16 results on '"Northrup, Thomas F."'
Search Results
2. Facilitating treatment initiation and reproductive care postpartum to prevent substance-exposed pregnancies: A randomized bayesian pilot trial
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Stotts, Angela L., Villarreal, Yolanda R., Green, Charles, Berens, Pamela, Blackwell, Sean, Khan, Amir, Suchting, Robert, Velasquez, Mary, Markham, Christine, Klawans, Michelle R., and Northrup, Thomas F.
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- 2022
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3. Prevalence and treatment of opioid use disorders among primary care patients in six health systems
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Ahmedani, Brian, Amoroso, Paul J., Arnsten, Julia H., Bart, Gavin, Braciszewski, Jordan M., Cunningham, Chinazo O., Hechter, Rulin C., Horigian, Viviana E., Liebschutz, Jane M., Loree, Amy M., Matson, Theresa E., McNeely, Jennifer, Merrill, Joseph O., Northrup, Thomas F., Schwartz, Robert P., Stotts, Angela L., Szapocznik, José, Thakral, Manu, Tsui, Judith I., Zare, Mohammad, Lapham, Gwen, Boudreau, Denise M., Johnson, Eric A., Bobb, Jennifer F., Matthews, Abigail G., McCormack, Jennifer, Liu, David, Samet, Jeffrey H., Saxon, Andrew J., Campbell, Cynthia I., Glass, Joseph E., Rossom, Rebecca C., Murphy, Mark T., Binswanger, Ingrid A., Yarborough, Bobbi Jo H., and Bradley, Katharine A.
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- 2020
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4. A Brief, Hospital-Initiated Motivational Interviewing and Acceptance and Commitment Therapy Intervention to Link Postpartum Mothers Who Use Illicit Drugs With Treatment and Reproductive Care: A Case Report.
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Villarreal, Yolanda R., Spellman, Mackenzie L., Prudon, Jasmin, Northrup, Thomas F., Berens, Pamela D., Blackwell, Sean, Velasquez, Mary M., and Stotts, Angela L.
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ACCEPTANCE & commitment therapy ,MOTIVATIONAL interviewing ,SUBSTANCE abuse ,DRUG abuse ,DRUGS of abuse ,PUERPERAL disorders ,PERINATAL mood & anxiety disorders - Abstract
Maternal substance use during the prenatal period often results in infants with compromised health outcomes. The American College of Obstetrics and Gynecology recommends screening, brief motivational interviewing, and referral to existing treatment for women who use illicit substances prenatally. However, many of these women do not present for prenatal care and are not identified as using substances until delivery of their infants, many of whom are admitted to the neonatal intensive care unit (ICU). We describe a case from a novel, hospital-initiated intervention study, Moms in ACTion (MIACT) that combines motivational interviewing (MI) and acceptance and commitment therapy (ACT) to target new mothers with an infant in the neonatal ICU who screen positive for illicit substance use prenatally or at delivery. The MIACT program consists of an adaptive intervention that includes up to three sessions. Initiation of substance use treatment and reproductive care via a gynecological visit are the primary targets of the intervention. Urine samples were collected at 2- and 6-month follow-up visits. The participant successfully completed the program, achieved both treatment outcomes, and had negative urine drug screens at follow-up visits. Improvements in readiness to change and psychological flexibility were also observed. The present case report of a new mother who used substances demonstrated feasibility for combining MI and ACT treatments and the potential for MIACT to increase treatment and contraception initiation, ultimately preventing future substance-exposed pregnancies. • Infants exposed to illicit substances (IEIS) prenatally have severe health consequences. • Women who use illicit drugs prenatally (WWUIDP) often do not seek prenatal care or treatment. • Hospital-initiated interventions linking WWUIDP with treatment/reproductive care may prevent future IEIS. • MIACT is well suited to aid WWUIDP cope with distressing processes associated with drug use. • Hospital-initiated MIACT demonstrates initial feasibility and effectiveness to link women with IEIS to treatment/reproductive care. [ABSTRACT FROM AUTHOR]
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- 2021
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5. Proactive delivery of nicotine replacement therapy to families of hospitalized infants in a NICU: A randomized controlled pilot trial.
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Northrup, Thomas F., Suchting, Robert, Klawans, Michelle R., Khan, Amir M., Villarreal, Yolanda R., Green, Charles, and Stotts, Angela L.
