved minimum 5-year follow-up (mean 5.8 years; range, 5 to 7). All-cause and aseptic Kaplan-Meier survivorship estimates were 97.6 (95% CI [confidence interval], 97 to 99) and 98.1% (95% CI, 97 to 99) at 7.0 years. Revision-free survivorship did not differ by cemented or cementless fixation (98 versus 97%, P =.163). All PROM scores significantly improved from preoperative baseline (P <.001), and ≥ 86% of patients achieved minimal clinically important differences for Knee Society pain and Knee Injury and Osteoarthritis Outcome Score for Joint Replacement total scores. A total of 89% of cases reported their knees to 'sometimes or always' feel normal. For cases with minimum 5-year PROMs, 93% were 'very satisfied' or 'satisfied.' Conforming-bearing TKA demonstrated excellent survivorship up to 7.0 years. In addition, PROMs were comparable to other designs reported in the literature. While mid-term (mean 3.5-year) results are promising, long-term data are warranted on survivorship due to potential polyethylene wear in conforming bearings with more surface area in contact with articulating surfaces. IV. [ABSTRACT FROM AUTHOR]
Published: 2024
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17. Continued improvement to imaging diagnosis and treatment triage of endometriosis: The role of the multi-disciplinary conference.

Author: Consul, Nikita, Haber, Hilary R., Movilla, Peter R., Harisinghani, Mukesh G., Kambadakone, Avinash, Kilcoyne, Aoife, and Shenoy-Bhangle, Anuradha S.
Abstract: Patient-centered endometriosis management tailored to the individual patient's subset of symptoms often requires highly sensitive and specific preoperative imaging. In the setting of a present ongoing learning curve among radiologists who interpret pelvis ultrasounds and MRIs for diagnosis of endometriosis, we have found that routine feedback between minimally invasive gynecology surgeons and radiologists, based on pre-operative imaging and postoperative laparoscopic findings, is essential for the continual improvement of imaging-based staging of endometriosis and empower pre-operative imaging as an important pillar of endometriosis management. We share illustrative patient cases, which, after collaborative discussion during our routine multi-institutional, multi-disciplinary conferences (MDCs) have led to improved patient counseling, better pre-surgical planning, and therefore improved patient satisfaction. Our endometriosis MDCs will continue to improve patient management in the future by providing a forum for trainees in medical, surgical, imaging, and pathology specialties to gain expertise directly from subspecialists, and participate in the care of these patients. [ABSTRACT FROM AUTHOR]
Published: 2024
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18. The roles and responsibilities of advanced practice nurses in intensive care units: A scoping review.

Author: Jafari Pour, F., Watson, R., Jafaripour, E., and Jafarian, R.
Published: 2024
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19. Cardiac SABR: Image matching techniques for accurate treatment delivery.

Author: Brooks-Pearson, R., Pilling, K., Ormston, B., MacKenzie, L., Huntley, C., Kerr, A., Crouch, R., Richmond, N., van der Putten, M., and Atherton, P.
Abstract: Ventricular tachycardia is an irregular heartbeat conventionally treated using invasive cardiac catheter ablation and medication. However, when standard treatments have been exhausted, cardiac SABR provides a final treatment option to this high-mortality condition. Complex diagnostic mapping and planning scans enable multi-disciplinary target delineation for a 25Gy single fraction. However, organs at risk (OAR) near the target make this treatment challenging to plan and deliver. Publications from cardiologists report the efficacy of cardiac SABR, however there is limited data on the treatment delivery and image matching of this complex procedure. Four specialist therapeutic radiographers experienced in cardiac SABR reviewed 40 CBCTs from 10 patients treated in the UK. Each therapeutic radiographer conducted five image matches: a manual match (manual), an automatic match to the heart structure (auto) and the auto match followed by manual adjustment to the PTV (PTV), all using three degrees of freedom (DoF) only. The auto and PTV matches were also repeated using 6DoF. Inter-observer variability was quantified using 95% limits of agreement from a modified Bland-Altman analysis. The limits of agreement were smallest in the automatic matches suggesting the algorithm is reliable. A manual adjustment from the auto match to the PTV is clinically appropriate to optimise target coverage. The limits of agreement were smaller in the 6DoF PTV match 1.06 mm, 1.24 mm, 1.68 mm than the 3DoF PTV match 1.57 mm, 2.06 mm, 2.11 mm (lateral, vertical, longitudinal). The 6DoF CBCT image match has less variability and therefore suggest using a 6DoF couch for treatment delivery. Cardiac SABR CBCT image matching at treatment delivery is complex, optimisation of CBCT acquisition parameters and therapeutic radiographer training is essential prior to implementation. [ABSTRACT FROM AUTHOR]
Published: 2024
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20. Lateglacial Interstadial to mid-Holocene stratigraphy and palynology at Pepper Arden Bottoms, North Yorkshire, UK.

Author: Innes, James B., Rutherford, Mairead M., Bridgland, David R., Gearey, Ben R., Lillie, Malcolm C., Mitchell, Wishart A., O'Brien, Charlotte E., Jones, Richard T., and Thompson, Gareth J.
Abstract: Investigations at Pepper Arden Bottoms, a lake basin site on the interfluve between the rivers Tees and Swale in northeast England, have recovered lithostratigraphical, pollen and plant macrofossil sequences which have allowed the reconstruction of sedimentary and vegetation history from the Lateglacial Interstadial to the post- Ulmus Decline mid-Holocene. Although the calcareous nature of the sediment and lack of terrestrial plant macrofossils precluded radiocarbon dating of sediments pre-dating the Ulmus Decline, pollen analyses showed sediment accumulation from the middle of the Lateglacial Interstadial, with the lake catchment remaining poorly vegetated until the Holocene, with low values for woody taxa, and grasses and sedges dominant. The late Interstadial cold phase GI-1b is present in the pollen stratigraphy, with a major reduction in Betula frequencies, replaced by Juniperus , and an increase in cold-tolerant herbs, mainly grasses and sedges. Microcharcoal frequencies are consistently substantial throughout the Lateglacial levels, probably indicating a natural fire regime, but are absent from the Holocene, suggesting little Mesolithic or Neolithic activity nearby, which is confirmed by a lack of pollen indicators of disturbance. The Lateglacial (Loch Lomond) Stadial is entirely dominated by Cyperaceae and Poaceae pollen, with very few trees and shrubs. The successive migration of postglacial thermophilous trees is recorded in the Holocene and possible effects of the Preboreal Oscillation and the 8.2 ka BP cold events are recognised. An Ulmus Decline occurs near the top of the profile, after which the assemblage is dominated by Alnus as the lake became terrestrialised and was occupied by fen and then alder carr. The very open Lateglacial vegetation adds this site to a northern group in northeast England with poor Lateglacial woodland development, in contrast to sites to the south, in North Yorkshire, where Lateglacial Betula woodland was much better established. [ABSTRACT FROM AUTHOR]
Published: 2024
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21. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of chronic pancreatitis: summary and recommendations.

Author: Sheth, Sunil G., Machicado, Jorge D., Chalhoub, Jean M., Forsmark, Christopher, Zyromski, Nicholas, Thosani, Nirav C., Thiruvengadam, Nikhil R., Ruan, Wenly, Pawa, Swati, Ngamruengphong, Saowanee, Marya, Neil B., Kohli, Divyanshoo R., Fujii-Lau, Larissa L., Forbes, Nauzer, Elhanafi, Sherif E., Desai, Madhav, Cosgrove, Natalie, Coelho-Prabhu, Nayantara, Amateau, Stuart K., and Alipour, Omeed
Abstract: This clinical practice guideline from the American Society for Gastrointestinal Endoscopy (ASGE) provides an evidence-based approach for the role of endoscopy in the management of chronic pancreatitis (CP). This document was developed using the Grading of Recommendations Assessment, Development and Evaluation framework. The guideline addresses effectiveness of endoscopic therapies for the management of pain in CP, including celiac plexus block, endoscopic management of pancreatic duct (PD) stones and strictures, and adverse events such as benign biliary strictures (BBSs) and pseudocysts. In patients with painful CP and an obstructed PD, the ASGE suggests surgical evaluation in patients without contraindication to surgery before initiation of endoscopic management. In patients who have contraindications to surgery or who prefer a less-invasive approach, the ASGE suggests an endoscopic approach as the initial treatment over surgery, if complete ductal clearance is likely. When a decision is made to proceed with a celiac plexus block, the ASGE suggests an EUS-guided approach over a percutaneous approach. The ASGE suggests indications for when to consider ERCP alone or with pancreatoscopy and extracorporeal shock wave lithotripsy alone or followed by ERCP for treating obstructing PD stones based on size, location, and radiopacity. For the initial management of PD strictures, the ASGE suggests using a single plastic stent of the largest caliber that is feasible. For symptomatic BBSs caused by CP, the ASGE suggests the use of covered metal stents over multiple plastic stents. For symptomatic pseudocysts, the ASGE suggests endoscopic therapy over surgery. This document clearly outlines the process, analyses, and decision processes used to reach the final recommendations and represents the official ASGE recommendations on the above topics. [ABSTRACT FROM AUTHOR]
Published: 2024
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22. Contemporary disparities in progression to orchiopexy for cryptorchidism as reported in the Pediatric Health Information System (PHIS) database.

Author: Siegal, Alexandra R., Mbaye, Farimata, Chin, Chih Peng, Ferrer, Fernando A., Malhotra, Neha R., and Makari, John H.
Abstract: When evaluating the timeliness of orchiopexy for cryptorchidism, health disparities are apparent among Hispanic and African American males and those with public insurance. Since the publication of these data, the COVID-19 pandemic has stressed our healthcare system and significantly affected the provision of pediatric urology care. We sought to assess if certain groups were disproportionately affected in progression to orchiopexy after the diagnosis of cryptorchidism during and after the pandemic in US freestanding children's hospitals. Using the PHIS database, pediatric patients ≤5 years who underwent orchiopexy between January 2018 and December 2022 were retrospectively analyzed. Exclusion criteria included prematurity, retractile testes, and testicular torsion. Primary outcomes were age at orchiopexy and the proportion of individuals undergoing timely orchiopexy for cryptorchidism. Over the study period 3140 patients ≤5 years old underwent orchiopexy for cryptorchidism. Non-Hispanic Blacks and Hispanics were significantly less likely to have timely orchiopexy and underwent orchiopexy 2.13 and 3.60 months later compared to whites (p < 0.01). As compared to pre-COVID-19, during the pandemic the proportion of patients who had timely surgery was higher and the median age was significantly lower (p = 0.01 and p < 0.01, respectively) in white patients only. Over the study period, patients with public insurance were less likely to have timely orchiopexy and underwent orchiopexy 2.94 months later (p < 0.01) than patients with private insurance. Compared to during the pandemic, post-pandemic a significantly lower proportion of publicly insured patients have since undergone timely orchiopexy (p = 0.04). Patients in the West were less likely to have timely orchiopexy and had a higher age at time of orchiopexy (p < 0.01) than other regions. However, in the West during the pandemic, the proportion of children who had timely surgery was higher compared to pre-and post-COVID-19 (p < 0.01). Overall, regardless of insurance status, race, or location, a significant proportion of patients did not undergo timely orchiopexy. During the pandemic white patients had a lower median age and an increased proportion underwent timely orchiopexy, despite the number of orchiopexies remaining constant. Disparities in the post-COVID-19 era have been further exacerbated for publicly insured patients, who a significantly lower proportion of have since undergone timely orchiopexy. Specific efforts are required across the United States to increase timely orchiopexy for all boys. Progression to timely orchiopexy remains low for all boys in the era surrounding COVID-19; certain groups appear to be more adversely affected. [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2024
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23. The quality of antimicrobial prescribing in skin and soft tissue management in Australian hospitals: an analysis of the National Antimicrobial Prescribing Survey data.

