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Insulin-like growth factor 2 mRNA-binding proteins (IMPs, IGF2BPs) are RNA-binding proteins that regulate a variety of biological processes. In recent years, several studies have found that IGF2BPs play multiple roles in various biological processes, especially in cancer, and speculated on their mechanism of anticancer effect. In addition, targeting IGF2BPs or their downstream target gene has also received extensive attention as an effective treatment for different types of cancer. In this review, we summarized the recent progress on the role of IGF2BPs in cancers and their structural characteristics. We focused on describing the development of inhibitors targeting IGF2BPs and the prospects for further applications. [Display omitted] • The structural characteristics of IGF2BPs were analyzed in this review. • The biological functions and mechanisms of IGF2BPs in cancer were summarized. • Introduction of the latest progress and perspective of IGF2BPs inhibitors. [ABSTRACT FROM AUTHOR]