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- 2020
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6. An ounce of prevention: A pre-randomization protocol to improve retention in substance use disorder clinical trials.
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Northrup, Thomas F., Greer, Tracy L., Walker, Robrina, Rethorst, Chad D., Warden, Diane, Stotts, Angela L., and Trivedi, Madhukar H.
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SUBSTANCE abuse prevention , *SUBSTANCE abuse research , *SUBSTANCE abuse treatment , *MEDICAL protocols , *RANDOMIZATION (Statistics) , *CLINICAL trials , *COMPARATIVE studies , *EXPERIMENTAL design , *RESEARCH methodology , *MEDICAL cooperation , *PATIENT compliance , *RESEARCH , *RESEARCH funding , *EVALUATION research , *RANDOMIZED controlled trials , *HUMAN research subjects - Abstract
Background: Missing data in substance use disorder (SUD) research pose a significant threat to internal validity. Participants terminate involvement or become less likely to attend intervention and research visits for many reasons, which should be addressed prior to becoming problematic. During a 9-month study targeting stimulant abuse, early dropouts and participant reported attendance barriers led to implementing a structured, pre-randomization protocol with participants about retention and solution-focused strategies (the "Fireside Chat"). Our aim is to outline this approach and present data on intervention participation and research visit attendance after implementation.Methods/design: STimulant Reduction using Dosed Exercise (STRIDE) was a two-arm, multisite randomized clinical trial testing treatment-as-usual for stimulant abuse/dependence augmented by Exercise or Health Education. For both groups, study intervention visits at the site were scheduled 3/week for 12weeks followed by 1/week for 24weeks. During The Chat, research staff thoroughly reviewed participants' expectations, and barriers and solutions to retention. Fifteen participants were randomized (to Exercise or Health Education) prior to and fourteen were randomized after Chat implementation. Intervention and monthly follow-up attendance (before and after implementation) were compared at the site (N=29) that developed and rigorously implemented The Chat.Results: Individuals who participated in The Chat (n=14) attended significantly more intervention visits during weeks 1-12 (p<0.001) and weeks 13-36 (p<0.05) and attended more research visits (p<0.001).Discussion: Proactive discussion of expectations and barriers prior to randomization was associated with greater study attendance. SUD researchers should consider tailoring this approach to suit their needs. Further investigation is warranted. [ABSTRACT FROM AUTHOR]- Published
- 2017
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7. On the invariance of the Stimulant Craving Questionnaire (STCQ) across cocaine and methamphetamine users.
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Northrup, Thomas F., Green, Charles, Walker, Robrina, Greer, Tracy L., and Trivedi, Madhukar H.
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STIMULANTS , *COCAINE abuse , *METHAMPHETAMINE abuse , *METHAMPHETAMINE , *QUESTIONNAIRES - Abstract
Background The rapid rise in the number of methamphetamine users, relative to cocaine users, has brought the number of each to nearly equal levels, making research on similarities and differences across these groups a needed area of exploration. Craving is postulated to play a significant role in relapse for both user types, yet group differences on observed scale scores have been reported without first assessing the prerequisite measurement equivalence (invariance) of the items, which is essential for meaningful group comparisons. Methods/design Baseline data from stimulant users in residential treatment (N = 301; n = 177 cocaine; n = 124 methamphetamine) were used to assess the measurement invariance of the 10-item Stimulant Craving Questionnaire (STCQ), which was adapted from a cocaine-specific measure. Results The unifactorial STCQ demonstrated measurement invariance across cocaine and methamphetamine users for factor loadings (metric), common residual covariances between item pairs, and item intercepts (scalar), as determined by fit indices (RMSEA < 0.05; CFI & TLI > 0.95; SRMR < 0.10). The latent mean, as well as 5 (out of 10) item means and the overall composite scale score, was significantly greater for methamphetamine users compared to cocaine users. Discussion Results indicate the STCQ is an invariant tool for the assessment of stimulant craving across the two most prevalent user types. Methamphetamine users had significantly higher levels of observed and latent craving than cocaine users, demonstrating a potentially meaningful difference in craving between users of these two stimulants. Future research will determine if treatments and statistical models need to account for craving variations across methamphetamine and cocaine users. [ABSTRACT FROM AUTHOR]
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- 2015
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8. Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: A discrete survival and growth mixture model.