Author: Park, S., Thursky, K., Zosky-Shiller, L., James, R., Cheah, R., Hall, L., and Ierano, C.
Abstract: Skin and soft tissue infections (SSTIs) are among the most common indications for antimicrobial prescribing in hospitals. Inappropriate antimicrobial use can lead to increased morbidity, unnecessary hospital re-admission and increased antimicrobial resistance. This study aimed to assess the quality of antimicrobial prescribing practices in SSTI management within Australian hospitals to provide guidance for future practice. A retrospective analysis was conducted with data from the National Antimicrobial Prescribing Survey (NAPS). SSTI prescribing data from Hospital NAPS (2013–2022) and surgical site infection data from Surgical NAPS (2016–2022) datasets were analysed. Variables assessed included guideline compliance, appropriateness as per the structured NAPS algorithm, and reasons for inappropriateness. From the Hospital NAPS dataset, 40,535 antimicrobial prescriptions for SSTIs were analysed. The most common indication was cellulitis (34.1%, N =13,822), and the most prescribed antimicrobial was flucloxacillin (18.8%, N =7,638). SSTI indications had a lower rate of guideline compliance but a higher rate of appropriateness compared with all other indications for antimicrobial prescriptions (guideline compliance 66.3%, N =21,035 vs 67.4%, N =156,285; appropriateness 75.6%, N =30,639 vs 72.7%, N =209,383). The most common reason for inappropriateness was incorrect dose or frequency (29.3%, N =2367). From the Surgical NAPS dataset, 5674 prescriptions for surgical site infections were analysed. Of these, 68.2% (N =3867) were deemed to be appropriate. The most common reason for inappropriateness was incorrect dose or frequency (27.7%, N =350). As SSTIs are a common indication for prescribing an antimicrobial in Australian hospitals, identifying effective antimicrobial stewardship strategies to optimize antimicrobial use for SSTI management is recommended to improve patient outcomes. [ABSTRACT FROM AUTHOR]
Published: 2024
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24. Targeted muscle reinnervation at the time of amputation to prevent the development of neuropathic pain.

Author: Raasveld, Floris V., Mayrhofer-Schmid, Maximilian, Johnston, Benjamin R., Gomez-Eslava, Barbara, Hoftiezer, Yannick A.J., Liu, Wen-Chih, Valerio, Ian L., and Eberlin, Kyle R.
Abstract: Targeted muscle reinnervation (TMR) is an established modality for the surgical management of neuropathic pain. Although the preventive effect of primary (acute) TMR at the time of amputation has been demonstrated previously, it remains unclear how many and which patients benefit most. Therefore, this study investigated the proportion of patients achieving sustained pain prophylaxis following amputation, as well as factors associated with its efficacy. Primary patients who underwent TMR with a minimum follow-up of 6 months between 2018 and 2023 were enrolled. Pain outcomes (numeric rating scale [NRS], 0–10), comorbidities, and surgical factors were collected from chart review. Patients achieving sustained pain prophylaxis (NRS of ≤3 for ≥3 months until final follow-up) were identified. Multilevel mixed-effect models and multivariable regression were used to visualize pain courses and identify associated factors. Seventy-five patients who underwent primary TMR were included (median follow-up: 2.0 years), of whom 57.3% achieved sustained pain prophylaxis whereas 26.7% reported pain disappearance. Distal amputation levels (p = 0.036), a lower Elixhauser Comorbidity Index (p = 0.001), and the absence of psychiatric comorbidities (p = 0.039) were associated with pain prophylaxis. This study demonstrates that more than half of all patients undergoing primary TMR achieved sustained pain prophylaxis, and approximately a quarter of patients achieved sustained pain disappearance. Several factors associated with these favorable outcomes are described. These results will aid in preoperative counseling, managing patient expectations, and selecting patients who may benefit most from primary TMR surgery. IV – Therapeutic [ABSTRACT FROM AUTHOR]
Published: 2024
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25. The AAHKS Clinical Research Award: Extended Postoperative Oral Tranexamic Acid in Total Knee Arthroplasty: A Randomized Controlled Pilot Study.

Author: Kirwan, Mateo J., Diltz, Zachary R., Dixon, Derek T., Rivera-Peraza, Carlos A., Gammage, Christal J., Mihalko, Willliam M., Harkess, James W., Guyton, James L., Crockarell, John R., and Ford, Marcus C.
Abstract: Perioperative tranexamic acid (TXA) use with total knee arthroplasty (TKA) is widely accepted today. Recently, a few international groups have published on the safety and outcomes of extending TXA use in the postoperative period. Through a double-blinded, randomized control trial (RCT), we aimed to investigate the safety and clinical efficacy of extended postoperative oral TXA use in TKA performed in an American, free-standing ambulatory surgery center (ASC). Based on a power analysis, 40 patients undergoing primary TKA were randomized into 2 groups: extended oral TXA versus placebo. Both groups received a standard 1g intravenous TXA dose prior to incision and at the time of closure. The extended TXA group received an additional 1.95 g oral TXA dose following ambulation the day of surgery, plus on postoperative days 1,2, and 3. Patients who had a history of venous thromboembolism (VTE) or cancer were excluded. All patients received 81 mg of aspirin twice daily for VTE prophylaxis. Patients were followed on postoperative day 3 and weeks 2 and 6. Paired t -tests determined statistical significance. Extended TXA patients showed significantly increased knee flexion at 6 weeks (116.05 versus 106.5, P =.0308), improved VAS at 2 (2.5 versus 3.85, P =.039) and 6 weeks (1.35 versus 2.8, P =.011), and superior KOOS JR at 2 (66.87 versus 60.63, P =.03) and 6 weeks (73.33 versus 62.47, P =.0019) compared to placebo patients. No significant differences were found for changes in hemoglobin levels at any time points. No significant differences were found at 12 weeks for any clinical endpoints. No adverse events were noted in either cohort. When compared to placebo, the extended use of oral TXA in the postoperative period may safely result in improved motion, pain, and functional scores. Further investigation into 1-to-2-year outcomes, as well as the duration and dose of postoperative TXA use is warranted. [ABSTRACT FROM AUTHOR]
Published: 2024
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26. Miscoding in the Nationwide Inpatient Sample Database Raises Questions About Validity for Arthroplasty Research.

Author: Adalbert, Jenna R., Constantinescu, David S., Orton, Kevin S., and D'Apuzzo, Michele R.
Abstract: The use of administrative databases in arthroplasty research has increased over the past decade. The Nationwide Inpatient Sample (NIS) is one of the first and most frequently used. Despite many published articles using this dataset, there exists no standardization resource accounting for the potential of biased results. The purpose of our study was to assess the amount of discordant data between clinically relevant variables and propose a standard for using this database in primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). An initial set of patients undergoing total joint arthroplasty were identified from the NIS between 2016 and 2019 using the International Classification of Diseases, 10th Revision, Procedure Coding System. All records with THA and TKA in any of the procedure variables (PR1-PR20) were included. A total of 63 relevant and consistent variables were selected for individual comparison including diagnosis-related group (1), elective (1), procedure codes (20), day of main procedure (1), and diagnosis codes (40). Descriptive statistics were used. A total of 3,562,819 patients were included in the initial set. Using diagnosis-related groups, 5.3% were revision surgeries, 4.7% were not elective, 2.3% did not have THA or TKA as their primary procedure for hospitalization, and 2.9% of THA and 9.7% of TKA were bilateral. A total of 6.2% of the surgeries were done day(s) before or after admission, and 10.8% of THA and 6.3% of TKA were missing an orthopedic diagnosis for admission. Many had multiple orthopedic diagnoses for admission, 3.2% of THA and 0.7% of TKA. Overall miscoding was 23.3%. Using the NIS without standardized data processing to study elective, unilateral, primary THA and TKA introduces major bias. A logical and stepwise approach to curate the data before analysis is proposed to improve research quality when using this database in hip and knee arthroplasty studies. [ABSTRACT FROM AUTHOR]
Published: 2024
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27. Placental somatic mutation in human stillbirth and live birth: A pilot case-control study of paired placental, fetal, and maternal whole genomes.

Author: Wallace, Amelia D., Blue, Nathan R., Morgan, Terry, Workalemahu, Tsegaselassie, Silver, Robert M., and Quinlan, Aaron R.
Abstract: A high frequency of single nucleotide somatic mutations in the placenta has been recently described, but its relationship to placental dysfunction is unknown. We performed a pilot case-control study using paired fetal, maternal, and placental samples collected from healthy live birth controls (n = 10), live births with fetal growth restriction (FGR) due to placental insufficiency (n = 7), and stillbirths with FGR and placental insufficiency (n = 11). We quantified single nucleotide and structural somatic variants using bulk whole genome sequencing (30-60X coverage) in four biopsies from each placenta. We also assessed their association with clinical and histological evidence of placental dysfunction. Seventeen pregnancies had sufficiently high-quality placental, fetal, and maternal DNA for analysis. Each placenta had a median of 473 variants (range 111–870), with 95 % arising in just one biopsy within each placenta. In controls, live births with FGR, and stillbirths, the median variant counts per placenta were 514 (IQR 381–779), 582 (450–735), and 338 (245–441), respectively. After adjusting for depth of sequencing coverage and gestational age at birth, the somatic mutation burden was similar between groups (FGR live births vs. controls, adjusted diff. 59, 95 % CI -218 to +336; stillbirths vs controls, adjusted diff. −34, −351 to +419), and with no association with placental dysfunction (p = 0.7). We confirmed the high prevalence of somatic mutation in the human placenta and conclude that the placenta is highly clonal. We were not able to identify any relationship between somatic mutation burden and clinical or histologic placental insufficiency. • Somatic mutation is highly prevalent in the human placenta. • 95 % of comatic variants were present in just one of four biopsies in each placenta. • Somatic mutation estimates were driven by sequencing depth and gestational age. • Two variant calling algorithms yield very different somatic variation estimates. • We found no association between somatic variant burden and clinical outcome. [ABSTRACT FROM AUTHOR]
Published: 2024
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28. Surgical Approach Does Not Influence Instability Risk in Revision Total Hip Arthroplasty.

