11 results on '"Morace, Roberta"'
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2. Alpha, beta and gamma electrocorticographic rhythms in somatosensory, motor, premotor and prefrontal cortical areas differ in movement execution and observation in humans
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Babiloni, Claudio, Del Percio, Claudio, Vecchio, Fabrizio, Sebastiano, Fabio, Di Gennaro, Giancarlo, Quarato, Pier P., Morace, Roberta, Pavone, Luigi, Soricelli, Andrea, Noce, Giuseppe, Esposito, Vincenzo, Rossini, Paolo Maria, Gallese, Vittorio, and Mirabella, Giovanni
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- 2016
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3. Multilevel Postoperative Cervical Epidural Hematoma: Complete Removal Through Catheter Drainage of the Unexposed Blood Collection.
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Morace, Roberta, di Russo, Paolo, Gorgoglione, Nicola, Bua, Antonella, Vangelista, Tommaso, Chiarella, Vito, De Angelis, Michelangelo, and Esposito, Vincenzo
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DISCECTOMY , *EPIDURAL hematoma , *EPIDURAL catheters , *BLOOD collection , *EPIDURAL space , *SPINAL surgery , *EPIDURAL abscess , *SURGICAL decompression , *CERVICAL spondylotic myelopathy - Abstract
Postoperative spinal epidural hematoma is a rare complication of anterior cervical discectomy and fusion. This condition may rapidly produce severe neurologic deficits, often requiring a prompt surgical decompression. A multilevel extension of the epidural bleeding has been rarely described after anterior cervical procedures. In such cases, the choice of the most suitable surgical approach may be challenging. Herein, we describe an effective surgical decompression of a C2-T1 ventral epidural hematoma following anterior cervical discectomy and fusion at the C5-C6 level. By reopening the previous approach, the C5-C6 intersomatic cage was removed and the surgical field inspected for bleeding. After removal of the spinal epidural hematoma at this level, a lumbar external drainage catheter was inserted into the epidural space to perform multiple irrigations with saline solution until the washing fluid was clear. Immediate postoperative cervical computed tomography and magnetic resonance imaging revealed gross total removal of the epidural hematoma and complete decompression of the spinal cord all along the affected tract. Early postoperative neurologic examination revealed mild lower extremity weakness that fully recovered within hours. Although rare, multilevel epidural hematoma following anterior cervical decompression represents a serious complication. The revision of the previous anterior cervical approach may be considered the first treatment option, allowing to control the primary bleeding site. Catheter irrigation of the epidural space with saline solution may be a useful technique for removal of unexposed residual blood collection, avoiding the need for posterior laminectomy or other unnecessary bone demolition. [ABSTRACT FROM AUTHOR]
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- 2021
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4. Temporal pole abnormalities detected by 3 T MRI in temporal lobe epilepsy due to hippocampal sclerosis: No influence on seizure outcome after surgery.
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Casciato, Sara, Picardi, Angelo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio Nicolo’, Morace, Roberta, Esposito, Vincenzo, Di Gennaro, Giancarlo, D'Aniello, Alfredo, and Meldolesi, Giulio Nicolo'
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Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) detected by using 3 Tesla MRI in the preoperative workup in patients with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) who underwent surgery.Methods: We studied 78 consecutive patients with TLE-HS who underwent surgery and were followed up for at least 2 years. Based on findings of pre-surgical 3 Tesla MRI, patients were subdivided in subgroups according to the presence of TB or TA. Subgroups were compared on demographic, clinical, neuropsychological data and seizure outcome.Results: TB was found in 39 (50%) patients, while TA was found in 32 (41%) patients, always ipsilateral to HS, with a considerable degree of overlap (69%) between TB and TA (p=0.01). Patients with temporopolar abnormalities did not significantly differ from those without TB or TA with regard to sex, age, age of epilepsy onset, duration of epilepsy, history of febrile convulsions or birth complications, side of surgery, seizure frequency at surgery, presence of GTCSs, and, in particular, seizure outcome. On the other hand, TB patients show a less frequent family history of epilepsy (p<.05) while age at epilepsy onset showed a trend to be lower in the TB group (p=.09). Patients with temporopolar atrophy did not significantly differ from those without TA on any variable, except for age at epilepsy onset, which was significantly lower for the TA group (p<.05). History of birth complications and longer duration of epilepsy also showed a trend to be associated with TA (p=.08). Multivariate analysis corroborated the association between temporopolar abnormalities and absence of family history of epilepsy and history of birth complications.Conclusions: High-field 3 T MRI in the preoperative workup for epilepsy surgery confirms that temporopolar abnormalities are frequent findings in TLE-HS patients and may be helpful to lateralize the epileptogenic zone. Their presence did not influence seizure outcome. [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Sedation with α2 Agonist Dexmedetomidine During Unilateral Subthalamic Nucleus Deep Brain Stimulation: A Preliminary Report.