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Northrup, Thomas F., Stotts, Angela L., Green, Charles, Potter, Jennifer S., Marino, Elise N., Walker, Robrina, Weiss, Roger D., and Trivedi, Madhukar
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OPIOIDS , *DETOXIFICATION (Substance abuse treatment) , *CLASS analysis , *BUPRENORPHINE , *SUBSTANCE abuse - Abstract
Introduction Most patients relapse to opioids within one month of opioid agonist detoxification, making the antecedents and parallel processes of first use critical for investigation. Craving and withdrawal are often studied in relationship to opioid outcomes, and a novel analytic strategy applied to these two phenomena may indicate targeted intervention strategies. Methods Specifically, this secondary data analysis of the Prescription Opioid Addiction Treatment Study used a discrete-time mixture analysis with time-to-first opioid use (survival) simultaneously predicted by craving and withdrawal growth trajectories. This analysis characterized heterogeneity among prescription opioid-dependent individuals (N = 653) into latent classes (i.e., latent class analysis [LCA]) during and after buprenorphine/naloxone stabilization and taper. Results A 4-latent class solution was selected for overall model fit and clinical parsimony. In order of shortest to longest time-to-first use, the 4 classes were characterized as 1) high craving and withdrawal, 2) intermediate craving and withdrawal, 3) high initial craving with low craving and withdrawal trajectories and 4) a low initial craving with low craving and withdrawal trajectories. Odds ratio calculations showed statistically significant differences in time-to-first use across classes. Conclusions Generally, participants with lower baseline levels and greater decreases in craving and withdrawal during stabilization combined with slower craving and withdrawal rebound during buprenorphine taper remained opioid-free longer. This exploratory work expanded on the importance of monitoring craving and withdrawal during buprenorphine induction, stabilization, and taper. Future research may allow individually tailored and timely interventions to be developed to extend time-to-first opioid use. [ABSTRACT FROM AUTHOR]
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- 2015
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9. Baby's Breath II protocol development and design: A secondhand smoke exposure prevention program targeting infants discharged from a neonatal intensive care unit.
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Stotts, Angela L., Northrup, Thomas F., Schmitz, Joy M., Green, Charles, Tyson, Jon, Velasquez, Mary M., Khan, Amir, and Hovell, Melbourne F.
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GYPSOPHILA paniculata , *MEDICAL protocols , *PASSIVE smoking , *NEWBORN infant care , *INTENSIVE care units , *HOSPITAL admission & discharge , *PREMATURE infants , *CLINICAL trials - Abstract
Abstract: Background: Over one-third of all children live with at least one parent who smokes cigarettes, which is associated with compromised child health. The impact of secondhand smoke exposure (SHSe) in medically fragile infants born prematurely is likely to be much higher. The Baby's Breath II study tests whether a hospital-initiated, motivational-enhancement program will result in less SHSe relative to conventional care in high-risk, low birthweight (LBW) infants discharged from a neonatal intensive care unit (NICU). The design and protocol for the ongoing BBII trial is described. Methods/design: Eligible participants are: (1) primary caregivers (typically mothers) of NICU infants who were born at LBW (<2500g) or ventilated for more than 12h; and (2) who smoke or live with at least one smoker. This randomized controlled trial has two conditions: Motivational interviewing plus incentives (MI+) and conventional care (CC). MI+ participants receive two hospital-based and two home-based counseling sessions, as well as incentives (i.e., prize-based draws) for (a) intervention attendance and (b) biochemical validation (i.e., urine cotinine dipstick) indicative of low or no infant SHSe. Participants in the control group receive conventional education-based care. Assessments are completed at baseline, mid-point, and 1- and 4-months post-intervention. Discussion: This study is the first to determine the efficacy of a brief intervention for reducing SHSe among high-risk, LBW infants discharged from a NICU, with the potential for saving lives and healthcare costs. Strengths, limitations and challenges to the conduct of this trial are discussed. [Copyright &y& Elsevier]
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- 2013
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10. Initiation and persistence of alcohol use in United States Black, Hispanic, and White male and female youth
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Malone, Patrick S., Northrup, Thomas F., Masyn, Katherine E., Lamis, Dorian A., and Lamont, Andrea E.