Author: Secrist, Eric S., Boutelle, Kelly, Pekas, Devon R., Neal, David C., Adrados, Murillo, Moskal, Joseph T., and Coobs, Benjamin R.
Abstract: Although the direct anterior (DA) approach has increased in popularity for primary total hip arthroplasty (THA), there is limited evidence regarding its use for revision THA. It is unknown whether the dislocation benefit seen in the primary setting translates to revision cases. This retrospective review compared the dislocation rates of revision THA performed through DA versus postero-lateral (PL) approaches at a single institution (2011 to 2021). Exclusion criteria included revision for instability, ≥ 2 prior revisions, approaches other than DA or PL, and placement of dual-mobility or constrained liners. There were 182 hips in 173 patients that met the inclusion criteria. The average follow-up was 6.5 years (range, 2 to 8 years). There was a trend toward more both-component revisions being performed through the PL approach. There were no differences in dislocation rates between the DA revision and PL revision cohorts, which were 8.1% (5 of 72) and 7.5% (9 of 120), respectively (P =.999). Dislocation trended lower when the revision approach was discordant from the primary approach compared to cases where primary and revision had a concordant approach (4.9 versus 8.5%), but this was not statistically significant (P =.740). No significant differences were found in return to operating room, 90-day emergency department visits, or 90-day readmissions. However, the length of stay was significantly shorter in patients who had DA revisions after a primary PL procedure (P =.021). Dislocation rates following revision THA did not differ between the DA and PL approaches irrespective of the primary approach. Surgeons should choose their revision approach based on their experience and the specific needs of the patient. [ABSTRACT FROM AUTHOR]
Published: 2024
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29. A Consecutive Series of Vancouver B2 Periprosthetic Femur Fractures Treated With Contemporary Monoblock Versus Modular Revision Stems: Clinical and Radiographic Outcomes.

Author: Siljander, Breana R., Chandi, Sonia K., Coxe, Francesca R., Nguyen, Joseph T., Sculco, Peter K., Chalmers, Brian P., Bostrom, Mathias P., and Gausden, Elizabeth B.
Abstract: Tapered fluted titanium (TFT) stems are the implant design of choice for managing Vancouver B2 periprosthetic femur fractures (PFFs), producing reliable results over the past few decades. The aim of this study was to compare the radiographic and clinical outcomes of Vancouver B2 PFFs treated with contemporary monoblock versus modular TFTs. A consecutive series of 113 patients (72 women, 64%, mean age 70 years [range, 26 to 96]) who had a B2 PFF were treated with either a monoblock (n = 42) or modular (n = 71) TFT stem between 2008 and 2021. The mean body mass index was 30 ± 7. The mean follow-up was 2.9 years. A radiographic review was performed to assess leg length and offset restoration, endosteal cortical contact length, and stem subsidence. Kaplan-Meier analyses were used to determine survivorship without revision, reoperation, or dislocation. There was no difference in the restoration of leg length (0.3 ± 8.0 mm) or offset (2.8 ± 8.2 mm) between the monoblock and modular cohorts (P >.05). Mean endosteal cortical contact length (47.2 ± 26.6 versus 46.7 ± 2 6.4 mm, P =.89) and stem subsidence (2.7 ± 3.5 versus 2.4 ± 3.2 mm, P =.66) did not differ. No difference in patient-reported outcome measures (Hip Disability and Osteoarthritis Outcome Score-Joint Replacement; Veterans RAND 12 Item Health Survey Physical and Mental; visual analog score; and Lower Extremity Activity Scale) between the groups was observed. Survivorship at 2 years free from reoperation, revision, and dislocation was 90.4, 90.3, and 97.6%, respectively, for the monoblock cohort; and 84.0, 86.9, and 90.0%, respectively, for the modular cohort. No significant differences in radiographic or clinical outcomes were observed between patients treated with monoblock or modular TFTs in this large series of B2 PFFs. [ABSTRACT FROM AUTHOR]
Published: 2024
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30. The CCJR® Charles A. Engh, Sr, MD. Excellence in Hip Research Award: The Evolution of Revision Hip Arthroplasty and Impact on the Trainee's Experience.

Author: Muscatelli, Stefano R., Strait, Alexander V., Ho, Henry, Dunn, John R., Hopper, Robert H., Fricka, Kevin B., and Hamilton, William G.
Abstract: Advances in total hip arthroplasty (THA) have resulted in evolving revision indications and intraoperative techniques, which can influence the exposure of trainees to complex cases. We report 3 decades of revision experience from a tertiary referral center that trains fellows, comparing the reasons for revision and the complexity of revisions over time. We retrospectively reviewed all revision THAs performed at our institution from 1990 to 2022. Revision diagnoses, components revised, types of revision implants used, and exposure techniques were collected. A "complex" revision was defined as a case that involved an extended trochanteric osteotomy, triflange and cup-cage construct, or acetabular augment. A total of 3,556 THA revisions were identified (108 revisions/year). Aseptic loosening was the most common indication in 1990 to 1999 (45 per year), but decreased to 28.3/year in 2010 to 2019. From 1990 to 1999 and 2010 to 2019, fracture increased from 3.1 to 7.3 per year, infection from 2.9/year to 16.9/year, and metallosis from 0.1 to 13.2 per year. Both component revision were common from 1990 to 1994 (42.6 per year), while polyethylene exchange was most common in 2010 to 2019 (43.3 per year). A decrease was observed in "complex" cases over time: 14.8 extended trochanteric osteotomies/year in 2000 to 2004 compared to 5.4 per year in 2018 to 2022, 4.5 triflange and cup-cage constructs/year in 2004 to 2007 compared to 0.8 per year in 2018 to 2022, and 4 acetabular augments per year in 2009 to 2012 compared to 1 per year in 2018 to 2022. Indications for revision have changed over the decades, while the number of "complex" revisions has gradually decreased, presumably due to advances in implants and materials. If this trend extends to other training institutions, the next generation of arthroplasty surgeons will have less exposure to complex revisions during their training. [ABSTRACT FROM AUTHOR]
Published: 2024
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31. Durability of Primary Total Hip Arthroplasty With Cementless Stems Without a Collar in Elderly Patients Age 75 Years and Over.

Author: Saldivar, Robert M., Buller, Leonard T., Deckard, Evan R., Sonn, Kevin A., and Meneghini, R. Michael
Abstract: Cementless femoral fixation in total hip arthroplasty (THA) has increased in prevalence worldwide. However, cementless fixation in elderly patients is controversial due to the risks of periprosthetic fracture and aseptic loosening. This study evaluated outcomes in patients undergoing primary THA utilizing a cementless stem without a collar, comparing those less than 75 years to those older than 75 years. Between 2011 and 2021, there were 2,605 cementless THAs performed by 4 surgeons utilizing a highly porous metal fixation surface without a collar and consistent clinical protocols. There were 469 patients who had an age ≥ 75 years. Revision rates, intraoperative fractures, and 90-day mortality were compared between cohorts. In the ≥ 75 year age group, there were more women, more American Society of Anesthesiologists physical status classification III or IV, a lower body mass index, and more kidney disease, osteoporosis, and thyroid disease (P ≤.002). All-cause revision rates trended lower for the ≥75 year age group compared to < 75 year (1.9 versus 3.5%, P =.082) at 20-months of follow-up. Moreover, there was no difference in all-cause femoral component revisions comparing ≥ 75 to < 75 year age groups (1.5 versus 2.2%, P =.375), with only 3 of 10 femoral revisions due to aseptic loosening being in the ≥ 75 year age group. Intraoperative fracture (0.2 versus 0.5%, P =.701) and 90-day mortality (0.2 versus 0.1%, P =.460) did not differ between ≥ 75 and < 75 year age groups. Older patients had comparable revision rates compared to younger patients using cementless femoral fixation without a collar. Furthermore, there was no difference in 90-day mortality or intraoperative fracture rates. Study findings provide evidence for the safety and durability of cementless THA using collarless femoral stems in elderly patients ≥ 75 years of age. III. [ABSTRACT FROM AUTHOR]
Published: 2024
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32. Gadolinium-doped injectable magnesium-calcium phosphate bone cements for noninvasive visualization.

Author: Krokhicheva, Polina A., Goldberg, Margarita A., Fomin, Alexander S., Khayrutdinova, Dinara R., Antonova, Olga S., Sadovnikova, Margarita A., Mikheev, Ivan V., Leonov, Aleksander V., Merzlyak, Ekaterina M., Kovalishina, Daria A., Akhmedova, Suraya A., Sergeeva, Natalia S., Gafurov, Marat R., Barinov, Sergey M., and Komlev, Vladimir S.
Abstract: • Magnesium calcium phosphate cements were doped with gadolinium ions. • The incorporation of Gd3+ into stanfieldite was confirmed by EPR. • Injectability reached 80%, and high cohesion was observed. • Cytocompatibility with MG-63 cells and antibacterial properties against E. coli were achieved. • Gd3+ improved contrast of microCT and MRI noninvasive visualization. Injectable bone cements are used in minimally invasive surgical techniques including vertebroplasty and kyphoplasty. This work is devoted to the development of magnesium-calcium phosphate cements (MCPCs) doped with gadolinium ions (Gd3+) for bone defect repair. Interaction between cement powders and a cement liquid resulted in the formation of newberyite and brushite phases, which gave mechanical strength up to 17 MPa without a thermal effect. The introduction of Gd3+ into the lattice was confirmed by electron paramagnetic resonance spectroscopy; the doping increased injectivity while giving rise to antibacterial properties against Escherichia coli. Assays of the cement samples soaking in Kokubo's simulated body fluid revealed the formation of calcium phosphate coatings on the cements' surface. The cements manifested biocompatibility with the MG-63 cell line and significantly enhanced contrast when Gd-MCPC was placed into a bone defect and examined by X-ray micro–computed tomography. For the first time, visualization of a Gd-doped cement material was achieved in a model of a bone defect analyzed by MRI. [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2024
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33. Systemic therapies for salivary gland cancer: Adenoid cystic carcinoma. REFCOR recommendations by the formal consensus method.

Author: Ferrand, F.-R., Even, C., Chabrillac, E., Thariat, J., Fakhry, N., Vergez, S., Bensadoun, R.-J., Sarradin, V., and Digue, L.
Subjects: SALIVARY gland cancer, LITERATURE reviews, THERAPEUTICS, HEAD tumors, NECK tumors, ADENOID cystic carcinoma
Abstract: To determine the therapeutic indications for systemic medical treatment in the management of adenoid cystic carcinoma (ACC) according to the clinical situation. The French Network of Rare Head and Neck Tumors (REFCOR) formed a steering group, which drafted a narrative review of the literature published on Medline and proposed recommendations. The level of adherence to the recommendations was then assessed by a rating group, according to the formal consensus method. ACCs are rare tumors and there is currently insufficient evidence to indicate chemotherapy at the localized stage. At the metastatic stage, progression is often slow. In case of oligometastatic ACC, local treatment should be discussed. The most often indolent nature of polymetastatic ACC can allow management by active surveillance. Molecular screening is recommended, for abnormalities potentially accessible to targeted therapy. ACCs are rare tumors for which there are currently few effective medical treatments. It is therefore recommended to include patients in clinical trials. [ABSTRACT FROM AUTHOR]
Published: 2024
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34. Systemic therapies for salivary gland carcinoma (excluding adenoid cystic carcinoma): REFCOR recommendations by the formal consensus method.

