Search

Bisphenol A (BPA) is an endocrine-disrupting compound that may interfere with the function of thyroid systems. Sensitive and reliable detection of BPA has become one of the most pressing environmental issues related to the consequences of plastics on human health. This work reports the development of an electrochemical sensor based on molecularly imprinted polymer (MIP) prepared using BPA as a template, 2-Hydroxyethyl methacrylate (HEMA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a crosslinker with a ratio (1:2:30), respectively. The MIP was incorporated in carbon paste electrode (CPE) modified with multiwalled carbon nanotubes (MWCNT). The stepwise topography during the electrode fabrication steps was confirmed using scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR). While, differential pulse voltammetry (DPV), Cyclic Voltammetry (CV) and electrochemical (EIS) impedance spectroscopy were used to investigate the electrochemical response. Linearity was validated within the working dynamic range 1 × 10−10 to 1 × 10−4 M (0.023–23 ×103 ng/mL) was observed with a detection limit of 8 × 10−11 M (0.02 ng/mL) and a limit of quantification of 2.4 × 10−10 M (0.05 ng/mL). BPA was successfully tested in tap water, stored water in a baby bottle, filtered water (water from household purification unit), and soft drink samples with recovery ranges 97.60–102.0% with RSD values 0.37–2.45% indicating the possible applicability of the electrode in real samples. [Display omitted] • Hydroxyethyl methacrylate (HEMA) were applied for the first time for BPA imprinting. • A MIP based MWCNT/CPE was optimized. • A linear response range of 1 × 10−10 to 1 × 10−4 M (0.023–23 ×103 ng mL−1) was attained. • Detection limit of 0.08 × 10−9 M (0.02 ng mL−1) was obtained. • LOD is l lower than that indicated as hazardous by FDA or EFSA (50 µg/Kg/day). [ABSTRACT FROM AUTHOR]

Introduction of tetrazolate moiety in the coordination sphere of Pd(II) complex, functionalized with tridentate benzimidazole ligand, via the catalyst [3+2] cycloaddition reaction, gave rise to potential antibacterial properties. [Display omitted] Two [PdN 3 L]PF 6 complexes (L = 2,6-bis(1-ethyl-benzimidazol-2́-yl)pyridine (LBZ) and 4-(2-pyridyl)-2,2′:6′,2′'-terpyridine (LPY)) underwent catalyst-free 1,3-dipolar cycloaddition coupling with phenyl isothiocyanate at the room temperature giving the corresponding tetrazole–thiolato complexes. 1H NMR studies showed that the N1-isomer appeared first in the catalyst-free coupling, then gradually isomerized to the more stable tetrazole–thiolato isomer. The interconversion of N1-isomer into the S-isomer is accompanied by a decrease of the greater steric demand of the 5-membered ring. Tetrazolate complex of LBZ displayed higher antifungal activity (MIC ≤ 0.25 μg/mL) than the chloride analogue (MIC = 0.5–1.0 μg/mL) and the reference drug, Fluconazole (MIC = 0.125–8.0 μg/mL) against Candida albicans and Cryptococcus neoformans. The treated non-cancerous human embryonic kidney cells (HEK293) showed no cytotoxicity and no haemolysis release at the measured concentrations of the chloride complex of LBZ and tetrazolate complex of LPY. [ABSTRACT FROM AUTHOR]

The titled carbon monoxide releasing molecule is capable of release CO upon illumination at 468 nm and demonstrates selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells. [Display omitted] The reaction between bromo pentacarbonyl manganese(I) and two equivalents of 1-(chloromethyl)-1H-benzotriazole (BTZ-CH 2 Cl) afforded visible-light induced carbon monoxide releasing molecule of the general formula, fac -[MnBr(CO) 3 (BTZ-CH 2 Cl) 2 ]. The solvatochromism, dark-stability and photolysis profile of the titled complex was examined in organic solvents with various hydrogen-bonding propensities, coordinating capabilities, and solvent polarities as well as in the presence of proteins. The number of CO equivalents released from the titled complex upon the exposure to a 468 nm LED light was determined using myoglobin assay. The titled complex displayed selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells. [ABSTRACT FROM AUTHOR]