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Your search keyword '"Loria, G"' showing total 4 results
Start Over Author "Loria, G" Publisher elsevier b.v.
4 results on '"Loria, G"'

1. DHA effects in Parkinson disease depression.

Author

Pomponi, M., Loria, G., Salvati, S., Di Biase, A., Conte, G., Villella, C., Righino, E., Ciciarelli, C., Bria, P., La Torre, G., Pomponi, M.F.L., Janiri, L., and Bentivoglio, A.R.

Abstract

Abstract: A growing importance has been placed on the recognition and supervision of non-motor features of Parkinson's disease (PD). Depression has been estimated to affect one in three individuals with PD and can lead to worse health outcomes and decreased quality of life. Anxiety, apathy and anhedonia further complicate PD outcomes. In this double-blind, placebo-controlled trial, participants (individuals with mild to moderate PD; n =24) were randomly assigned to treatment (800mg/d docosahexaenoic acid (DHA) and 290mg/d eicosapentaenoic acid, a precursor to DHA) or placebo (an equicaloric amount of corn oil). Treatment duration was 6 months. Treatment had no statistically significant effect on rate of change on either Unified Parkinson's Disease Rating Scale or Hoehn-Yahr Scale score. However, 75% of DHA-treated patients, reduced Hamilton Rating Scale for Depression total score by at least 50%, compared with only 25% into the placebo group. At the end of the six-month study, DHA integration reduced the depressive symptoms. [Copyright &y& Elsevier]

Published
2014
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4. Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells

Author

Guido Ruggero Loria, Stefano Agnello, Giovanna Pitarresi, Roberto Puleio, Gaetano Giammona, Fabio Salvatore Palumbo, Calogero Fiorica, Palumbo, F., Agnello, S., Fiorica, C., Pitarresi, G., Puleio, R., Loria, G., and Giammona, G.

Subjects
Hyaluronic acid, 0206 medical engineering, Pharmaceutical Science, 02 engineering and technology, Dexamethasone, Extracellular matrix, chemistry.chemical_compound, Tissue engineering, Transforming Growth Factor beta, Cell Adhesion, Humans, Cell adhesion, Cells, Cultured, Bottom-up approach, Stem cell, Mesenchymal Stromal Cell, Tissue Engineering, Chemistry, Mesenchymal stem cell, Mesenchymal Stem Cells, Cell Differentiation, Adhesion, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Extracellular Matrix, Biochemistry, Microparticle, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, Surface modification, Chondrogenesi, 0210 nano-technology, Chondrogenesis, Human
Abstract

Spray-dried microparticles of a derivative of hyaluronic acid (HA) have been engineered to obtain a controlled aggregation with Human Mesenchymal Stem Cells (hMSCs) into 3D constructs. We demonstrated the utility of chemical functionalization of a native constituent of the extracellular matrix to improve processing performances and to control on stem cell adhesion and differentiation. Native hyaluronic acid (HA), cell adhesive peptides (RGD), transforming growth factor β3, dexamethasone are biological agents potentially suitable for chondrogenic stimulation of hMSCS. However unmodified HA suffers of drawbacks in terms of stability and versatility of processing. Functionalization strategies are needed to overcome these drawbacks. In this paper microparticles were produced by spray-drying of an aliphatic and amino functionalized HA derivative. Hydrophobic derivatization of HA allowed the production of microparticles stabilized by physical crosslinking and to load and to control dexamethasone release. The presence of pendant amino groups was exploited to tether cyclic RGD and transforming growth factor β3 via maleimide chemistry; cyRGDC functionalization controlled hMSCs/microparticles aggregation. Chondrogenic potential was preliminary assayed by qualitative immunohistological detection.

Published
2017

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