Author: Sarradin, V., Digue, L., Vergez, S., Thariat, J., Fakhry, N., Chabrillac, E., Bensadoun, R.-J., Ferrand, F.-R., and Even, C.
Subjects: SALIVARY gland cancer, LITERATURE reviews, SALIVARY glands, ANDROGEN receptors, MOLECULAR biology, ADENOID cystic carcinoma
Abstract: To determine the therapeutic indications for systemic medical treatment in the management of salivary gland carcinoma (excluding adenoid cystic carcinoma) according to the clinical situation. The French Network of Rare Head and Neck Tumors (REFCOR) formed a steering group who drafted a narrative review of the literature published on Medline and proposed recommendations. The level of adherence to the recommendations was then assessed by a rating group, according to the formal consensus method. Salivary gland carcinoma is rare and there is currently insufficient evidence to indicate chemotherapy at the localized stage. At the metastatic stage, initial management can be based on a phase of monitoring for indolent disease. Some histological subtypes (salivary duct carcinoma and adenocarcinoma) are more aggressive and require systemic treatment from the outset. To guide systemic treatment, it is recommended to perform immunohistochemistry and molecular biology analyses (overexpression of HER2 and androgen receptors, NTRK fusion, next-generation sequencing). Salivary gland carcinoma is a rare tumor for which there are currently few effective medical treatments. It is therefore recommended to include patients in clinical trials. [ABSTRACT FROM AUTHOR]
Published: 2024
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35. Ultra-high-resolution CT vs. invasive angiography for detecting hemodynamically significant coronary artery disease: Rationale and methods of the CORE-PRECISION multicenter study.

Author: Scarpa Matuck, Bruna R., Akino, Naruomi, Bakhshi, Hooman, Cox, Christopher, Ebrahimihoor, Elnaz, Ishida, Masaru, Lemos, Pedro A., Lima, Joao A.C., Matheson, Matthew B., Orii, Makoto, Ostovaneh, Aysa, Ostovaneh, Mohammad R., Schuijf, Joanne D., Szarf, Gilberto, Trost, Jeffrey C., Yoshioka, Kunihiro, and Arbab-Zadeh, Armin
Published: 2024
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36. Risk factors and clinical impact of multidrug resistance in healthcare-associated bacteraemic urinary tract infections: a post-hoc analysis of a multicentre prospective cohort in Spain.

Author: Gómez-Zorrilla, S., Becerra-Aparicio, F., Sendra, E., Zamorano, L., Grau, I., Pintado, V., Padilla, B., Benito, N., Boix-Palop, L., Fariñas, M.C., Peñaranda, M., Gamallo, M.R., Martinez, J.A., Morte-Romea, E., Del Pozo, J.L., López Montesinos, I., Durán-Jordà, X., Ponz, R., Cotarelo, M., and Cantón, R.
Abstract: The global burden associated with antimicrobial resistance is of increasing concern. To evaluate risk factors associated with multidrug-resistant (MDR) infection and its clinical impact in a cohort of patients with healthcare-associated bacteraemic urinary tract infections (BUTIs). This was a prospective, multicentre, post-hoc analysis of patients with healthcare-associated-BUTI (ITUBRAS-2). The primary outcome was MDR profile. Secondary outcomes were clinical response (at 48–72 h and at hospital discharge) and length of hospital stay from onset of BUTI. Logistic regression was used to evaluate variables associated with MDR profile and clinical response. Length of hospital stay was evaluated using multivariate median regression. In all, 443 episodes were included, of which 271 (61.17%) were classified as expressing an MDR profile. In univariate analysis, MDR profile was associated with E. coli episodes (odds ratio (OR): 3.13; 95% confidence interval (CI): 2.11–4.69, P < 0.001) and the extensively drug-resistant (XDR) pattern with P. aeruginosa aetiology (7.84; 2.37–25.95; P = 0.001). MDR was independently associated with prior use of fluoroquinolones (adjusted OR: 2.43; 95% CI: 1.25–4.69), cephalosporins (2.14; 1.35–3.41), and imipenem or meropenem (2.08; 1.03–4.20) but not with prior ertapenem. In terms of outcomes, MDR profile was not associated with lower frequency of clinical cure, but was associated with longer hospital stay. MDR profile was independently associated with prior use of fluoroquinolones, cephalosporins, imipenem, and meropenem, but not with prior ertapenem. MDR-BUTI episodes were not associated with worse clinical cure, although they were independently associated with longer duration of hospital stay. [ABSTRACT FROM AUTHOR]
Published: 2024
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37. Cementless Total Hip Arthroplasty With Paavilainen Femoral Shortening Osteotomy Can Provide Good Results at 10 Years in Patients Who Have Crowe IV Developmental Dysplasia of the Hip.

Author: Tikhilov, Rashid M., Dzhavadov, Alisagib A., Ziganshin, Dinis R., Zakhmatov, Nikita S., Alekberov, Rauf R., and Shubnyakov, Igor I.
Abstract: The aim of this study was to present the clinical and radiologic results of primary total hip arthroplasty (THA) using the femoral shortening osteotomy technique described by Paavilainen in patients who have Crowe IV developmental dysplasia of the hip. We retrospectively analyzed the results of primary THA using the Paavilainen technique in 335 hips. The mean follow-up was 10.2 years. The degree of limp, leg-length discrepancy, and patient satisfaction were assessed. The Oxford Hip Score was used to examine functional outcomes. A number of radiographic parameters were also assessed. The most common reason for revision surgery was nonunion of the distally advanced greater trochanter. This complication was observed in 22 hips (6.5%). The 10-year survival for acetabular components, it was 97.3%, and for femoral components was 98.7% with aseptic loosening as the end point, and 85.9% with reoperation for any reason as the end point. Patients demonstrated improved functional outcomes. The mean limb lengthening was 27.8 mm. Nonunion was more common if the contact length of the proximal femoral fragment with the lateral surface of the distal femoral fragment was less than 35 mm. Cementless primary THA using the femoral shortening osteotomy technique described by Paavilainen in patients who have Crowe IV dysplasia of the hip demonstrates good clinical and radiologic postoperative results. If the contact between the fragments after osteotomy is less than 35 mm, there is a high risk of nonunion, and supplemental fixation may be warranted. [ABSTRACT FROM AUTHOR]
Published: 2024
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38. Comparison of Delphi Consensus Criteria and Musculoskeletal Infection Society Outcome Reporting Tool Definitions of Successful Surgical Treatment of Periprosthetic Knee Infection.

Author: Zielinski, Matthew R., Ziemba-Davis, Mary, and Meneghini, R. Michael
Abstract: Agreement on success following surgical treatment for periprosthetic joint infection (PJI) is important for comparing the efficacy of different surgical approaches with varying consequences and outcomes and setting patient expectations. We compared success rates following two-stage exchange arthroplasty for knee PJI using two expert-consensus definitions of success. Prospectively documented data for 57 knees treated by a single surgeon at an academic tertiary care center were retrospectively reviewed. Treatment outcomes were quantified using the Delphi Consensus Criteria and the Musculoskeletal Infection Society Outcome Reporting Tool (MSIS ORT). Success rates were 81% using the Delphi Consensus Criteria and 56% using the MSIS ORT (P =.008). The MSIS ORT success rates increased to 76% when aseptic revisions and deaths unrelated to PJI were not penalized as failures of treatment. Predicted probabilities of successful treatment in a hypothetical case scenario were lowest based on the MSIS ORT and similarly higher using Delphi Consensus Criteria and MSIS ORT modified for both women (53.0, 90.8, and 88.7%) and men (29.1, 89.1, and 89.3%). Study observations underscore the need for a uniformly accepted single definition of surgical treatment success. [ABSTRACT FROM AUTHOR]
Published: 2024
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39. Current epidemiology of tinea corporis and tinea cruris causative species: Analysis of data from a major commercial laboratory, United States.

Author: Zarzeka, Daria, Benedict, Kaitlin, McCloskey, Maryann, Lockhart, Shawn R., Lipner, Shari R., and Gold, Jeremy A.W.
Published: 2024
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40. Asthma control in the United States: Relationships between short-acting β2-agonist and systemic corticosteroid use.

Author: Chupp, Geoffrey, Murphy, Kevin R., Gandhi, Hitesh N., Gilbert, Ileen, and Bleecker, Eugene R.
Published: 2024
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41. One-year Results of Minimally Invasive Sutured Fixation of the Slipped Ribs in the Pediatric Population.

Author: Polycarpou, Andreas, Chopko, Trevor C., Glasgow, Amy E., McCarthy, Sarah R., Hilliker, Daniel R., Wilder, Robert T., and Klinkner, Denise B.
Abstract: Costal cartilage resection with or without rib resection is the gold standard surgery for slipping rib syndrome. Minimally invasive restoration of normal anatomy via nonabsorbable sutures has been described in the adult population with encouraging results. We sought to assess the efficacy of minimally invasive sutured fixation of the hypermobile rib in the pediatric population. A retrospective review was performed at Mayo Clinic involving 31 pediatric patients diagnosed with slipped rib syndrome. Minimally invasive sutured open reduction internal fixation was performed between 2020 and 2022. The standardized Örebro Musculoskeletal Pain Screening Questionnaire was given at dedicated time points pre- and post-operatively to assess efficacy. Significance was determined via the Wilcoxon rank sum test. SRS was diagnosed clinically in 31 patients (24 females, 7 males, 1220 years-old). Symptoms were present for an average of 18.9 months and patients had seen an average of 4.7 specialists. Traumatic causes were identified in three patients and eight patients had hypermobility. At one month follow up, there were no surgical complications and patients reported significantly less pain (p < 0.001). Preoperative analgesics reduced by 80%. Ultimately, seven patients underwent a second operation; three patients underwent a third operation; one patient underwent five total operations. Recurrent pain was reported in six patients. Only nine patients followed-up at 1-year post-operation. Pediatric patients with SRS demonstrated an early positive response to suture fixation without costal cartilage excision. Reoperation and recurrent pain, however, remain significant in this population. Level IV. Case series with no comparison group. • What is currently known about this topic? The gold standard treatment for slipped rib syndrome is costal cartilage resection with or without rib resection. Minimally invasive restoration of normal anatomy via nonabsorbable sutures has been described in the adult population with encouraging results. • What new information is contained in this article? Pediatric patients with SRS demonstrated an early positive response to suture fixation without costal cartilage excision. Reoperation and recurrent pain remained significant in our cohort, putting into question the durability and long-term efficacy of this repair. [ABSTRACT FROM AUTHOR]
Published: 2024
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42. Percutaneous left atrial appendage closure for stroke prevention in hypertrophic cardiomyopathy patients with atrial fibrillation.

