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Abstract: A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48μmol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV–vis spectroscopy. [Copyright &y& Elsevier]

Abstract: Three mononuclear polypyridyl complexes of Ni(II), [Ni(Ph2phen)3](PF6)2·CH3CN (1), [Ni(dpa)2(phen)](PF6)2 (2) and [Ni(bpy)3](PF6)2 (3), where Ph2phen is 4,7-diphenyl-1,10-phenanthroline, dpa is 2,2′-dipyridylamine, bpy is 2,2′-bipyridine, and phen is 1,10-phenanthroline, were prepared and their solid state structures determined by single-crystal X-ray crystallography. The structural determination shows that the coordination geometry around the Ni(II) center is a distorted octahedron in each complex. The investigation of synthesis procedure and crystallographic data of complex 3 indicates the spontaneous resolution of supramolecular chirality. A careful inspection of the packing pattern in the lattice of each complex reveals that non-covalent interactions of two different types, viz. C–H⋯F and C–H⋯π interactions, are active in the lattice. The packing structures of 1–3 also show that the rings of the polypyridyl ligands, Ph2phen, dpa, bpy, and phen, are not located face-to-face and can not interact through π–π interactions. Cyclic voltammetry data of 1 and 3 show that the Ni(III/II) reduction couple is quasi-reversible and this reduction becomes progressively more difficult on passing from bpy to Ph2phen, while complex 2 shows an irreversible behavior with the peak-to-peak separation of about 500mV. Magnetic susceptibility data derived from paramagnetic NMR revealed effective magnetic moments of 3.12BM for 1, 3.27BM for 2, and 3.14 for 3 at room temperature. [Copyright &y& Elsevier]

Abstract: A one-pot triphenylarsine-catalyzed synthesis of trans-cyclopropane derivatives is achieved by means of the reaction between acetylenic esters and C–H acids in the presence of triphenylarsine. This procedure is simple and proceeds under mild reaction conditions. Its success depends on the choice of solvent, temperature and C–H acid used. [Copyright &y& Elsevier]

Abstract: A facile diastereoselective synthesis of highly functionalised 3-(1-diphenylphosphonylethyl)butyrolactone analogues, 3a–c is achieved from the reaction of dialkyl acetylenedicarboxylates, 2a,b, with thiolated and trifluoromethylated-1,3-diones, CH acids, 1a,b, in the presence of triphenyl phosphite. The resulting products, 3a–c, are obtained in high yields and characterised by 1H/13C, 19F, 31P NMR and X-ray crystallography. [Copyright &y& Elsevier]