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There are several retrospective studies comparing rotational atherectomy (RA) and orbital atherectomy (OA), but all percutaneous coronary interventions (PCIs) in those studies were not performed under intracoronary imaging guidance. This study sought to compare the efficacy and safety of optical coherence tomography (OCT)-guided PCI with RA vs OA. The DIRO (To directly compare RA and OA for calcified lesions, a prospective randomized trial) trial was conducted. We enrolled patients with de novo calcified lesions (arc >180°) assessed by OCT or angiographically moderate or severe calcifications if the OCT catheter could not cross the lesion before any intervention. Eligible patients were randomly 1:1 allocated to lesion preparation with RA vs OA. Stent expansion was defined as the minimum stent area divided by the distal reference area multiplied by 100. Tissue modification was assessed using preatherectomy and postatherectomy OCT images. Procedural outcomes including periprocedural myocardial infarctions were evaluated. Furthermore, clinical events and vascular healing evaluated by OCT at 8 months postprocedure were assessed. The stent expansion was significantly greater in the RA group vs the OA group (99.5% vs 90.6%; P = 0.02). The maximum atherectomy area was significantly larger in the RA group than in the OA group (1.34 [IQR: 1.02-1.89] mm2 vs 0.83 [IQR: 0.59-1.11] mm2; P = 0.004). The procedural outcomes and clinical events at 8 months did not differ between the groups. The vascular healing was sufficient in both groups. The prospective randomized DIRO trial revealed that RA could produce a more favorable tissue modification, which may lead to a larger stent expansion than OA in heavily calcified lesions. [Display omitted] [ABSTRACT FROM AUTHOR]

The VNTR polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene has been shown associated with ulcerative colitis (UC) in some populations. This study aimed to assess the relationship between the IL-1RA polymorphism and UC in a Japanese population. Genotyping was carried out with polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method for 468 DNA specimens from 239 healthy volunteers and 229 patients with UC. Genotype distribution was compared between cases and controls, and association of patients’ genotype with clinical parameters was evaluated. No significant difference of genotype distribution was found between UC patients and healthy controls. However, when the relation of the carriage rate of allele 2 with clinical parameters was evaluated by Fisher’s exact test, it was found that the allele 2 carriage rate was higher in patients with lower ages at diagnosis (<30) than those with higher ages (≥30) (odds ratio (OR), 5.049; 95% confidence interval (CI), 1.667–15.288; P=0.0020). In addition, it tended to be higher in patients with pancolitis type than those with other types restricted to the distal or left-sided colon (OR, 3.005; 95% CI, 1.186–7.616; P=0.0256). These data suggest that the IL-1RA polymorphism is associated with UC with younger age at diagnosis. [Copyright &y& Elsevier]

Abstract: The collision processes of highly charged ions with electrons have been studied with an electron beam ion trap. Resonant inner-shell processes such as dielectronic recombination and resonant excitation double autoionization were investigated by observing the number ratio of extracted ions with adjacent charge states. [Copyright &y& Elsevier]