Author: Aglan, Amro, Fath, Ayman R., Maron, Barry J., Maron, Martin S., Prasad, Anand, Almomani, Ahmed, Hammadah, Muhammad, Reynolds, Matthew R., and Rowin, Ethan J.
Abstract: Percutaneous left atrial appendage closure (LAAC) is an effective alternative strategy for stroke prevention in patients with atrial fibrillation (AF) at high risk for bleeding with anticoagulation (AC). Efficacy of this strategy in hypertrophic cardiomyopathy (HCM) remains uncertain. The study aimed to compare risk of stroke in HCM-AF patients treated with LAAC with those treated with AC. By use of the TriNetX Global Research Network, HCM-AF patients from 2015 to 2024 were assigned to categories of treatment with LAAC and treatment solely with AC and observed for 3 years for ischemic stroke, systemic embolism, and all-cause mortality. Propensity score matching was used to limit confounders. Of 14,867 HCM-AF patients identified, 364 (2.5%) were treated with LAAC vs 14,503 (97.5%) treated with AC. HCM LAAC patients were older (72 vs 67 years; P <.001) and had more comorbidities and more prior bleeding events, including higher rate of prior gastrointestinal bleeding (68% vs 18%; P <.001), compared with HCM patients treated solely with AC. After propensity score matching, there was no baseline difference between groups including prior bleeding events (P >.05). During follow-up, HCM patients treated with LAAC had higher rates of ischemic stroke (13% vs 8%; hazard ratio, 1.9; P =.006) and systemic embolism (14% vs 9%; hazard ratio, 1.8; P =.006) but no difference in mortality compared with matched HCM patients receiving AC. These real-world data do not support percutaneous LAAC in HCM-AF patients as the primary treatment strategy during long-term AC to reduce stroke risk. However, LAAC may remain a reasonable option for HCM-AF patients who are unable to tolerate AC because of prohibitive bleeding risk. [ABSTRACT FROM AUTHOR]
Published: 2024
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43. Clinical Assessment of the Autonomic Nervous System.

Author: Baker, Jacquie R., Hira, Rashmin, Uppal, Jaiden, and Raj, Satish R.
Abstract: This review explores standardized clinical assessments for evaluating autonomic nervous system function. Here, we emphasize components of the autonomic medical history as the first pivotal test of the autonomic assessment. We further focus on standard noninvasive cardiovascular autonomic tests including heart rate responses to deep breathing, Valsalva maneuvers, and orthostatic challenges, along with insights from neurochemical tests and quantitative sudomotor axon reflex testing. The article also covers practical aspects of cardiovascular autonomic monitoring, including patient set-up using beat-to-beat blood pressure and ECG, specific assessment protocols, and their respective clinical interpretations that provide insight into adrenergic, cardiovagal, and sudomotor function. [ABSTRACT FROM AUTHOR]
Published: 2024
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44. Wedge Resection Outcomes: A Comparison of Video-Assisted and Robot-Assisted Wedge Resections.

Author: Martin, Jonathan L., Mack, Shale J., Rshaidat, Hamza, Collins, Micaela L., Whitehorn, Gregory L., Grenda, Tyler R., Evans III, Nathaniel R., and Okusanya, Olugbenga T.
Abstract: Quality of oncologic resection for early-stage non-small cell lung cancer (NSCLC) may differ by surgical approach. Minimally invasive surgery has become the standard for surgical treatment of NSCLC. Our study compares quality of wedge resection by video-assisted thoracoscopic surgery (VATS) vs robotic video-assisted thoracoscopic surgery (RVATS). We hypothesized that RVATS would result in higher quality resections and improved patient outcomes. A retrospective cohort analysis was completed using the National Cancer Database for patients with clinical stage 1 NSCLC with tumor size ≤2 cm who underwent a minimally invasive surgery wedge resection from 2010 to 2019. Wedge resections approached with RVATS were compared with VATS. A 1:1 propensity score matched analysis was performed. The cohort included 16,559 patients; 80.4% (13,406) received VATS and 18.9% (3153) received RVATS. Compared with RVATS, a VATS approach was associated with a lower likelihood of lymph nodes being examined (59.0% vs 75.2%; P <.001), fewer nodes dissected (median, 4 vs 5; P <.001), and less adjuvant systemic therapy administered (1.3% vs 2.2%; P <.001). Propensity score matching resulted in 2590 balanced pairs. Statistical significance was maintained for likelihood of lymph nodes examined, number of nodes dissected, and adjuvant systemic therapy administered. There was no significant difference in nodal upstaging after propensity score matching (3.7% vs 4.3%; P =.37). Compared with the VATS approach, wedge resections by RVATS for early-stage NSCLC were more likely to be associated with increased lymph nodes resected. These data may support increased use of RVATS for wedge resections. [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2024
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45. Measurements of azimuthal anisotropy of nonprompt D0 mesons in PbPb collisions at sNN=5.02TeV

