7 results on '"Lonero, A."'
Search Results
2. Mantle plumes sample heterogeneous mixtures of oxidized and reduced lithologies
- Author
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Nicklas, Robert W., Baxter, Ethan F., Brandon, Alan D., Lonero, Andrew J., and Day, James M.D.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
3. Uniparental disomy and pretreatment IGF-1 may predict elevated IGF-1 levels in Prader-Willi patients on GH treatment.
- Author
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Palmieri, Viviana Valeria, Lonero, Antonella, Bocchini, Sarah, Cassano, Gilda, Convertino, Alessio, Corica, Domenico, Crinò, Antonio, Fattorusso, Valentina, Ferraris, Silvio, Fintini, Danilo, Franzese, Adriana, Grugni, Graziano, Iughetti, Lorenzo, Lia, Rosanna, Macchi, Francesca, Madeo, Simona Filomena, Matarazzo, Patrizia, Nosetti, Luana, Osimani, Sara, and Pajno, Roberta more...
- Abstract
Pediatric patients with Prader-Willi syndrome (PWS) can be treated with recombinant human GH (rhGH). These patients are highly sensitive to rhGH and the standard doses suggested by the international guidelines often result in IGF-1 above the normal range. We aimed to evaluate 1 the proper rhGH dose to optimize auxological outcomes and to avoid potential overtreatment, and 2 which patients are more sensitive to rhGH. In this multicenter real-life study, we recruited 215 patients with PWS older than 1 year, on rhGH at least for 6 months, from Italian Centers for PWS care. We collected auxological parameters, rhGH dose, IGF-1 at recruitment and (when available) at start of treatment. The rhGH dose was 4.3 (0.7/8.4) mg/m
2 /week. At recruitment, IGF-1 was normal in 72.1% and elevated in 27.9% of the patients. In the group of 115 patients with IGF-1 available at start of rhGH, normal pretreatment IGF-1 and uniparental disomy were associated with elevated IGF-1 during the therapy. No difference in height and growth velocity was found between patients treated with the highest and the lowest range dose. The rhGH dose prescribed in Italy seems lower than the recommended one. Normal pretreatment IGF-1 and uniparental disomy are risk factors for elevated IGF-1. The latter seems to be associated with higher sensitivity to GH. In case of these risk factors, we recommend a more accurate titration of the dose to avoid overtreatment and its potential side effects. • Height, growth velocity and BMI of the lowest rhGH dose quartile are similar to those of the highest one • In our study, PWS patients are on 4.3 mg/m2 /week of rhGH and IGF-1 is above the normal range in about 28% of the patients • Low pretreatment IGF-1 and deletion of the paternal 15q11.2–q13 region predict normal IGF-1 during the rhGH treatment • Patients with PWS due to uniparental disomy seem to feature a higher sensitivity to rhGH than patients with deletion [ABSTRACT FROM AUTHOR] more...- Published
- 2019
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4. Allele frequencies of the new European Standard Set (ESS) loci in a population of Apulia (Southern Italy).
- Author
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Piglionica, M., Lonero Baldassarra, S., Giardina, E., Tonino Marsella, L., Resta, N., and Dell’Erba, A.
- Subjects
GENE frequency ,POLYMERASE chain reaction ,GENE amplification ,HARDY-Weinberg formula ,GENETIC polymorphisms - Abstract
Abstract: Allele frequencies of five miniSTRs loci (D1S1656, D2S441, D12S391, D10S1248 and D22S1045) included in the new European Standard Set (ESS) were calculated from a sample of 150 unrelated individuals from Apulia, a Region of Southern Italy. Two different PCR Amplification Kits were used, in order to evaluate the concordance of the genotypes. The results obtained with the two kits showed no differences in all genotype profiles. No deviation from Hardy–Weinberg expectations was detected at either locus. Moreover genetic analysis using Fst estimation showed no evidence for differentiation at the five new loci between Apulia and Italian populations. The high levels of polymorphisms of the analyzed markers in the Apulian population allow to confirm that these markers are useful tools in paternity and forensic analysis from degraded DNA samples. [Copyright &y& Elsevier] more...
- Published
- 2013
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- View/download PDF
5. Population data for 17 Y-chromosome STRs in a sample from Apulia (Southern Italy).
- Author
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Piglionica, M., Baldassarra, S. Lonero, Giardina, E., Stella, A., D’Ovidio, F.D., Frati, P., Lenato, G.M., Resta, N., and Dell’Erba, A.