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Morace, Roberta, De Angelis, Michelangelo, Aglialoro, Emiliano, Maucione, Gianni, Cavallo, LuigiMaria, Solari, Domenico, Modugno, Nicola, Santilli, Marco, Esposito, Vincenzo, and Aloj, Fulvio
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DEXMEDETOMIDINE , *DEEP brain stimulation , *ANESTHESIA , *SUBTHALAMIC nucleus , *PARKINSON'S disease , *MOTOR ability , *SAFETY - Abstract
Objective The α 2 agonist dexmedetomidine (DEX) is an anesthetic agent that can provide sedation and analgesia without respiratory depression or changes in neuronal activity during microrecordings. The aim of our study was to confirm the efficacy and safety of anesthesia with DEX for unilateral deep brain stimulation of the subthalamic nucleus (STN) in patients with Parkinson disease. Methods In 2013 and 2014, a series of 11 consecutive patients received continuous low-dose DEX infusion during unilateral deep brain stimulation of the STN. Intraoperative microrecordings, stimulation results, and patient reaction times in executing verbal and motor tasks were retrospectively analyzed. Functional outcomes were evaluated by comparing preoperative and 1-year postoperative Unified Parkinson's Disease Rating Scale Part III scores. Results Typical activity of the STN was recorded in all patients, and the delay in the execution of both motor and verbal tasks was ≤2 seconds. No hemorrhagic complications occurred, and no postoperative side effects were observed. The mean percentage of Unified Parkinson's Disease Rating Scale Part III improvement at last follow-up was 39.01% (range, 23.70%–55.60%). The mean percentage of levodopa equivalent dose reduction was 45.86% (range, 21.50%–65.70%). Conclusions The results of our study confirm that the use of DEX in managing patients with Parkinson disease during unilateral deep brain stimulation of the STN is safe and effective and can be considered a promising option for sedation during this type of procedure. [ABSTRACT FROM AUTHOR]
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- 2016
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6. Temporal pole abnormalities in temporal lobe epilepsy with hippocampal sclerosis: Clinical significance and seizure outcome after surgery.
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Di Gennaro, Giancarlo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Casciato, Sara, Morace, Roberta, Esposito, Vincenzo, Picardi, Angelo, and D'Aniello, Alfredo
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) with a long post-surgical follow-up.Methods: We studied 60 consecutive patients with TLE-HS and 1.5 preoperative MRI scans who underwent surgery and were followed up for at least 5 years (mean follow-up 7.3 years). Based on findings of pre-surgical MRI, patients were classified according to the presence of TB or TA. Groups were compared on demographic, clinical, neuropsychological data, and seizure outcome.Results: TB was found in 37 (62%) patients, while TA was found in 35 (58%) patients, always ipsilateral to HS, with a high degree of overlap (83%) between TB and TA (p<0.001). Patients with TB did not differ from those without TB with regard to history of febrile convulsions, GTCSs, age of epilepsy onset, side of surgery, seizure frequency, seizure outcome, and neuropsychological outcome. On the other hand, they were significantly older, had a longer duration of epilepsy, and displayed lower preoperative scores on several neuropsychological tests. Similar findings were observed for TA. Multivariate analysis corroborated the association between temporopolar abnormalities and age at onset, age at surgery (for TB only), and lower preoperative scores on some neuropsychological tests.Conclusions: Temporopolar abnormalities are frequent in patients with TLE-HS. Our data support the hypothesis that TB and TA are caused by seizure-related damages. These abnormalities did not influence seizure outcome, even after a long-term post-surgical follow-up. [ABSTRACT FROM AUTHOR]- Published
- 2015
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7. Intracranial Capillary Hemangioma: A Description of Four Cases
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Morace, Roberta, Marongiu, Alessandra, Vangelista, Tommaso, Galasso, Vittorio, Colonnese, Claudio, Giangaspero, Felice, Innocenzi, Gualtiero, Esposito, Vincenzo, and Cantore, Giampaolo
