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Your search keyword '"Niedbala H"' showing total 3 results
Start Over Author "Niedbala H" Publisher elsevier b.v.
3 results on '"Niedbala H"'

1. Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

Author

Podeszwa, B., Niedbala, H., Polanski, J., Musiol, R., Tabak, D., Finster, J., Serafin, K., Milczarek, M., Wietrzyk, J., Boryczka, S., Mol, W., Jampilek, J., Dohnal, J., Kalinowski, D.S., and Richardson, D.R.

Subjects
*CELL culture, *CELL lines, *CANCER cells, *QUINOLINE
Abstract

Abstract: The structure–activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity. [Copyright &y& Elsevier]

Published
2007
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