- Subjects
Y chromosome ,TANDEM repeats ,NUCLEOTIDE sequence ,DNA analysis ,HAPLOTYPES ,GENE amplification ,GENETIC markers - Abstract
Abstract: The 17 Y-STR loci included in the AmpFLSTR Yfiler PCR Amplification Kit were analyzed in 98 unrelated healthy males from Apulia (Southern Italy). A total of 97 different haplotypes were identified, of which 96 haplotypes were unique and 1 occurred twice. Allele frequencies for each Y-STR locus in pooled sample and estimated value of gene diversity (GD) were evaluated. The lowest value of GD was observed for DYS392 (0.126) and the highest one (0.936) for DYS385. The HD (haplotype diversity) for the studied Y-STR set showed a value of 0.9994, with an HMP (haplotype match probability) value of 0.0006, while the overall DC was 98.98%. Microvariant alleles were found for the DYS458 and DYS385 markers and sequenced. Furthermore, Φ
st -based genetic distance computation and pair-wise analysis of molecular variance (AMOVA) test were carried out. When comparing our population with the Apulia sample previously investigated, the AMOVA analysis detected no evidence for significant differentiation. The comparison with all Italian populations submitted to the YHRD website showed no relevant differences with all Southern Italian populations (San Giorgio La Molara, Belvedere, Trapani and Catania) and significant genetic deviation with all Northern Italian populations (Udine, Biella, La Spezia, Modena, Ravenna, Marche and North Sardinia). Moreover, the other populations and meta-populations belonging to the whole Mediterranean area (Croatia, Macedonia, Albania, Greece, Turkey, Israel, Libya, Tunisia, Algeria, Morocco and Spain) were different from our Apulia sample. The data were submitted to YHRD. [Copyright &y& Elsevier] more...- Published
- 2013
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6. Trends in Driver Education and Training
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Lonero, Lawrence P.
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PREVENTIVE medicine , *MEDICINE , *MEDICAL care , *AUTOMOBILE driver education - Abstract
Abstract: This article provides an overview of trends in beginner, pre-licensing driver education and a perspective on the potential for systematic program evaluation to improve driver education programs, policy, and management. It provides a brief digest of the conclusions, limitations, and implications of the evaluation literature for driver education program practice and development. [Copyright &y& Elsevier] more...
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- 2008
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7. On-road and simulated driving: Concurrent and discriminant validation
- Author
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Mayhew, Daniel R., Simpson, Herb M., Wood, Katherine M., Lonero, Lawrence, Clinton, Kathryn M., and Johnson, Amanda G.
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AUTOMOBILE driving , *AUTOMOBILE driver education , *DISCRIMINANT analysis , *DRIVERS' licenses , *PERFORMANCE evaluation , *CONCORDANCES (Topology) , *ERROR analysis in mathematics , *TESTING - Abstract
Abstract: Introduction: A converging pair of studies investigated the validity of a simulator for measuring driving performance/skill. Study 1: A concurrent validity study compared novice driver performance during an on-road driving test with their performance on a comparable simulated driving test. Results: Results showed a reasonable degree of concordance in terms of the distribution of driving errors on-road and errors on the simulator. Moreover, there was a significant relationship between the two when driver performance was rank ordered according to errors, further establishing the relative validity of the simulator. However, specific driving errors on the two tasks were not closely related suggesting that absolute validity could not be established and that overall performance is needed to establish the level of skill. Study 2: A discriminant validity study compared driving performance on the simulator across three groups of drivers who differ in their level of experience - a group of true beginners who had no driving experience, a group of novice drivers who had completed driver education and had a learner''s permit, and a group of fully licensed, experienced drivers. Results: The findings showed significant differences among the groups in the expected direction -- the various measures of driving errors showed that beginners performed worse than novice drivers and that experienced drivers had the fewest errors. Collectively, the results of the concurrent and discriminant validity studies support the use of the simulator as a valid measure of driving performance for research purposes. Impact on industry: These findings support the use of a driving simulator as a valid measure of driving performance for research purposes. Future research should continue to examine validity between on-road driving performance and performance on a driving simulator and the use of simulated driving tests in the evaluation of driver education/training programs. [Copyright &y& Elsevier] more...
- Published
- 2011
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