Author: Tumasyan, A, Adam, W, Andrejkovic, J, Bergauer, T, Chatterjee, S, Damanakis, K, Dragicevic, M, Escalante Del Valle, A, Hussain, P, Jeitler, M, Krammer, N, Lechner, L, Liko, D, Mikulec, I, Paulitsch, P, Pitters, F, Schieck, J, Schofbeck, R, Schwarz, D, Sonawane, M, Templ, S, Waltenberger, W, Wulz, C, Darwish, M, Janssen, T, Kello, T, Rejeb Sfar, H, Van Mechelen, P, Bols, E, D'Hondt, J, De Moor, A, Delcourt, M, El Faham, H, Lowette, S, Moortgat, S, Morton, A, Muller, D, Sahasransu, A, Tavernier, S, Van Doninck, W, Vannerom, D, Clerbaux, B, De Lentdecker, G, Favart, L, Hohov, D, Jaramillo, J, Lee, K, Mahdavikhorrami, M, Makarenko, I, Malara, A, Paredes, S, Petre, L, Postiau, N, Thomas, L, Vanden Bemden, M, Vander Velde, C, Vanlaer, P, Dobur, D, Knolle, J, Lambrecht, L, Mestdach, G, Rendon, C, Samalan, A, Skovpen, K, Tytgat, M, Van Den Bossche, N, Vermassen, B, Wezenbeek, L, Benecke, A, Bruno, G, Bury, F, Caputo, C, David, P, Delaere, C, Donertas, I, Giammanco, A, Jaffel, K, Jain, S, Lemaitre, V, Mondal, K, Taliercio, A, Tran, T, Vischia, P, Wertz, S, Alves, G, Coelho, E, Hensel, C, Moraes, A, Rebello Teles, P, Alda Junior, W, Alves Gallo Pereira, M, Barroso Ferreira Filho, M, Brandao Malbouisson, H, Carvalho, W, Chinellato, J, Da Costa, E, Da Silveira, G, De Jesus Damiao, D, Dos Santos Sousa, V, Fonseca De Souza, S, Martins, J, Mora Herrera, C, Mota Amarilo, K, Mundim, L, Nogima, H, Santoro, A, Silva Do Amaral, S, Sznajder, A, Thiel, M, Torres Da Silva De Araujo, F, Vilela Pereira, A, Bernardes, C, Calligaris, L, Fernandez Perez Tomei, T, Gregores, E, Mercadante, P, Novaes, S, Padula, S, Aleksandrov, A, Antchev, G, Hadjiiska, R, Iaydjiev, P, Misheva, M, Rodozov, M, Shopova, M, Sultanov, G, Dimitrov, A, Ivanov, T, Litov, L, Pavlov, B, Petkov, P, Petrov, A, Shumka, E, Thakur, S, Cheng, T, Javaid, T, Mittal, M, Yuan, L, Ahmad, M, Bauer, G, Hu, Z, Lezki, S, Yi, K, Chen, G, Chen, H, Chen, M, Iemmi, F, Jiang, C, Kapoor, A, Liao, H, Liu, Z, Milosevic, V, Monti, F, Sharma, R, Tao, J, Thomas-Wilsker, J, Wang, J, Zhang, H, Zhao, J, Agapitos, A, An, Y, Ban, Y, Levin, A, Li, C, Li, Q, Lyu, X, Mao, Y, Qian, S, Sun, X, Wang, D, Xiao, J, Yang, H, Lu, M, You, Z, Lu, N, Gao, X, Leggat, D, Okawa, H, Zhang, Y, Lin, Z, Lu, C, Xiao, M, Avila, C, Barbosa Trujillo, D, Cabrera, A, Florez, C, Fraga, J, Mejia Guisao, J, Ramirez, F, Rodriguez, M, Ruiz Alvarez, J, Giljanovic, D, Godinovic, N, Lelas, D, Puljak, I, Antunovic, Z, Kovac, M, Sculac, T, Brigljevic, V, Chitroda, B, Ferencek, D, Mishra, S, Roguljic, M, Starodumov, A, Susa, T, Attikis, A, Christoforou, K, Kolosova, M, Konstantinou, S, Mousa, J, Nicolaou, C, Ptochos, F, Razis, P, Rykaczewski, H, Saka, H, Stepennov, A, Finger, M, Kveton, A, Ayala, E, Carrera Jarrin, E, Abdelalim, A, Salama, E, Abdullah Al-Mashad, M, Mahmoud, M, Bhowmik, S, Dewanjee, R, Ehataht, K, Kadastik, M, Lange, T, Nandan, S, Nielsen, C, Pata, J, Raidal, M, Tani, L, Veelken, C, Eerola, P, Kirschenmann, H, Osterberg, K, Voutilainen, M, Bharthuar, S, Brucken, E, Garcia, F, Havukainen, J, Kim, M, Kinnunen, R, Lampen, T, Lassila-Perini, K, Lehti, S, Linden, T, Lotti, M, Martikainen, L, Myllymaki, M, Ott, J, Rantanen, M, Siikonen, H, Tuominen, E, Tuominiemi, J, Luukka, P, Petrow, H, Tuuva, T, Amendola, C, Besancon, M, Couderc, F, Dejardin, M, Denegri, D, Faure, J, Ferri, F, Ganjour, S, Gras, P, Hamel de Monchenault, G, Lohezic, V, Malcles, J, Rander, J, Rosowsky, A, Sahin, M, Savoy-Navarro, A, Simkina, P, Titov, M, Baldenegro Barrera, C, Beaudette, F, Buchot Perraguin, A, Busson, P, Cappati, A, Charlot, C, Damas, F, Davignon, O, Diab, B, Falmagne, G, Fontana Santos Alves, B, Ghosh, S, Granier de Cassagnac, R, Hakimi, A, Harikrishnan, B, Liu, G, Motta, J, Nguyen, M, Ochando, C, Portales, L, Salerno, R, Sarkar, U, Sauvan, J, Sirois, Y, Tarabini, A, Vernazza, E, Zabi, A, Zghiche, A, Agram, J, Andrea, J, Apparu, D, Bloch, D, Bourgatte, G, Brom, J, Chabert, E, Collard, C, Darej, D, Goerlach, U, Grimault, C, Le Bihan, A, Van Hove, P, Beauceron, S, Blancon, B, Boudoul, G, Carle, A, Chanon, N, Choi, J, Contardo, D, Depasse, P, Dozen, C, El Mamouni, H, Fay, J, Gascon, S, Gouzevitch, M, Grenier, G, Ille, B, Laktineh, I, Lethuillier, M, Mirabito, L, Perries, S, Torterotot, L, Vander Donckt, M, Verdier, P, Viret, S, Lomidze, I, Toriashvili, T, Tsamalaidze, Z, Botta, V, Feld, L, Klein, K, Lipinski, M, Meuser, D, Pauls, A, Rowert, N, Teroerde, M, Diekmann, S, Dodonova, A, Eich, N, Eliseev, D, Erdmann, M, Fackeldey, P, Fasanella, D, Fischer, B, Hebbeker, T, Hoepfner, K, Ivone, F, Lee, M, Mastrolorenzo, L, Merschmeyer, M, Meyer, A, Mondal, S, Mukherjee, S, Noll, D, Novak, A, Nowotny, F, Pozdnyakov, A, Rath, Y, Redjeb, W, Reithler, H, Schmidt, A, Schuler, S, Sharma, A, Stein, A, Vigilante, L, Wiedenbeck, S, Zaleski, S, Dziwok, C, Flugge, G, Haj Ahmad, W, Hlushchenko, O, Kress, T, Nowack, A, Pooth, O, Stahl, A, Ziemons, T, Zotz, A, Aarup Petersen, H, Aldaya Martin, M, Asmuss, P, Baxter, S, Bayatmakou, M, Behnke, O, Bermudez Martinez, A, Bhattacharya, S, Bin Anuar, A, Blekman, F, Borras, K, Brunner, D, Campbell, A, Cardini, A, Cheng, C, Colombina, F, Consuegra Rodriguez, S, Correia Silva, G, De Silva, M, Didukh, L, Eckerlin, G, Eckstein, D, Estevez Banos, L, Filatov, O, Gallo, E, Geiser, A, Giraldi, A, Greau, G, Grohsjean, A, Guglielmi, V, Guthoff, M, Jafari, A, Jomhari, N, Kaech, B, Kasemann, M, Kaveh, H, Kleinwort, C, Kogler, R, Komm, M, Krucker, D, Lange, W, Leyva Pernia, D, Lipka, K, Lohmann, W, Mankel, R, Melzer-Pellmann, I, Mendizabal Morentin, M, Metwally, J, Milella, G, Mormile, M, Mussgiller, A, Nurnberg, A, Otarid, Y, Perez Adan, D, Raspereza, A, Ribeiro Lopes, B, Rubenach, J, Saggio, A, Saibel, A, Savitskyi, M, Scham, M, Scheurer, V, Schnake, S, Schutze, P, Schwanenberger, C, Shchedrolosiev, M, Sosa Ricardo, R, Stafford, D, Tonon, N, Van De Klundert, M, Vazzoler, F, Ventura Barroso, A, Walsh, R, Walter, D, Wang, Q, Wen, Y, Wichmann, K, Wiens, L, Wissing, C, Wuchterl, S, Yang, Y, Zimermmane Castro Santos, A, Albrecht, A, Albrecht, S, Antonello, M, Bein, S, Benato, L, Bonanomi, M, Connor, P, De Leo, K, Eich, M, El Morabit, K, Feindt, F, Frohlich, A, Garbers, C, Garutti, E, Hajheidari, M, Haller, J, Hinzmann, A, Jabusch, H, Kasieczka, G, Keicher, P, Klanner, R, Korcari, W, Kramer, T, Kutzner, V, Labe, F, Lange, J, Lobanov, A, Matthies, C, Mehta, A, Moureaux, L, Mrowietz, M, Nigamova, A, Nissan, Y, Paasch, A, Pena Rodriguez, K, Quadfasel, T, Rieger, M, Rieger, O, Savoiu, D, Schindler, J, Schleper, P, Schroder, M, Schwandt, J, Sommerhalder, M, Stadie, H, Steinbruck, G, Tews, A, Wolf, M, Brommer, S, Burkart, M, Butz, E, Caspart, R, Chwalek, T, Dierlamm, A, Droll, A, Faltermann, N, Giffels, M, Gosewisch, J, Gottmann, A, Hartmann, F, Horzela, M, Husemann, U, Klute, M, Koppenhofer, R, Link, M, Lintuluoto, A, Maier, S, Mitra, S, Muller, T, Neukum, M, Oh, M, Quast, G, Rabbertz, K, Rauser, J, Schnepf, M, Shvetsov, I, Simonis, H, Trevisani, N, Ulrich, R, van der Linden, J, Von Cube, R, Wassmer, M, Wieland, S, Wolf, R, Wozniewski, S, Wunsch, S, Zuo, X, Anagnostou, G, Assiouras, P, Daskalakis, G, Kyriakis, A, Stakia, A, Diamantopoulou, M, Karasavvas, D, Kontaxakis, P, Manousakis-Katsikakis, A, Panagiotou, A, Papavergou, I, Saoulidou, N, Theofilatos, K, Tziaferi, E, Vellidis, K, Zisopoulos, I, Bakas, G, Chatzistavrou, T, Kousouris, K, Papakrivopoulos, I, Tsipolitis, G, Zacharopoulou, A, Adamidis, K, Bestintzanos, I, Evangelou, I, Foudas, C, Gianneios, P, Kamtsikis, C, Katsoulis, P, Kokkas, P, Kosmoglou Kioseoglou, P, Manthos, N, Papadopoulos, I, Strologas, J, Csanad, M, Farkas, K, Gadallah, M, Lokos, S, Major, P, Mandal, K, Pasztor, G, Radl, A, Suranyi, O, Veres, G, Bartok, M, Bencze, G, Hajdu, C, Horvath, D, Sikler, F, Veszpremi, V, Beni, N, Czellar, S, Karancsi, J, Molnar, J, Szillasi, Z, Teyssier, D, Raics, P, Ujvari, B, Csorgo, T, Nemes, F, Novak, T, Babbar, J, Bansal, S, Beri, S, Bhatnagar, V, Chaudhary, G, Chauhan, S, Dhingra, N, Gupta, R, Kaur, A, Kaur, H, Kaur, M, Kumar, S, Kumari, P, Meena, M, Sandeep, K, Sheokand, T, Singh, J, Singla, A, Virdi, A, Ahmed, A, Bhardwaj, A, Chhetri, A, Choudhary, B, Kumar, A, Naimuddin, M, Ranjan, K, Saumya, S, Baradia, S, Barman, S, Bhowmik, D, Dutta, S, Gomber, B, Maity, M, Palit, P, Saha, G, Sahu, B, Sarkar, S, Behera, P, Behera, S, Kalbhor, P, Komaragiri, J, Kumar, D, Muhammad, A, Panwar, L, Pradhan, R, Pujahari, P, Sikdar, A, Tiwari, P, Verma, S, Naskar, K, Aziz, T, Das, I, Dugad, S, Kumar, M, Mohanty, G, Suryadevara, P, Banerjee, S, Chudasama, R, Guchait, M, Karmakar, S, Majumder, G, Mazumdar, K, Thachayath, A, Bahinipati, S, Das, A, Kar, C, Mal, P, Mishra, T, Muraleedharan Nair Bindhu, V, Nayak, A, Saha, P, Swain, S, Vats, D, Alpana, A, Dube, S, Kansal, B, Laha, A, Pandey, S, Rastogi, A, Sharma, S, Bakhshiansohi, H, Khazaie, E, Zeinali, M, Chenarani, S, Etesami, S, Khakzad, M, Mohammadi Najafabadi, M, Grunewald, M, Abbrescia, M, Aly, R, Aruta, C, Colaleo, A, Creanza, D, De Filippis, N, De Palma, M, Di Florio, A, Elmetenawee, W, Errico, F, Fiore, L, Iaselli, G, Maggi, G, Maggi, M, Margjeka, I, Mastrapasqua, V, My, S, Nuzzo, S, Pellecchia, A, Pompili, A, Pugliese, G, Radogna, R, Ramos, D, Ranieri, A, Selvaggi, G, Silvestris, L, Simone, F, Sozbilir, U, Stamerra, A, Venditti, R, Verwilligen, P, Abbiendi, G, Battilana, C, Bonacorsi, D, Borgonovi, L, Campanini, R, Capiluppi, P, Castro, A, Cavallo, F, Ciocca, C, Cuffiani, M, Dallavalle, G, Diotalevi, T, Fabbri, F, Fanfani, A, Giacomelli, P, Giommi, L, Grandi, C, Guiducci, L, Lo Meo, S, Lunerti, L, Marcellini, S, Masetti, G, Navarria, F, Perrotta, A, Primavera, F, Rossi, A, Rovelli, T, Siroli, G, Costa, S, Di Mattia, A, Potenza, R, Tricomi, A, Tuve, C, Barbagli, G, Bardelli, G, Camaiani, B, Cassese, A, Ceccarelli, R, Ciulli, V, Civinini, C, D'Alessandro, R, Focardi, E, Latino, G, Lenzi, P, Lizzo, M, Meschini, M, Paoletti, S, Seidita, R, Sguazzoni, G, Viliani, L, Benussi, L, Bianco, S, Meola, S, Piccolo, D, Bozzo, M, Chatagnon, P, Ferro, F, Robutti, E, Tosi, S, Benaglia, A, Boldrini, G, Brivio, F, Cetorelli, F, De Guio, F, Dinardo, M, Dini, P, Gennai, S, Ghezzi, A, Govoni, P, Guzzi, L, Lucchini, M, Malberti, M, Malvezzi, S, Massironi, A, Menasce, D, Moroni, L, Paganoni, M, Pedrini, D, Pinolini, B, Ragazzi, S, Redaelli, N, Tabarelli de Fatis, T, Zuolo, D, Buontempo, S, Carnevali, F, Cavallo, N, De Iorio, A, Fabozzi, F, Iorio, A, Lista, L, Paolucci, P, Rossi, B, Sciacca, C, Azzi, P, Bacchetta, N, Benettoni, M, Bisello, D, Bortignon, P, Bragagnolo, A, Carlin, R, Checchia, P, Dorigo, T, Gasparini, F, Gasparini, U, Grosso, G, Layer, L, Lusiani, E, Margoni, M, Meneguzzo, A, Pazzini, J, Ronchese, P, Simonetto, F, Strong, G, Tosi, M, Yarar, H, Zanetti, M, Zotto, P, Zucchetta, A, Zumerle, G, Abu Zeid, S, Aime, C, Braghieri, A, Calzaferri, S, Fiorina, D, Montagna, P, Re, V, Riccardi, C, Salvini, P, Vai, I, Vitulo, P, Asenov, P, Bilei, G, Ciangottini, D, Fano, L, Magherini, M, Mantovani, G, Mariani, V, Menichelli, M, 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S., Zarubin A., Zhizhin I., and Zhokin A.
Abstract: Measurements of the elliptic (v2) and triangular (v3) azimuthal anisotropy coefficients are presented for [Formula presented] mesons produced in [Formula presented] hadron decays (nonprompt [Formula presented] mesons) in lead-lead collisions at sNN=5.02TeV. The results are compared with previously published charm meson anisotropies measured using prompt [Formula presented] mesons. The data were collected with the CMS detector in 2018 with an integrated luminosity of 0.58nb−1. Azimuthal anisotropy is sensitive to the interactions of quarks with the hot and dense medium created in heavy ion collisions. Comparing results for prompt and nonprompt [Formula presented] mesons can assist in understanding the mass dependence of these interactions. The nonprompt results show lower magnitudes of v2 and v3 and weaker dependences on the meson transverse momentum and collision centrality than those found for prompt [Formula presented] mesons. The results are in agreement with theoretical predictions that include a mass dependence in the interactions of quarks with the medium.
Published: 2024