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HEMANGIOMAS , *TUMORS in children , *SOFT tissue tumors , *CAVERNOUS sinus , *HEMORRHAGIC diseases , *RADIOTHERAPY , *TOMOGRAPHY , *CANCER relapse , *PREVENTION - Abstract
Objective: Capillary hemangiomas are benign vascular lesions involving the skin and soft tissues that commonly occur at birth or an early age. Intracranial capillary hemangiomas are extremely rare; only 14 cases have been reported the literature. Case Description: We describe four patients with capillary hemangiomas. In two of these patients the lesions arose from the cavernous sinus. In the third patient, a large capillary hemangioma arising from the middle cranial fossa extended into the infratemporal fossa. The fourth patient had a left hemorrhagic temporoparietal capillary hemangioma. Results: The first two patients underwent a partial resection, followed by radiotherapy. Local tumor control was achieved in both cases, as shown by the follow-up magnetic resonance imaging. In the third patient the lesion was subtotally removed after embolization. Radiotherapy, performed one year after surgery because of recurrence, allowed tumor control. In the fourth patient surgical removal was total and no adjuvant radiotherapy was required after surgery; follow-up magnetic resonance imaging did not show any recurrence at the one-year follow-up. Conclusion: Surgery is an option for symptomatic intracranial capillary hemangiomas. However, because partial removal is associated with a high recurrence rate, capillary hemangiomas that cannot be removed radically should be treated with radiotherapy, which offers the possibility of controlling lesion size and preventing tumor recurrence. [Copyright &y& Elsevier]
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- 2012
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8. The Interhemispheric Transgenual Approach for Microsurgical Removal of Third Ventricle Colloid Cysts. Technical Note.
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Esposito, Vincenzo, di Russo, Paolo, Del Maestro, Mattia, Ciavarro, Marco, Vangelista, Tommaso, De Angelis, Michelangelo, Fava, Arianna, and Morace, Roberta
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COLLOIDS , *INTRACRANIAL tumors , *NEUROPHYSIOLOGIC monitoring , *SURGICAL complications , *MAGNETIC resonance imaging , *POSTOPERATIVE period , *URINARY diversion - Abstract
Colloid cysts of the third ventricle are rare benign lesions, which amount to approximately 1% of all intracranial tumors. Because these lesions grow predominantly in the anterior aspect of the third ventricle, they may cause the occlusion of the foramina of Monro, generating obstructive hydrocephalus. Surgery is mandatory in cases of large cysts and/or in symptomatic patients. Among the different surgical strategies described in colloid cysts surgery, the microsurgical transcallosal approach still constitutes the procedure of choice in many centers. In this study, we describe a modified microsurgical transcallosal approach, the interhemispheric transgenual approach, in a series of 13 consecutive patients operated on for colloid cysts of the third ventricle. All the procedures were performed by the senior author (V.E.) at Neuromed Institute of Pozzilli (Is, Italy). The operative procedure is described in its various steps, illustrating the differences and potential advantages compared with the traditional microsurgical transcallosal approach. No surgical complications or new-onset neurologic deficits were observed in the postoperative period. The postoperative magnetic resonance imaging confirmed in all cases complete lesion removal without any sign of parenchymal damage. No lesion recurrence or need for permanent cerebrospinal fluid diversion was detected in the patients of this series during the follow-up period. In our experience, the interhemispheric transgenual approach has been effective in providing complete colloid cyst removal with minimal risk of vascular and parenchymal damage. Further studies are required to confirm its efficacy in improving the overall outcome of the microsurgical transcallosal approach. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Computed Tomography−Guided Posterolateral Transsacral Ala Approach to Presacral L5 Schwannoma: Technical Note.