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ALCOHOL drinking , *UNDERAGE drinking , *HISPANIC American youth , *AFRICAN American youth , *BLACK youth , *WHITE youth , *SOCIODEMOGRAPHIC factors , *ALCOHOLISM , *GENDER differences (Sociology) - Abstract
Background: The relation between early and frequent alcohol use and later difficulties is quite strong. However, the degree that alcohol use persists, which is often a necessary cause for developing alcohol-related problems or an alcohol use disorder, is not well studied, particularly with attention to race and gender. A novel statistical approach, the Multi-facet Longitudinal Model, enables the concurrent study of age of initiation and persistence. Methods: The models were applied to longitudinal data on youth alcohol use from ages 12 through 19, collected in the (U.S.) National Longitudinal Survey of Youth 1997 cohort (N =8984). Results: Results confirmed that Black adolescents initiate alcohol use at later ages than do White youth. Further, after initiation, White adolescents were substantially more likely than Black adolescents to continue reporting alcohol use in subsequent years. Hispanic teens showed an intermediate pattern. Gender differences were more ambiguous, with a tendency for boys to be less likely to continue drinking after initiation than were girls. Conclusions: Novel findings from the new analytic models suggest differential implications of early alcohol use by race and gender. Early use of alcohol might be less consequential for males who initiate alcohol use early, Black, and Hispanic youth than for their female and White counterparts. [Copyright &y& Elsevier]
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- 2012
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11. Decreasing vancomycin utilization in a neonatal intensive care unit.
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Holzmann-Pazgal, Galit, Khan, Amir M., Northrup, Thomas F., Domonoske, Christine, and Eichenwald, Eric C.
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This study evaluated the efficacy of education versus audit and feedback in decreasing vancomycin utilization. Data were collected prospectively from October 1, 2012-April 30, 2014 over the following 3 periods: baseline, after education and introduction of a late-onset sepsis treatment guideline, and after prospective audit-feedback to physicians. Vancomycin utilization and administration duration >3 days significantly decreased with education and guideline use, but it was not affected by addition of audit and feedback. [ABSTRACT FROM AUTHOR]
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- 2015
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12. Reducing Tobacco Smoke Exposure in High-Risk Infants: A Randomized, Controlled Trial.
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Stotts, Angela L., Northrup, Thomas F., Green, Charles, Suchting, Robert, Hovell, Melbourne F., Khan, Amir, Villarreal, Yolanda R., Schmitz, Joy M., Velasquez, Mary M., Hammond, S. Katharine, Hoh, Eunha, and Tyson, Jon
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Objective: To evaluate a hospital-initiated intervention to reduce tobacco smoke exposure in infants in the neonatal intensive care unit.Study Design: A randomized, controlled trial compared motivational interviewing plus financial incentives with conventional care on infant urine cotinine at 1 and 4 months' follow-up. Mothers of infants in the neonatal intensive care unit (N = 360) who reported a smoker living in the home were enrolled. Motivational interviewing sessions were delivered in both the hospital and the home. Financial incentives followed session attendance and negative infant cotinine tests postdischarge.Results: The intervention effect on infant cotinine was not significant, except among mothers who reported high baseline readiness/ability to protect their infant (P ≤ .01) and mothers who completed the study within 6 months postdischarge (per protocol; P ≤ .05). Fewer mothers in the motivational interviewing plus financial incentives condition were smoking postdischarge (P ≤ .01). More mothers in the motivational interviewing plus financial incentives group reported a total home and car smoking ban at follow-up (P ≤ .05).Conclusions: Motivational interviewing combined with financial incentives reduced infant tobacco smoke exposure in a subset of women who were ready/able to protect their infant. The intervention also resulted in less maternal smoking postpartum. More robust interventions that include maternal and partner/household smoking cessation are likely needed to reduce the costly effects of tobacco smoke exposure on children and their families.Trial Registration: ClinicalTrials.gov: NCT01726062. [ABSTRACT FROM AUTHOR]- Published
- 2020
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13. Understanding motivation to implement smoking bans among mothers with a hospitalized infant.
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Stotts, Angela L., Klawans, Michelle R., Northrup, Thomas F., Villarreal, Yolanda, and Hovell, Melbourne F.
