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Start Over Author "Louis, B." Publisher elsevier b.v.
275 results on '"Louis, B."'

27. Veterans Affairs Radiation Oncology Quality Surveillance Program and American Society for Radiation Oncology Quality Measures Initiative.

Author

Park, John, Puckett, Lindsay L., Katsoulakis, Evangelia, Venkatesulu, Bhanu Prasad, Kujundzic, Ksenija, Solanki, Abhishek A., Movsas, Benjamin, Simone II, Charles B., Sandler, Howard, Lawton, Colleen A., Das, Prajnan, Wo, Jennifer Y., Buchholz, Thomas A., Fisher, Christine M., Harrison, Louis B., Sher, David J., Kapoor, Rishabh, Chapman, Christina H., Dawes, Samantha, and Kudner, Randi

Abstract

Ensuring high quality, evidence-based radiation therapy for patients is of the upmost importance. As a part of the largest integrated health system in America, the Department of Veterans Affairs National Radiation Oncology Program (VA-NROP) established a quality surveillance initiative to address the challenge and necessity of providing the highest quality of care for veterans treated for cancer. As part of this initiative, the VA-NROP contracted with the American Society for Radiation Oncology to commission 5 Blue Ribbon Panels for lung, prostate, rectal, breast, and head and neck cancers experts. This group worked collaboratively with the VA-NROP to develop consensus quality measures. In addition to the site-specific measures, an additional Blue Ribbon Panel comprised of the chairs and other members of the disease sites was formed to create 18 harmonized quality measures for all 5 sites (13 quality, 4 surveillance, and 1 aspirational). The VA-NROP and American Society for Radiation Oncology collaboration have created quality measures spanning 5 disease sites to help improve patient outcomes. These will be used for the ongoing quality surveillance of veterans receiving radiation therapy through the VA and its community partners. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Environmental enrichment reduces A-beta levels and amyloid deposition in transgenic mice

Author

Lazarov, Orly, Robinson, John, Ya-ping Tang, Hariston, IIana S., Zelka Korade-Mirnics, Lee, Virginia M. Y., Hersh, Louis B., Sapolsky, Robert M., Mirnics, Karoly, and Sisodia, Sangram S.

Subjects
Biological sciences
Abstract

Studies provide evidence that environmental enrichment leads to reductions in steady-state levels of cerebral amyloid-beta peptides and amyloid deposition and selective upregulation in levels of specific transcripts in brains of trangenic mice. The enzymatic activity of an amyloid-beta degrading endopeptidase, nephrilysin, is elevated in the brains of 'enriched' mice and inversely correlated with amyloid burden.

Published
2005

33. The role of wax comb in honey bee nestmate recognition

Author

Breed, Michael D., Garry, Melissa F., Pearce, Alison N., Hibbard, Bruce E., Bjostad, Louis B., and Page, Robert E., Jr.

Subjects
Honeybee -- Behavior, Beeswax -- Genetic aspects, Zoology and wildlife conservation
Abstract

There is a genetic component to nestmate identification cues received from comb wax and these cues are transferred between worker honey bees, Apis mellifera. Studies also place importance on hive environment and comb wax in particular for cue acquisition by worker honey bees. The findings support the importance of wax in honey bee nestmate identification. A genetic component of this discrimination was also discovered.

Published
1995

37. Extended anterior craniofacial resection for intracranial extension of malignant tumors

Author

Bilsky, Mark H., Kraus, Dennis H., Strong, Elliot W., Harrison, Louis B., Gutin, Philip H., and Shah, Jatin P.

Subjects
Head and neck tumors, Health
Abstract

OBJECTIVE: To review our experience with anterior craniofacial resection for malignant neoplasms with intracranial extension. Survival was analyzed in terms of presence of intracranial extension, extent of intradural disease, tumor histology, and histological status of margins. PATIENTS: In a retrospective review made at a tertiary cancer facility, 26 of the 115 consecutive patients undergoing craniofacial resection for malignant lesions of the anterior skull base had intracranial extension, defined as dural and/or brain extension. Survival was evaluated with the Kaplan-Meier product limit method, and comparisons between individual subgroups were performed using the log-rank test RESULTS: Patients with intradural extension have a statistically worse disease-specific survival than patients without intracranial extension (P = 0.05). Surgical margins and tumor histology impact on survival. The incidence of local complications was 42% and of systemic complications, 8%. CONCLUSION: Anterior craniofacial resection is indicated for patients with resectable disease. The complication rate is comparable with that of patients without intracranial extension. Gross total resection with histologically negative margins portends a better prognosis. Esthesioneuroblastoma has a better prognosis than other tumor types.

