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Your search keyword '"Navarrete, Jose A."' showing total 10 results
Start Over Author "Navarrete, Jose A." Publisher elsevier b.v.
10 results on '"Navarrete, Jose A."'

5. Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Author

Latorre, Jèssica, Ortega, Francisco J., Liñares-Pose, Laura, Moreno-Navarrete, José M., Lluch, Aina, Comas, Ferran, Oliveras-Cañellas, Núria, Ricart, Wifredo, Höring, Marcus, Zhou, You, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M., López, Miguel, and Fernández-Real, José M.

Published
2020
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8. Role of Mitochondrial Complex IV in Age-Dependent Obesity.

Author

Soro-Arnaiz, Ines, Li, Qilong Oscar Yang, Torres-Capelli, Mar, Meléndez-Rodríguez, Florinda, Veiga, Sónia, Veys, Koen, Sebastian, David, Elorza, Ainara, Tello, Daniel, Hernansanz-Agustín, Pablo, Cogliati, Sara, Moreno-Navarrete, Jose Maria, Balsa, Eduardo, Fuertes, Esther, Romanos, Eduardo, Martínez-Ruiz, Antonio, Enriquez, Jose Antonio, Fernandez-Real, Jose Manuel, Zorzano, Antonio, and De Bock, Katrien

Abstract

Summary Aging is associated with progressive white adipose tissue (WAT) enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV) activity and assembly are already repressed in white adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV components such as COX5B. At the molecular level, HIF1A binds to the Cox5b proximal promoter and represses its expression. Silencing of Cox5b decreased fatty acid oxidation and promoted intracellular lipid accumulation. Moreover, local in vivo Cox5b silencing in WAT of young mice increased the size of adipocytes, whereas restoration of COX5B expression in aging mice counteracted adipocyte enlargement. An age-dependent reduction in COX5B gene expression was also found in human visceral adipose tissue. Collectively, our findings establish a pivotal role for CIV dysfunction in progressive white adipocyte enlargement during aging, which can be restored to alleviate age-dependent WAT expansion. [ABSTRACT FROM AUTHOR]

Published
2016
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10. THE CONTROL OF DIABETES: HBA1C

Author

De La Torre Fernandez, Jose, Peña, Francisco Miguel Rodriguez, Bueno, Gema Soriano, Martin, Francisca Cazalla, De La Torre Navarrete, Jose, Moreno, Soledad Sanchez-Montes, and Luque, Federico Navajas

Published
2011
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