46. Search for an exotic decay of the Higgs boson into a Z boson and a pseudoscalar particle in proton-proton collisions at s=13TeV

Author: Hayrapetyan, A, Tumasyan, A, Adam, W, Andrejkovic, J, Bergauer, T, Chatterjee, S, Damanakis, K, Dragicevic, M, Escalante Del Valle, A, Hussain, P, Jeitler, M, Krammer, N, Liko, D, Mikulec, I, Schieck, J, Schofbeck, R, Schwarz, D, Sonawane, M, Templ, S, Waltenberger, W, Wulz, C, Darwish, M, Janssen, T, Van Mechelen, P, Bols, E, D'Hondt, J, Dansana, S, De Moor, A, Delcourt, M, El Faham, H, Lowette, S, Makarenko, I, Muller, D, Sahasransu, A, Tavernier, S, Tytgat, M, Van Putte, S, Vannerom, D, Clerbaux, B, De Lentdecker, G, Favart, L, Hohov, D, Jaramillo, J, Khalilzadeh, A, Lee, K, Mahdavikhorrami, M, Malara, A, Paredes, S, Petre, L, Postiau, N, Thomas, L, Vanden Bemden, M, Vander Velde, C, Vanlaer, P, De Coen, M, Dobur, D, Hong, Y, Knolle, J, Lambrecht, L, Mestdach, G, Rendon, C, Samalan, A, Skovpen, K, Van Den Bossche, N, Wezenbeek, L, Benecke, A, Bruno, G, Caputo, C, Delaere, C, Donertas, I, Giammanco, A, Jaffel, K, Jain, S, Lemaitre, V, Lidrych, J, Mastrapasqua, P, Mondal, K, Tran, T, Wertz, S, Alves, G, Coelho, E, Hensel, C, Menezes De Oliveira, T, Moraes, A, Rebello Teles, P, Soeiro, M, Alda Junior, W, Alves Gallo Pereira, M, Barroso Ferreira Filho, M, Brandao Malbouisson, H, Carvalho, W, Chinellato, J, Da Costa, E, Da Silveira, G, De Jesus Damiao, D, Fonseca De Souza, S, Martins, J, Mora Herrera, C, Mota Amarilo, K, Mundim, L, Nogima, H, Santoro, A, Silva Do Amaral, S, Sznajder, A, Thiel, M, Vilela Pereira, A, Bernardes, C, Calligaris, L, Fernandez Perez Tomei, T, Gregores, E, Mercadante, P, Novaes, S, Orzari, B, Padula, S, Aleksandrov, A, Antchev, G, Hadjiiska, R, Iaydjiev, P, Misheva, M, Shopova, M, Sultanov, G, Dimitrov, A, Ivanov, T, Litov, L, Pavlov, B, Petkov, P, Petrov, A, Shumka, E, Keshri, S, Thakur, S, Cheng, T, Guo, Q, Javaid, T, Mittal, M, Yuan, L, Bauer, G, Hu, Z, Yi, K, Chen, G, Chen, H, Chen, M, Iemmi, F, Jiang, C, Kapoor, A, Liao, H, Liu, Z, Monti, F, Sharma, R, Song, J, Tao, J, Wang, C, Wang, J, Wang, Z, Zhang, H, Agapitos, A, Ban, Y, 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C., Sharma A., Stein A., Torres Da Silva De Araujo F., Vigilante L., Wiedenbeck S., Zaleski S., Dziwok C., Flugge G., Haj Ahmad W., Kress T., Nowack A., Pooth O., Stahl A., Ziemons T., Zotz A., Aarup Petersen H., Aldaya Martin M., Alimena J., Amoroso S., An Y., Baxter S., Bayatmakou M., Becerril Gonzalez H., Behnke O., Belvedere A., Bhattacharya S., Blekman F., Borras K., Brunner D., Campbell A., Cardini A., Cheng C., Colombina F., Consuegra Rodriguez S., Correia Silva G., De Silva M., Eckerlin G., Eckstein D., Estevez Banos L. I., Filatov O., Gallo E., Geiser A., Giraldi A., Greau G., Guglielmi V., Guthoff M., Hinzmann A., Jafari A., Jeppe L., Jomhari N. Z., Kaech B., Kasemann M., Kaveh H., Kleinwort C., Kogler R., Komm M., Krucker D., Lange W., Leyva Pernia D., Lipka K., Lohmann W., Mankel R., Melzer-Pellmann I. -A., Mendizabal Morentin M., Metwally J., Meyer A. 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R., Ambrozas M., Juodagalvis A., Rinkevicius A., Tamulaitis G., Bin Norjoharuddeen N., Yusuff I., Zolkapli Z., Benitez J. F., Castaneda Hernandez A., Encinas Acosta H. A., Gallegos Marinez L. G., Leon Coello M., Murillo Quijada J. A., Sehrawat A., Valencia Palomo L., Ayala G., Castilla-Valdez H., De La Cruz-Burelo E., Heredia-De La Cruz I., Lopez-Fernandez R., Mondragon Herrera C. A., Sanchez Hernandez A., Oropeza Barrera C., Ramirez Garcia M., Bautista I., Pedraza I., Salazar Ibarguen H. A., Uribe Estrada C., Bubanja I., Raicevic N., Butler P. H., Ahmad A., Asghar M. I., Awais A., Awan M. I. M., Hoorani H. R., Khan W. A., Avati V., Grzanka L., Malawski M., Bialkowska H., Bluj M., Boimska B., Gorski M., Kazana M., Szleper M., Zalewski P., Bunkowski K., Doroba K., Kalinowski A., Konecki M., Krolikowski J., Muhammad A., Pozniak K., Zabolotny W., Araujo M., Bastos D., Beirao Da Cruz E Silva C., Boletti A., Bozzo M., Faccioli P., Gallinaro M., Hollar J., Leonardo N., Niknejad T., Petrilli A., Pisano M., Seixas J., Varela J., Adzic P., Milenovic P., Dordevic M., Milosevic J., Rekovic V., Aguilar-Benitez M., Alcaraz Maestre J., Barrio Luna M., Bedoya C. F., Cepeda M., Cerrada M., Colino N., De La Cruz B., Delgado Peris A., Fernandez Del Val D., Fernandez Ramos J. P., Flix J., Fouz M. C., Gonzalez Lopez O., Goy Lopez S., Hernandez J. M., Josa M. I., Leon Holgado J., Moran D., Morcillo Perez C. M., Navarro Tobar A., Perez Dengra C., Perez-Calero Yzquierdo A., Puerta Pelayo J., Redondo I., Redondo Ferrero D. D., Romero L., Sanchez Navas S., Urda Gomez L., Vazquez Escobar J., Willmott C., de Troconiz J. F., Alvarez Gonzalez B., Cuevas J., Fernandez Menendez J., Folgueras S., Gonzalez Caballero I., Gonzalez Fernandez J. R., Palencia Cortezon E., Ramon Alvarez C., Rodriguez Bouza V., Soto Rodriguez A., Trapote A., Vico Villalba C., Vischia P., Bhowmik S., Blanco Fernandez S., Brochero Cifuentes J. A., Cabrillo I. J., Calderon A., Duarte Campderros J., Fernandez M., Fernandez Madrazo C., Gomez G., Lasaosa Garcia C., Martinez Rivero C., Martinez Ruiz del Arbol P., Matorras F., Matorras Cuevas P., Navarrete Ramos E., Piedra Gomez J., Prieels C., Scodellaro L., Vila I., Vizan Garcia J. M., Jayananda M. K., Kailasapathy B., Sonnadara D. U. J., Wickramarathna D. D. C., Dharmaratna W. G. D., Liyanage K., Perera N., Wickramage N., Abbaneo D., Amendola C., Auffray E., Auzinger G., Baechler J., Barney D., Bermudez Martinez A., Bianco M., Bilin B., Bin Anuar A. A., Bocci A., Brondolin E., Caillol C., Camporesi T., Cerminara G., Chernyavskaya N., d'Enterria D., Dabrowski A., David A., De Roeck A., Defranchis M. M., Deile M., Dobson M., Fallavollita F., Forthomme L., Franzoni G., Funk W., Giani S., Gigi D., Gill K., Glege F., Gouskos L., Haranko M., Hegeman J., Innocente V., James T., Janot P., Kieseler J., Laurila S., Lecoq P., Leutgeb E., Lourenco C., Maier B., Malgeri L., Mannelli M., Marini A. C., Meijers F., Mersi S., Meschi E., Milosevic V., Moortgat F., Mulders M., Orfanelli S., Pantaleo F., Peruzzi M., Petrucciani G., Pfeiffer A., Pierini M., Piparo D., Qu H., Rabady D., Reales Gutierrez G., Rovere M., Sakulin H., Scarfi S., Selvaggi M., Shchelina K., Silva P., Sphicas P., Stahl Leiton A. G., Steen A., Summers S., Treille D., Tropea P., Tsirou A., Walter D., Wanczyk J., Wozniak K. A., Zehetner P., Zejdl P., Zeuner W. D., Bevilacqua T., Caminada L., Ebrahimi A., Erdmann W., Horisberger R., Ingram Q., Kaestli H. C., Kotlinski D., Lange C., Missiroli M., Noehte L., Rohe T., Aarrestad T. K., Androsov K., Backhaus M., Calandri A., Cazzaniga C., Datta K., De Cosa A., Dissertori G., Dittmar M., Donega M., Eble F., Galli M., Gedia K., Glessgen F., Grab C., Hits D., Lustermann W., Lyon A. -M., Manzoni R. A., Marchegiani M., Marchese L., Martin Perez C., Mascellani A., Nessi-Tedaldi F., Pauss F., Perovic V., Pigazzini S., Ratti M. G., Reichmann M., Reissel C., Reitenspiess T., Ristic B., Riti F., Ruini D., Sanz Becerra D. A., Seidita R., Steggemann J., Valsecchi D., Wallny R., Amsler C., Bartschi P., Botta C., Brzhechko D., Canelli M. F., Cormier K., Del Burgo R., Heikkila J. K., Huwiler M., Jin W., Jofrehei A., Kilminster B., Leontsinis S., Liechti S. P., Macchiolo A., Meiring P., Mikuni V. M., Molinatti U., Neutelings I., Reimers A., Robmann P., Sanchez Cruz S., Schweiger K., Senger M., Takahashi Y., Adloff C., Kuo C. M., Lin W., Rout P. K., Tiwari P. C., Yu S. S., Ceard L., Chao Y., Chen K. F., Chen P. S., Chen Z. G., Hou W. -S., Hsu T. H., Kao Y. W., Khurana R., Kole G., Li Y. Y., Lu R. -S., Paganis E., Psallidas A., Su X. F., Thomas-Wilsker J., Wu H. Y., Yazgan E., Asawatangtrakuldee C., Srimanobhas N., Wachirapusitanand V., Agyel D., Boran F., Demiroglu Z. S., Dolek F., Dumanoglu I., Eskut E., Guler Y., Gurpinar Guler E., Isik C., Kara O., Kayis Topaksu A., Kiminsu U., Onengut G., Ozdemir K., Polatoz A., Tali B., Tok U. G., Turkcapar S., Uslan E., Zorbakir I. S., Ocalan K., Yalvac M., Akgun B., Atakisi I. O., Gulmez E., Kaya M., Kaya O., Tekten S., Cakir A., Cankocak K., Komurcu Y., Sen S., Aydilek O., Cerci S., Epshteyn V., Hacisahinoglu B., Hos I., Isildak B., Kaynak B., Ozkorucuklu S., Potok O., Sert H., Simsek C., Sunar Cerci D., Zorbilmez C., Boyaryntsev A., Grynyov B., Levchuk L., Anthony D., Brooke J. J., Bundock A., Bury F., Clement E., Cussans D., Flacher H., Glowacki M., Goldstein J., Heath H. F., Kreczko L., Krikler B., Paramesvaran S., Seif El Nasr-Storey S., Smith V. J., Stylianou N., Walkingshaw Pass K., White R., Ball A. H., Bell K. W., Belyaev A., Brew C., Brown R. M., Cockerill D. J. A., Cooke C., Ellis K. V., Harder K., Harper S., Holmberg M. -L., Linacre J., Manolopoulos K., Newbold D. M., Olaiya E., Petyt D., Reis T., Salvi G., Schuh T., Shepherd-Themistocleous C. H., Tomalin I. R., Williams T., Bainbridge R., Bloch P., Brown C. E., Buchmuller O., Cacchio V., Carrillo Montoya C. A., Chahal G. S., Colling D., Dancu J. S., Dauncey P., Davies G., Davies J., Della Negra M., Fayer S., Fedi G., Hall G., Hassanshahi M. H., Howard A., Iles G., Knight M., Langford J., Lyons L., Magnan A. -M., Malik S., Martelli A., Mieskolainen M., Nash J., Pesaresi M., Radburn-Smith B. C., Richards A., Rose A., Seez C., Shukla R., Tapper A., Uchida K., Uttley G. P., Vage L. H., Virdee T., Vojinovic M., Wardle N., Winterbottom D., Coldham K., Cole J. E., Khan A., Kyberd P., Reid I. D., Abdullin S., Brinkerhoff A., Caraway B., Dittmann J., Hatakeyama K., Hiltbrand J., Kanuganti A. R., McMaster B., Saunders M., Sawant S., Sutantawibul C., Toms M., Wilson J., Bartek R., Dominguez A., Huerta Escamilla C., Simsek A. E., Uniyal R., Vargas Hernandez A. M., Chudasama R., Cooper S. I., Gleyzer S. V., Perez C. U., Rumerio P., Usai E., West C., Yi R., Akpinar A., Albert A., Arcaro D., Cosby C., Demiragli Z., Erice C., Fontanesi E., Gastler D., Rohlf J., Salyer K., Sperka D., Spitzbart D., Suarez I., Tsatsos A., Yuan S., Benelli G., Coubez X., Cutts D., Hadley M., Heintz U., Hogan J. M., Kwon T., Landsberg G., Lau K. T., Li D., Luo J., Mondal S., Narain M., Pervan N., Sagir S., Simpson F., Stamenkovic M., Wong W. Y., Yan X., Zhang W., Abbott S., Bonilla J., Brainerd C., Breedon R., Calderon De La Barca Sanchez M., Chertok M., Citron M., Conway J., Cox P. T., Erbacher R., Haza G., Jensen F., Kukral O., Mocellin G., Mulhearn M., Pellett D., Regnery B., Wei W., Yao Y., Zhang F., Bachtis M., Cousins R., Datta A., Hauser J., Ignatenko M., Iqbal M. A., Lam T., Manca E., Nash W. A., Saltzberg D., Stone B., Valuev V., Clare R., Gordon M., Hanson G., Si W., Wimpenny S., Branson J. G., Cittolin S., Cooperstein S., Diaz D., Duarte J., Gerosa R., Giannini L., Guiang J., Kansal R., Krutelyov V., Lee R., Letts J., Masciovecchio M., Mokhtar F., Pieri M., Quinnan M., Sathia Narayanan B. V., Sharma V., Tadel M., Vourliotis E., Wurthwein F., Xiang Y., Yagil A., Barzdukas A., Brennan L., Campagnari C., Collura G., Dorsett A., Incandela J., Kilpatrick M., Li A. J., Masterson P., Mei H., Oshiro M., Richman J., Sarica U., Schmitz R., Setti F., Sheplock J., Stuart D., Wang S., Bornheim A., Cerri O., Latorre A., Lawhorn J. M., Mao J., Newman H. B., Nguyen T. Q., Spiropulu M., Vlimant J. R., Xie S., Zhu R. Y., Alison J., An S., Andrews M. 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S., Zarubin A., Zhizhin I., and Zhokin A.
Abstract: A search for an exotic decay of the Higgs boson to a Z boson and a light pseudoscalar particle (a), decaying to a pair of leptons and a pair of photons, respectively, is presented. The search is based on proton-proton collision data at a center-of-mass energy of s=13TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 138fb−1. The analysis probes pseudoscalar masses ma between 1 and 30 GeV, leading to two pairs of well-isolated leptons and photons. Upper limits at 95% confidence level are set on the Higgs boson production cross section times its branching fraction to two leptons and two photons. The observed (expected) limits are in the range of 1.1–17.8 (1.7–17.9) fb within the probed ma interval. An excess of data above the expected standard model background with a local (global) significance of 2.6 (1.3) standard deviations is observed for a mass hypothesis of ma=3GeV. Limits on models involving axion-like particles, formulated as an effective field theory, are also reported.
Published: 2024