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Pizzuti, Valentina, di Russo, Paolo, Esposito, Vincenzo, and Morace, Roberta
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NEUROPHYSIOLOGIC monitoring , *BENIGN tumors , *SCHWANNOMAS , *MAGNETIC resonance imaging , *THERAPEUTICS , *COMPUTED tomography - Abstract
Presacral schwannomas are rare benign tumors that may reach large size before becoming symptomatic. Total surgical removal has been considered the best treatment option. Tumors arising from the presacral area are commonly managed through anterior approaches, whereas posterior approaches are used for pure intrasacral tumors or large lesions with both intrasacral and presacral extension, alone or in combination with anterior approaches. We describe a quick and minimally invasive navigation-guided posterolateral approach to a right presacral L5 schwannoma. The lesion was microsurgically removed through high-speed drilling of the upper portion of the right sacral ala, under intraoperative neurophysiologic monitoring. The postoperative course was unremarkable, and the patient experienced improvement in his sensory disturbance. Postoperative magnetic resonance imaging and computed tomography scan showed the complete excision of the lesion and the removal of the upper sacral ala with preservation of the right L5-S1 articular complex. The histologic examination confirmed a schwannoma (World Health Organization grade I). The posterolateral transsacral ala approach may represent a minimally invasive option in the surgical management of presacral well-circumscribed benign tumors. Spinal navigation could be properly used to facilitate lesion exposure and to minimize the bone removal. The intraoperative neurophysiologic monitoring is an essential tool for the preservation of the lumbosacral nerve roots. [ABSTRACT FROM AUTHOR]
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- 2019
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10. Comparative effectiveness of multi-fraction stereotactic radiosurgery for surgically resected or intact large brain metastases from non-small-cell lung cancer (NSCLC).
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Minniti, Giuseppe, Scaringi, Claudia, Lanzetta, Gaetano, Anzellini, Dimitri, Bianciardi, Federico, Tolu, Barbara, Morace, Roberta, Romano, Andrea, Osti, Mattia, Gentile, PierCarlo, and Paolini, Sergio
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STEREOTACTIC radiosurgery , *NON-small-cell lung carcinoma , *BRAIN metastasis , *MENINGEAL cancer , *THERAPEUTICS , *SURGICAL excision - Abstract
• Postoperative SRS is usually recommended for resected brain metastases. • 3 x 9 Gy demonstrates activity in both intact and resected large NSCLC metastases. • Local control is comparable between resected and intact large brain metastases. • A worse safety profile can be expected after surgery and postoperative SRS (3 x 9 Gy). Purpose: to investigate clinical outcomes in patients with large brain metastases from non-small-cell lung cancer (NSCLC) who received surgical resection and postoperative stereotactic radiosurgery or SRS alone. Patients and Methods: Two hundred and twenty-two patients with 241 large brain metastases (2–4 cm in size) who received surgery and multi-fraction SRS (mfSRS) to the resection cavity or mfSRS alone were analyzed. For all lesions the delivered dose was 3 x 9 Gy over three consecutive days. Primary endpoint of the study was local control (LC). Secondary endpoints included early improvement of neurological deficits, changes in performance status, treatment-related toxicity, radiation-induced brain necrosis (RN), distant brain failure (DBF), and overall survival (OS). Kaplan-Meier analysis and cumulative incidence function were used for comparing the probability of failure. Results: At a median follow-up of 13 months, median OS times and 1-year survival rates were comparable: 13.5 months and 59% for patients receiving surgery and postoperative mfSRS to the resection cavity and 15.2 months and 68% for those treated with mfSRS alone (p = 0.2). Median DBF did not differ significantly between groups (surgery and mfSRS,12 months; mfSRS,14 months). Eighteen patients receiving surgery and mfSRS and 17 patients treated with mfSRS alone recurred locally (p = 0.2); respective 6-month and 12-month LC rates were 87% and 83% and 96% and 91% (p = 0.15). The 1-year cumulative incidence rates of RN were 15% and 7% after postoperative mfSRS and mfSRS alone (p = 0.03), respectively. Conclusions: In conclusion, mfSRS is an effective treatment for patients with large brain metastases from NSCLC resulting in equivalent LC and lower RN and risk of leptomeningeal spread compared to surgery and mf-SRS to the resection cavity. Surgery is an effective treatment option for patients with large symptomatic brain metastases who require rapid relief of neurological symptoms caused by tumor mass effect. [ABSTRACT FROM AUTHOR]
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- 2019
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11. Unilateral deep brain stimulation of subthalamic nuclei does not affect reactive inhibition in Parkinson's patients.
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Mirabella, Giovanni, Giannini, Giorgio, Fragola, Michele, Santilli, Marco, Grillea, Giovanni, Morace, Roberta, and Modugno, Nicola
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PARKINSON'S disease patients , *DEEP brain stimulation , *SUBTHALAMIC nucleus , *MEDICAL statistics , *CLINICAL trials - Published
- 2016
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