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Start Over Author "Okamoto, T." Publisher elsevier b.v.
279 results on '"Okamoto, T."'

43. Early Weight Gain During Ex Vivo Lung Perfusion Can Predict Transplant Suitability and Post-Transplant Outcomes.

Author

Sakanoue, I., Okamoto, T., Ayyat, K.S., Tantawi, A., Yun, J.J., Niikawa, H., and McCurry, K.R.

Subjects
*WEIGHT gain, *TREATMENT effectiveness, *PERFUSION, *LUNGS, *TRANSPLANTATION of organs, tissues, etc.
Abstract

Real-time lung weight measurement is a simple and non-invasive technique to detect extravascular lung water during ex vivo lung perfusion (EVLP). We aimed to investigate the feasibility of real-time lung weight measurement in clinical EVLP as an early predictor of transplant suitability and post-transplant outcomes. In our clinical acellular EVLP system, real-time lung weight was measured in 117 cases, from 6/2019 to 6/2022. Weights were repeatedly recorded with a scale under the organ chamber throughout the perfusion. Estimated lung weight gain at each time point was calculated by cumulative estimated lung weight up to that time point. According to our recent data on lung weight, 4 categories using adjusted lung weight before starting EVLP (Ad-LW0), Ad-LW0 was calculated as follows: Ad-LW0 [g] = Lung weight before EVLP [g] + (175 - donor height [cm]) × 11.07, Category1: the lowest weight, Category 4: the highest weight). Non-suitable cases (n = 39) had significantly higher estimated lung weight gain than suitable cases (n = 78) throughout the perfusion (Figure A). Estimated lung weight gain at 10 mins and 60 mins were significantly higher in non-suitable cases in each Ad-LW0 category (Figure B, C). Specifically, the area under the receiver-operating characteristic curve to identify transplant non-suitability in category 4 was 0.81 for estimated lung weight gain at 10 mins (cut-off value: -43.6 g) and 0.89 for 60 mins (cut-off value: -1.3 g). In transplanted cases, estimated lung weight gain at 60 min was significantly higher in PGD 2-3 cases (n = 16) than PGD 0-1 cases (n = 58) (1.3 ± 53.0 vs -42.9 ± 52.1 [g], p < 0.05) with 4 ungradable cases. Early weight gain during EVLP using real-time lung weight measurement can predict transplant suitability and post-transplant outcomes. Abnormal value of real-time lung weight data has a specific role as an early alarm for any potential evidence of poor lung function during evaluation and post-transplant period. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Pathological factors involved in local failure in squamous cell carcinoma of the oral cavity: retrospective study and proposal of a new clinical classification.

Author

Toratani, S., Yoshioka, Y., Okamoto, T., Ogawa, I., Sasahara, H., Kanda, T., and Tani, R.

Subjects
SQUAMOUS cell carcinoma, DYSPLASIA, CLASSIFICATION, RETROSPECTIVE studies
Abstract

Abstract The control of local failure (LF) is essential to improve outcomes in patients with squamous cell carcinoma of the oral cavity (OSCC). In this study, LF of OSCC was classified into three clinical types: deep recurrence (type 1R), adjacent superficial recurrence (type 2R), and distant primary tumour (type 3R). LF was analyzed after surgical resection of OSCC to determine the validity and usefulness of this classification system. Of 257 patients with OSCC, 58 experienced LF; 21 had type 1R, 23 had type 2R, and 20 had type 3R. Clinical factors influencing LF were analyzed by log-rank test and Cox test. Type 1R was significantly related to the TN classification, resection margin status, and invasive pattern. Type 2R was strongly associated with the grade of epithelial dysplasia at the surgical margins. Type 1R rarely developed more than 1 year after surgery, whereas type 2R did not develop within 2 years. Type 1R may be caused by residual cancer cells in the deep margins, and type 2R by precancerous cells remaining in the marginal epithelium and gradually becoming invasive cancer. Type 3R may be considered an independent tumour. The newly proposed clinical classification is convenient and roughly reflects the causes and mechanisms of relapse. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Metastasis of carcinoma ex pleomorphic adenoma to the brain without previous metastasis to the lungs or bones: a case report.

Author

Yoshioka, Y., Hayashi, S., Hamada, A., Toratani, S., and Okamoto, T.

Subjects
SALIVARY gland cancer, CARCINOMA, METASTASIS, BRAIN metastasis, ADENOMA
Abstract

Carcinoma ex pleomorphic adenoma is a rare type of cancer of the salivary gland that involves the malignant transformation of a primary or recurrent pleomorphic adenoma, which often metastasises to the lungs or bones, or both. To the best of our knowledge, however, nobody has reported a distant metastasis of this lesion to the brain without such previous metastasis. We report a case in a 64-year-old man. [ABSTRACT FROM AUTHOR]

Published
2019
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48. Dissolved oxygen transfer into a square embayment connected to an open-channel flow.

Author

Sanjou, M., Okamoto, T., and Nezu, I.

Subjects
*DISSOLVED oxygen in water, *OPTICAL apertures, *HEAT transfer, *HYDRAULICS, *FLUID mechanics
Abstract

We have conducted field and laboratory experiments to determine the rates of processes responsible for the recovery of dissolved oxygen (DO) in an embayment connected to a main channel. We measured the horizontal velocity vectors to evaluate large-scale circulation within the embayment and measured the time series of DO concentrations during the recovery processes promoted by supply from the main channel. In particular, this study has focused on the effects of the aperture ratio of the embayment/main-channel opening. We have developed a practical formula for the DO recovery rate based on the bulk-mean velocity in the main channel, the aperture ratio, and the position of the embayment opening. [ABSTRACT FROM AUTHOR]

Published
2018
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