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SMOKING policy , *PASSIVE smoking , *INFANT health , *MOTIVATION (Psychology) , *SELF-efficacy , *MOTHERS , *SUBSTANCE abuse - Abstract
Objective: Secondhand smoke exposure (SHSe) poses risks to hospitalized children upon discharge and no uniformly effective interventions have been identified. Understanding change-related processes and social-contextual factors related to motivation for implementing home and car smoking bans may inform interventions to reduce infant SHSe among mothers with a hospitalized infant.Methods: In this cross-sectional, secondary analysis, mothers of neonatal ICU infants who reported smoking or living with a smoker (N=205) were assigned to stages of change (pre-contemplation, contemplation, preparation, or action) based on behaviors and intentions for establishing smoking bans in their homes and cars. Processes of change (POC) for SHSe reduction practices, self-efficacy, depressive symptoms, generalized anxiety, and social support for not smoking in the home were examined across all four stages.Results: The majority of mothers were in the action stage for having a home smoking ban in place (55%); only 35% of participants were in action for a car smoking ban. POC use differed across the stages of change for having a home ban (p=0.004) and car ban (p=0.02), with earlier stages using fewer overall and relatively fewer cognitive/affective processes. Earlier stage women also reported lower self-efficacy to change, less familial and partner support for in-home smoking bans, and more depressive symptoms.Conclusions: Novel intervention targets were identified, including cognitive/affective change processes, mental health, and familial/social contingencies for implementing SHSe protective practices. Creative ways in which to affect change at the individual and household level are needed in order to fully address the complexity of child SHSe. [ABSTRACT FROM AUTHOR]- Published
- 2016
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14. Identifying and responding to trial implementation challenges during multisite clinical trials.
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Greer, Tracy L., Walker, Robrina, Rethorst, Chad D., Northrup, Thomas F., Warden, Diane, Horigian, Viviana E., Silverstein, Meredith, Shores-Wilson, Kathy, Stotts, Angela L., and Trivedi, Madhukar H.
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DRUG abuse treatment , *CLINICAL trials , *RESEARCH implementation , *DRUG abuse - Abstract
The National Drug Abuse Treatment Clinical Trials Network (CTN) was initiated by the National Institute on Drug Abuse (NIDA) in 2000 with the aim of improving substance use treatment and reducing the time between the discovery of effective treatments and their implementation into clinical practice. While initial trials were conducted almost exclusively in specialty addiction treatment settings, the CTN began evolving strategically in 2010 to conduct research in general medical settings, including healthcare systems, primary care settings, emergency departments, and pharmacies, to broaden impact. The advantages of a research network like the CTN is not only the collective content expertise that investigators contribute to the network, but the collective experience gained by conducting studies in the network and then applying those lessons to future studies. To summarize trial implementation challenges encountered, and the process by which solutions were identified and implemented, within one of the last early-phase CTN Stage II behavioral intervention studies conducted in a specialty addiction treatment setting. We describe the implementation of the CTN-0037 STimulant Reduction Intervention using Dosed Exercise (STRIDE) trial. Issues encountered during study implementation are categorized into four major areas, described in terms useful to future study teams: 1) study team infrastructure challenges, 2) participant- and site- level challenges, 3) intervention-related challenges, and 4) longitudinal study design challenges. Potential consequences of identified problems and the solutions developed to manage these problems are discussed within the context of these four areas. We propose how to extend these implementation lessons and apply them in other healthcare settings to expand the CTN. Effective study management allows for flexible, collaborative solutions to expected and unexpected obstacles to study success. Implementation strategies derived from the first 15 to 20 years of CTN studies are a result of working with providers and participants, and the ongoing collaboration among CTN investigators and network staff. Timely identification and response to problems during study implementation are critical to the success of a trial, regardless of its design. We believe a collaborative approach to identifying and responding to study implementation challenges will increase the likelihood of successful adoption of relevant, efficacious interventions. As the CTN continues to expand, the wealth of successful trial implementation strategies developed during the first 20 years of the CTN need to be applied and adapted to studies in broader network settings, and considered in conjunction with more formalized implementation science processes that are currently available. • Effective trial management requires • collaborative and ongoing problem-solving • CTN trials have expanded from specialty settings to larger general medical settings • Historical implementation lessons from earlier CTN trials can meaningfully inform future trials • We describe CTN0037's infrastructure, participant- and site- level, intervention, and longitudinal design challenges • Historical information coupled with structured monitoring can increase trial impact [ABSTRACT FROM AUTHOR]
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- 2020
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15. Naltrexone plus bupropion reduces cigarette smoking in individuals with methamphetamine use disorder: A secondary analysis from the CTN ADAPT-2 trial.
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Schmitz, Joy M., Stotts, Angela L., Yoon, Jin H., Northrup, Thomas F., Villarreal, Yolanda R., Yammine, Luba, Weaver, Michael F., Carmody, Thomas, Shoptaw, Steven, and Trivedi, Madhukar H.