Published
1997

39. Long-term subjective functional outcome of surgery plus postoperative radiotherapy for advanced stage oral cavity and oropharyngeal carcinoma

Author

Zelefsky, Michael J., Gaynor, Jeffrey, Kraus, Dennis, Strong, Elliot W., Shah, Jatin P., Harrison, Louis B., and Bumpous, Jeffrey M.

Subjects
Head and neck cancer -- Care and treatment, Mouth cancer -- Care and treatment, Health
Abstract

BACKGROUND: Although long-term cures have been achieved for locally advanced squamous cell carcinomas of the head and neck, there is a paucity of information available regarding patients' perspectives of their functional outcome. PATIENTS AND METHODS: Thirty-five long-term survivors free of disease following surgery and postoperative radiotherapy for advanced cancers of the oral cavity and oropharynx were sent questionnaires to evaluate their long-term functional outcome after therapy. The questionnaires included a subjective performance status scale that assessed the patient's perceived (1) ability to eat in public, (2) understandability of speech, and (3) normalcy of diet. Twenty-nine of 35 patients participated in this function assessment and are the subjects of this report. RESULTS: The mean function scores for all patients were as follows: 72 for eating in public, 69 for understandability of speech, and 58 for normalcy of diet. Functional results were further analyzed by T stage and anatomic subsite. Inferior results were noted with increasing T stage. A two-way analysis of variance showed that this difference was significant even after adjusting for the effect of anatomic subsite (P = 0.0002, P = 0.018, and P = 0.0018 for the three outcome variables). in addition, patients with base of tongue lesions had a worse functional outcome for both early T stage (T1/T2) and advanced T stage (T3/T4) when compared to other subsites. This difference averaged across T stage was statistically significant for understandability of speech (P = 0.0019) and normalcy of diet (P = 0.013), but was not significant for eating in public (P = 0.16). CONCLUSIONS: This performance status scale was found to be a useful tool for functional assessment following definitive therapy for advanced stage head and neck carcinomas. These subjective functional scores deteriorated with increasing T stage. In addition, functional scores for oral tongue, floor of mouth, and tonsillar primaries were superior to those for base of tongue lesions. These functional outcome scores are consistent with the extent of surgery required for the base of tongue subsite and are in direct relation to the patients' T stage in this study population.

Published
1996

43. Personalizing Radiotherapy Prescription Dose Using Genomic Markers of Radiosensitivity and Normal Tissue Toxicity in NSCLC.

Author

Scott, Jacob G., Sedor, Geoff, Scarborough, Jessica A., Kattan, Michael W., Peacock, Jeffrey, Grass, G. Daniel, Mellon, Eric A., Thapa, Ram, Schell, Michael, Waller, Anthony, Poppen, Sean, Andl, George, Teer, Jamie K., Eschrich, Steven A., Dilling, Thomas J., Dalton, William S., Harrison, Louis B., Fox, Tim, and Torres-Roca, Javier F.

Published
2021
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50. Novel Genomic-Based Strategies to Personalize Lymph Node Radiation Therapy.

Author

Oliver, Daniel E., Mohammadi, Homan, Figura, Nicholas, Frakes, Jessica M., Yamoah, Kosj, Perez, Bradford A., Wuthrick, Evan J., Naghavi, Arash O., Caudell, Jimmy J., Harrison, Louis B., Torres-Roca, Javier F., and Ahmed, Kamran A.

Abstract

Current standard radiotherapy doses have been derived from empiric methods rather than a scientific framework. Subclinical nodal dosing remains relatively uniform across most disease sites, despite heterogeneity in patient and tumor biology. It is now clear that there are subsets of patients who will benefit from genomically-informed radiotherapy planning, and there are increasing efforts toward prescribing radiation dose to match the radiosensitivity of the tumor. By using novel genomic biomarkers to personalize delivery of radiotherapy, there is an opportunity to improve loco-regional control and cure rates. We survey the current landscape of personalized radiation oncology across commonly treated disease sites. [ABSTRACT FROM AUTHOR]

Published
2019
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