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Preclinical micro-computed tomography (microCT) images are of utility for 3D morphological bone evaluation, which is of great interest in cancer detection and treatment development. This work introduces a compression strategy for microCTs that allocates specific substances in different Volumes of Interest (VoIs). The allocation procedure is conducted by the Hounsfield scale. The VoIs are coded independently and then grouped in a single DICOM-compliant file. The proposed method permits the use of different codecs, identifies and transmit data corresponding to a particular substance in the compressed domain without decoding the volume(s), and allows the computation of the 3D morphometry without needing to store or transmit the whole image. The proposed approach reduces the transmitted data in more than 90% when the 3D morphometry evaluation is performed in high density and low density bone. This work can be easily extended to other imaging modalities and applications that work with the Hounsfield scale. [ABSTRACT FROM AUTHOR]

This study evaluated the compressibility of multislice CT (MSCT) datasets and its dependence on (1) slice thickness and (2) the use of three-dimensional (3D) vs. 2D JPEG2000 compression methods. Five thoracic CT datasets were obtained using a 16-detector MSCT scanner with a collimation of 0.75 mm (120 kVp, 90 mAs) and reconstructed at five slice thicknesses from 0.75 to 10.0 mm. These datasets were irreversibly compressed using a standard 2D JPEG2000 encoder and a developmental 3D JPEG2000 algorithm based on Part 2 of the JPEG2000 standard. Compression ratios ranged from 4:1 to 64:1. Image distortion was computed utilizing peak signal-to-noise ratio (PSNR) and the Sarnoff JNDmetrix visual discrimination model. For 2D compression, the thinnest sections were substantially less compressible than thicker sections for the same level of image quality, particularly at higher compression ratios. Applying 3D compression yielded consistently higher image quality in most cases compared to 2D compression at the same ratios. The advantage of 3D compression increased for thinner slices and higher compression ratios. These results indicate that 3D JPEG2000 (Part 2) compression offers substantial advantages over the current 2D JPEG2000 standard, yielding better quantitative image quality at similar compression ratios or comparable image quality at higher compression ratios. [Copyright &y& Elsevier]