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To assess the prevalence of pelvic pain worsened by orgasm in patients with endometriosis and its associated clinical features, focusing on those related to pelvic floor myalgia, central sensitization, and surgical findings. Prospectively collected data were analysed. Data were collected at three timepoints: pre-appointment patient questionnaire, initial appointment, and surgery. Surgery was done by gynecologists specializing in endometriosis. Tertiary referral centre for pelvic pain and endometriosis. Participants included were aged 18 to 50, pre-menopausal, diagnosed with endometriosis via specified criteria, and underwent surgery at our centre. A total of 358 participants referred to our centre between January 2018 and December 2019 completed the study. The median follow-up (duration between pre-appointment questionnaire and surgery) was 6 months, range 0-28 months. Participants who reported that orgasm worsened their pelvic or lower abdominal pain were compared to those who did not. Among 358 participants, 14% (n=49) reported pelvic pain worsened by orgasm. Pain with orgasm was significantly associated with pelvic floor myalgia (p = 0.01), higher scores on the Central Sensitization Inventory (p < 0.001), Patient Health Quality-9 (p < 0.001), and Generalized Anxiety Disorder-7 (p = 0.002). For surgical findings, there was no difference between the two groups for revised American Society for Reproductive Medicine scores (p=0.07). There was a trend towards ovarian endometriosis more commonly seen in participants without orgasm-associated pain (p=0.049). However, the prevalence of superficial peritoneal endometriosis, deep infiltrating endometriosis, and cul-de-sac obliteration were similar between the two groups. Pelvic pain worsened by orgasm in people with endometriosis may be associated with concurrent pelvic floor myalgia and central sensitization. Interventions targeting these factors may alleviate the symptom. There were no associations with more anatomically severe endometriosis found at surgery. Further research is needed to identify effective treatments. [ABSTRACT FROM AUTHOR]

EFI is a robust tool to predict pregnancy rate in endometriosis patients who attempt non-in vitro fertilization conception. However, EFI calculation requires laparoscopy. Sliding sign is a newly established technique that can predict Pouch of Douglas (POD) obliteration with a high degree of accuracy. The objective of this study is to investigate the relationship between sliding sign and the EFI, and to explore the practicality of using sliding sign to predict EFI score less than seven. Observational study from a prospective registry (Endometriosis Pelvic Pain Interdisciplinary Cohort (EPPIC), ClinicalTrials.gov#NCT02911090). Analyzed data was captured from December 2013 to June 2017. Tertiary referral center at British Columbia Women's Hospital. Eighty-six women who are less than 40 years old. Dynamic ultrasonography for the sliding sign testing and EFI calculation during laparoscopic surgery. Patients with a negative sliding sign(N=26,Group I) were older, had stage IV endometriosis, and a lower median EFI score than patients who had a positive sliding sign (N=60,Group II).Patients in group I had significantly lower surgical factor scores, Regarding the EFI historical factors, group I participants had a longer duration of infertility with no significant difference in parity or age compared to group II. Logistic regression showed that an EFI score < 7 can be predicted with a high sensitivity of 87.9% and specificity of 81.1% with a negative sliding sign and EFI historical factors score. The area under the curve (AUC) was 0.93 (95% CI 0.85–0.99). The sliding sign could be a potential alternative to the EFI surgical factors, and it could be used in combination with EFI historical factors to predict an EFI score < 7 for patients who are not scheduled for immediate surgery. [ABSTRACT FROM AUTHOR]

The band structure of Ca 3 Ga 2 Ge 3 О 12 with the garnet structure has been determined for the first time by X-ray emission and photoelectron spectroscopy. It has been established that the bottom of the valence band is formed by Ge d states, which are not dominant in the chemical bonding. Strong hybridization of oxygen 2 s states with 4 p states of Ga and Ge revealed by the presence of an extra structure in the X-ray emission spectra has been found. The middle of the valence band has been demonstrated to be occupied by d states of Ga, while Ga and Ge 4 р states with a considerable admixture of oxygen 2 p states form the top of the valence band. [ABSTRACT FROM AUTHOR]

X-ray absorption spectrum at the Yb L 3 edge and X-ray emission spectra of Ni and P at the K and L 2,3 edges have been studied experimentally and theoretically in the mixed valent compound YbNi 2 P 2 with ThCr 2 Si 2 type crystal structure. The electronic structure of YbNi 2 P 2 is investigated using the fully relativistic Dirac linear muffin-tin orbital (LMTO) band-structure method. The effect of the spin–orbit (SO) interaction and Coulomb repulsion U on the electronic structure of YbNi 2 P 2 is examined in the frame of the LSDA + SO + U method. The core-hole effect in the final states as well as the effect of the electric quadrupole E 2 transitions have been investigated. A good agreement between the theory and the experiment was found. Both the trivalent and the divalent Yb ions in YbNi 2 P 2 are reflected in the experimentally measured Yb L 3 X-ray absorption spectrum simultaneously. We found that the best agreement between the experimental spectrum and sum of the theoretically calculated Yb 2+ and Yb 3+ spectra is achieved with 73% ytterbium ions in 2+ state and 27% ions in 3+ state. [ABSTRACT FROM AUTHOR]