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Start Over Author "Nesi, G." Publisher elsevier b.v.
31 results on '"Nesi, G."'

2. hERG1 and CA IX expression are associated with disease recurrence in surgically resected clear cell renal carcinoma.

Author

Lastraioli, E., Pillozzi, S., Mari, A., Tellini, R., Duranti, C., Baldazzi, V., Venturini, S., Minervini, A., Lapini, A., Nesi, G., Carini, M., and Arcangeli, A.

Subjects
RENAL cell carcinoma, CARNOSIC acid, PLATELET-derived growth factor, DISEASE relapse, GLUCOSE transporters, CARBONIC anhydrase
Abstract

In search of novel prognostic biomarkers for clear cell renal carcinoma (ccRCC), we analysed the expression of several proteins related to angiogenesis and hypoxia. A monocentric study on 30 consecutive surgical samples from surgically-treated ccRCC patients with a 10-year follow up was performed. The following proteins were analysed by immunohistochemistry: Vascular Endothelial Growth Factor- A (VEGF-A), Platelet-Derived Growth Factor β Receptor (PDGFRβ), VEGF-receptor 1 (Flt1), VEGF-receptor 2 (KDR), Glucose Transporter 1 (GLUT1), Carbonic anhydrase IX (CA-IX) and the hERG1 potassium channel. Data were analysed in conjunction with the clinico-pathological characteristics of the patients and follow up. All the proteins were expressed in the samples, with statistically significant associations of VEGF-A with PDGFRβ and Flt1 and hERG1 with CA IX. Notably, hERG1 and CAIX co-immunoprecipitated in primary ccRCC samples and survival analysis showed that the positivity for hERG1 and CA IX had a negative impact on Recurrence Free Survival (RFS) at the univariate analysis. At the multivariate analysis only hERG1 maintained its statistically significant negative impact. Conclusions: hERG1 expression can be exploited to predict recurrence in surgically-treated ccRCC patients. hERG1 channels form a multiprotein complex with the pH regulator CA IX in primary ccRCC samples their potential use as therapeutic target might be suggested. [ABSTRACT FROM AUTHOR]

Published
2020
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4. Gender and cystectomy for bladder cancer: A high-volume tertiary urologic care center experience.

Author

Mariotti, A., Spatafora, P., Sessa, F., Saieva, C., Galli, I.C., Roviello, G., Doni, L., Zaccaro, C., Bisegna, C., Conte, F.L., Mariottini, R., Marzocco, A., Masieri, L., Vignolini, G., Minervini, A., Serni, S., Carini, M., Nesi, G., and Villari, D.

Subjects
BLADDER cancer, SEX factors in disease, PATIENTS, MYOCARDIAL infarction, CYSTECTOMY, URINARY diversion
Abstract

Differences have often been reported in the outcomes of bladder cancer (BC) patients according to gender. This study aims to provide data on patients undergoing radical cystectomy (RC) in a high-volume tertiary urologic center and to assess whether gender discrepancies do exist in terms of surgical options and clinical outcomes. Consecutive BC patients treated between 2016 and 2020 at a single center (Careggi University Hospital, Florence, Italy) were included in the study. The impact of gender on disease stage at diagnosis, overall survival (OS), and type of surgery was analyzed. The study series comprised 447 patients (85 females and 362 males). At a median follow-up of 28.3 months (IQR: 33.5), OS was 52.6% and cancer-specific survival was 67.6%. Significant differences in OS emerged for age, acute myocardial infarction (AMI), Charlson Comorbidity Index (CCI), pT, and pN. OS rates were higher in patients undergoing robot-assisted surgery and in those receiving open orthotopic neobladder (ONB) (p = 0.0001). No statistically significant differences were found between male and female patients regarding surgical offer in any age group, surgical time, early postoperative complications, pathologic stage, and OS. After adjustment for pathologic tumor stage and treatment modalities, female and male patients showed similar oncologic outcomes. Further studies should be undertaken to evaluate functional results in women subjected to RC. [ABSTRACT FROM AUTHOR]

Published
2023
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16. OC.11.1 PROGRAMMED CELL DEATH LIGAND-1 (PD-L1) EXPRESSION IS COUPLED WITH MICROSATELLITE INSTABILITY IN NON-FAMILIAL SMALL BOWEL CARCINOMAS ASSOCIATED OR NOT WITH COELIAC DISEASE OR CROHN'S DISEASE: RESULTS FROM THE SMALL BOWEL CANCER ITALIAN...

Author

Vanoli, A., Giuffrida, P., Martino, M., Persichella, A., Viglio, A., Furlan, D., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabrò, A., Tonelli, F., Volta, U., and Santini, D.

Published
2018
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