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Introduction/Background The biopsychosocial model of the ICF comprises more than 1400 categories. These categories need to be operationalized, to guarantee clinical applicability, through the development of instruments that describe the functioning and disability of patients in different contexts or health conditions. Aim: To describe the process of operationalization and subsequent verification of the inter-rater reliability of a set of ICF categories for adult patients treated for cancer at hospital discharge. Material and method Corresponds to an observational validation study. A previous process of systematic review and expert consensus selected 24 ICF categories, which were operationalized in a formal decision-making consulting different experts in the subject - health professionals with experience in the clinical management of patients with cancer. Subsequently, these operationalized categories were exposed to verification of inter-rater reliability by two trained raters in a sample of 31 patients with different types of cancer in two public Hospitals in Santiago, Chile. This study was approved by the Ethics Committee. Results 24 CIF categories were operationalized using a scale of 0 to 4 corresponding to the CIF scale.The average age of the participants was 54.2 (of = 19) years. In relation to inter-rater reliability, the only item that did not present a correlation between both evaluations was d240 regarding stress management. In this way, this item was excluded from the instrument because it was very ambiguous. The other items obtained significant correlations that varied from r = .916 to r = 1.0 (perfect correlation). Conclusion This process resulted in the operationalization of 23 CIF categories relevant to the context of patients hospitalized for cancer, which obtained good inter-rater reliability. More research is suggested investigating other psychometric properties of this set of operationalized categories. [ABSTRACT FROM AUTHOR]