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SMOKING prevention , *NALTREXONE , *SUBSTANCE abuse , *SMOKING cessation , *COMBINATION drug therapy , *INJECTIONS , *ORAL drug administration , *SELF-evaluation , *METHAMPHETAMINE , *TREATMENT effectiveness , *BUPROPION , *CONTROLLED release preparations , *DESCRIPTIVE statistics , *SECONDARY analysis , *EVALUATION - Abstract
Methamphetamine (MA) use is marked by high rates of comorbid tobacco smoking, which is associated with more severe drug use and worse clinical outcomes compared to single use of either drug. Research has shown the combination of naltrexone plus oral bupropion (NTX-BUP) improves smoking cessation outcomes in non-MA-using populations. In the Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) study, NTX-BUP successfully reduced MA use. Our aim in this secondary data analysis was to examine changes in cigarette smoking among the subgroup of participants reporting comorbid tobacco use in the ADAPT-2 trial. The multi-site ADAPT-2 study used a randomized, double blind, sequential parallel comparison design to evaluate treatment with extended-release injectable NTX (380 mg every 3 weeks) combined with once-daily oral extended-release BUP (450 mg/day) vs matching injectable and oral placebo in outpatients with moderate or severe MA use disorder. The study assessed smoking outcomes, based on self-reported timeline followback (TLFB) data, twice/week for 13 weeks. Of the 403 participants in the ADAPT-2 trial, 290 reported being current cigarette smokers (71.9 %). The study found significant differences (p 's < 0.0001) for each smoking outcome indicating greater change in the proportion of nonsmoking days, number of cigarettes smoked per week, and consecutive nonsmoking days, all favoring the group receiving NTX-BUP versus placebo. NTX-BUP was associated with significant reductions in self-reported cigarette smoking in the context of concurrent treatment for MA use disorder. These off-target medication effects warrant prospective investigation using biochemically confirmed measures of smoking abstinence. The development of NTX-BUP as a co-addiction treatment strategy has a potential for high public health impact. • The majority of individuals seeking treatment for methamphetamine use disorder were current cigarette smokers. • The medication combination of injectable naltrexone plus oral bupropion was effective in reducing cigarette smoking. • These medication effects warrant prospective investigation using biochemically-confirmed measures of smoking abstinence. • The development of NTX-BUP as a co-addiction treatment strategy has a potential for high public health impact. [ABSTRACT FROM AUTHOR]
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- 2023
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16. A Stage I pilot study of acceptance and commitment therapy for methadone detoxification
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Stotts, Angela L., Green, Charles, Masuda, Akihiko, Grabowski, John, Wilson, Kelly, Northrup, Thomas F., Moeller, F. Gerard, and Schmitz, Joy M.
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PILOT projects , *METHADONE hydrochloride , *DETOXIFICATION (Substance abuse treatment) , *OPIOID abuse , *ACCEPTANCE & commitment therapy , *DRUG abuse , *BEHAVIOR therapy , *CLINICAL medicine - Abstract
Abstract: Background: While agonist replacement therapies are effective for managing opioid dependence, community treatment programs are increasingly choosing detoxification. Unfortunately, success rates for opioid detoxification are very low, in part, due to physical and psychological symptoms associated with opioid withdrawal. Few behavior therapies specifically address the distressing experiences specific to opioid withdrawal. A novel behavioral treatment, acceptance and commitment therapy (ACT), works from the premise that the avoidance of unpleasant private experiences (thoughts, feelings, bodily sensations) is ubiquitous yet may be pathogenic, resulting in treatment drop-out and further drug use. Methods: This Stage I pilot study developed and tested an ACT-based opioid detoxification behavioral therapy. Opioid dependent patients (N =56) who were attending a licensed methadone clinic were randomized to receive either 24 individual therapy sessions of ACT or drug counseling (DC) in the context of a 6-month methadone dose reduction program. Results: While no difference was found on opioid use during treatment, 37% of participants in the ACT condition were successfully detoxified at the end of treatment compared to 19% of those who received DC. Fear of detoxification was also reduced across time in the ACT condition relative to DC. Conclusion: This first study of ACT to assist opioid detoxification indicates promise. Research is needed to refine specific treatment strategies for this population to further strengthen effects. [Copyright &y& Elsevier]
- Published
- 2012
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