47. Beam monitoring detectors for High Intensity Muon Beams

Author: Dal Maso, G., Barchetti, F., Francesconi, M., Galli, L., Greuter, U., Hildebrandt, M., Hofer, A., Kettle, P.-R., Knecht, A., Künzi, L., Ritt, S., Stoykov, A., Valetov, E., and Papa, A.
Published: 2023
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48. Characteristics of conjunctival myxomas on anterior segment optical coherence tomography.

Author: Feng, Paula W., Herskowitz, William R., Tang, Vincent, Khzam, Rayan Abou, Dubovy, Sander R., Galor, Anat, and Karp, Carol L.
Published: 2024
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49. Water-soluble amino acid derivatives isolated from cultures of three fungal strains.

Author: Gotha, Matheus, Junqueira, Gabriel C., Bertonha, Ariane F., Rodríguez, Julie P.G., Gubiani, Juliana R., Pissinati, Emanuele F., Lima, Rafaely N., Sette, Lara D., de Lira, Simone P., Oliveira, Luciane F.P., Batista, Andrea N.L., Batista, João M., Ferreira, Antonio G., Paixão, Márcio W., Amorim, Marcelo R., and Berlinck, Roberto G.S.
Abstract: The isolation of amino acid-derived metabolites from the aqueous fractions of cultures of three fungal strains is reported. From cultures of Penicillium coffeae M3 two β-carboline alkaloids were isolated and identified, the new (+)-(1 R ,3 R)-1-methyl-1,2,3,4-tetrahydro- β -carboline-3-carboxylic acid (1) and the known (–)-lycoperodine-1 (2), along with the diketopiperazine cyclo [ l -prolyl- l -tyrosyl] (3) and the isocoumarin 6,8-dihydroxy-3-methylisocoumarin (5). The diketopiperazines (3), cyclo [ d -prolyl- l -phenylalanyl] (4) and cyclo [ l -prolyl- l -phenylalanyl] (6) were isolated and identified from cultures of Trichoderma sp. L2–2. The peptaibol trichokonin VI (7) was also identified by UPLC-MS/MS analysis in aqueous fractions from cultures of the same Trichoderma sp. strain, by comparison with an authentic standard, isolated and identified from the organic fraction of the same fungus culture. The amino acid derivatives formyl- l -tryptophyl- l -alanine (8), cyclo -(d -Trp- l -Glu) (9), and (S)- N -acetyl-kynurenine (10), were isolated from cultures of the endophytic fungus Paecilomyces sp. Aa1. The planar structures of the amino acid derivatives 1 - 4 , 6 , 8 - 10 , as well as of the isocoumarin 5 , were established by analysis of spectroscopic data, including MS/MS fragmentation and comparison with literature data. The configurational assignments were performed by analysis of Marfey derivatives and/or by comparison between experimental and calculated ECD data. The results obtained give further support that investigation of aqueous fractions of fungal cultures may provide structurally relevant and potentially bioactive secondary metabolites. [Display omitted] • One new and one known β-carboline alkaloid were isolated from cultures of Penicillium coffeae M3. • Two diketopiperazines and trichokonin VI (7) were isolated from cultures of a Trichoderma sp. strain. • New formyl-l-tryptophyl-l-alanine, cyclo-(d -Trp- l -Glu) and (S)- N -acetyl-kynurenine were produced by Paecilomyces sp. • Configurations of all metabolites were assigned by Marfey's analysis and by analysis of ECD data. • Aqueous fractions of fungal cultures may provide structurally relevant secondary metabolites. [ABSTRACT FROM AUTHOR]
Published: 2024
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50. Integrating skin color assessments into clinical practice and research: A review of current approaches.

Author: Harvey, Valerie M., Alexis, Andrew, Okeke, Chidubem A.V., McKinley-Grant, Lynn, Taylor, Susan C., Desai, Seemal R., Jaleel, Tarannum, Heath, Candrice R., Kang, Sewon, Vashi, Neelam, Lester, Jenna, Vasquez, Rebecca, Rodrigues, Michelle, Elbuluk, Nada, Hamzavi, Iltefat, Kwatra, Shawn G., Sundaram, Hema, Cobb, Caryn, Brown III, Stafford G., and Kohli, Indermeet
Abstract: Skin color classification can have importance in skin health, pigmentary disorders, and oncologic condition assessments. It is also critical for evaluating disease course and response to a variety of therapeutic interventions and aids in accurate classification of participants in clinical research studies. A panel of dermatologists conducted a literature review to assess the strengths and limitations of existing classification scales, as well as to compare their preferences and utilities. We identified 17 skin classification systems utilized in dermatologic settings. These systems include a range of parameters such as UV light reactivity, race, ethnicity, and degree of pigmentation. The Fitzpatrick skin type classification is most widely used and validated. However it has numerous limitations including its conflation with race, ethnicity, and skin color. There is a lack of validation data available for the remaining scales. There are significant deficiencies in current skin classification instruments. Consensus-based initiatives to drive the development of validated and reliable tools are critically needed. [ABSTRACT FROM AUTHOR]
Published: 2024
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