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Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-γ-cyclodextrin metal−organic framework (POM–γCD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect in-situ released dopamine. The POM–γCD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM–γCD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker. [ABSTRACT FROM AUTHOR]

Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine analogues and their cytotoxic evaluation against three human cancer cell lines, that is, cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF-7), and prostate carcinoma (DU145). Analogues 12 , 14 and 15 were found to be the most potent against one or more cell lines with the IC 50 values in the range of 5–10 μM. The obtained results suggested that longer polyamine linker along with aromatic oxime substitution provided the most potent analogue compounds against cancer cell lines. [ABSTRACT FROM AUTHOR]

Abstract: A study of the stereo- and face selectivity of the cycloaddition reactions of several mono- and disubstituted alkenes with 4-hydroxymethyl-3,4,5,6-tetrahydropyridine 1-oxide has been carried out. The addition reactions have displayed a very high degree of face selectivity in the range 13-48:1. Use of dimethyl methylenemalonate as a protective group in nitrone cycloaddition reactions has been demonstrated. The invertomeric analysis revealed that the bicyclic cycloadducts remain predominantly as the cis-fused isomer, which leads to the formation of synthetically important second-generation cyclic aldonitrones via peracid oxidation. One interesting finding was that treatment of the cycloadducts with two equivalents of peracid afforded the cyclic N-hydroxy lactams, presumably via further oxidation of the aldonitrones. The piperidine ring has been elaborated by cycloaddition reaction of the second-generation nitrones with several alkenes, which in most cases gave the cycloadducts in a stereoselective manner. [Copyright &y& Elsevier]

• Synthesis and coating of trianglamine hydrochloride on IDE substrates. • Morphological characterization of trianglamine hydrochloride crystals. • Sensing of humidity. • Analysis of the sensitivity, selectivity, hysteresis, stability, and temperature coefficient of the humidity sensor. In this work, we present a highly sensitive and selective capacitive humidity sensor. Trianglamine hydrochloride is used as the sensing material, which is synthesized by a [3+3] cyclocondensation reaction between terpthaldehyde and 1R,2R-cyclohexanediamine followed by addition of hydrochloric acid and vapor diffusion of acetone. The crystalline trianglamine hydrochloride salts are dispersed in acetonitrile and then coated on interdigitated electrode substrates by drop casting. The sensor response is characterized for relative humidity (RH) ranging from 5% to 95%. The sensor has a nonlinear response, where the sensitivity increases with an increase in RH. The sensor demonstrates, on average, normalized sensitivities of 0.015 and 6.9 per percent of RH below and above 65% RH, respectively. In addition, the sensor is characterized for hysteresis, long-term stability, effect of temperature, and selectivity. The hysteresis of the sensor is a maximum of about 20% RH and is stable for over 25 days. Temperature analysis of the sensors shows that the sensitivity decreases with increase in temperature. The material is shown to be highly selective with respect to volatile organic compounds (VOCs) and toxic/corrosive gasses. Overall, trianglamine hydrochloride is a promising material for developing a highly sensitive and selective capacitive transduction-based humidity sensor. [ABSTRACT FROM AUTHOR]