Search

Your search keyword '"Locati, Laura Deborah"' showing total 6 results
Start Over Author "Locati, Laura Deborah" Publisher elsevier b.v.
6 results on '"Locati, Laura Deborah"'

3. O180 / #616 - RADGESS: PRELIMINARY RESULTS OF THE IN SILICO STUDY FOR RADIORESISTANCE GENOMIC SIGNATURES IN SINONASAL CANCERS EXPERIMENTAL MODELS AFTER PARTICLE THERAPY

Author

Giorgia, Fulgini, Charalampopoulou, Alexandra, Molinelli, Silvia, Pullia, Marco, Codina-Martinez, Helena, Lenoci, Deborah, Lucchetta, Marta, Takahashi, Yoko, Hanna, Hehab, Locati, Laura Deborah, Ivaldi, Giovanni B, De Cecco, Loris, Hermsen, Mario, Facoetti, Angelica, and Orlandi, Ester

Published
2024
Full Text
View/download PDF

5. Failure of Further Validation for Survival Nomograms in Oropharyngeal Cancer: Issues and Challenges.

Author

Bossi, Paolo, Miceli, Rosalba, Granata, Roberta, Naimo, Simona, Infante, Gabriele, Locati, Laura Deborah, Iacovelli, Nicola Alessandro, Fallai, Carlo, Licitra, Lisa, and Orlandi, Ester

Subjects
*OROPHARYNGEAL cancer, *CANCER radiotherapy, *ALCOHOL drinking, *DISEASE progression, *CANCER genetics, *CANCER treatment, *CALIBRATION, *COMPARATIVE studies, *HEALTH status indicators, *RESEARCH methodology, *MEDICAL cooperation, *PROGNOSIS, *RESEARCH, *SOCIOECONOMIC factors, *EVALUATION research, *TREATMENT effectiveness, *RETROSPECTIVE studies, *STATISTICAL models, *KAPLAN-Meier estimator, RESEARCH evaluation
Abstract

Purpose: To retrospectively test 2 nomograms recently validated as prognostic tools for patients with oropharyngeal cancer treated with curative radiation-based therapy, in 184 consecutive subjects treated from April 2004 to January 2016.Patient and Methods: Complete information regarding disease, survival status, and nomogram covariates was retrieved for 174 patients, with a median follow-up of 51 months. Calibration of the nomograms was obtained by evaluating the ability to accurately predict the absolute risk level; discriminative ability estimated by the Harrell C statistic was tested by assessing the ability of the nomograms to rank the patients from low risk to high risk.Results: The outcome predicted by the nomograms was worse than observed, especially for progression-free survival. This may be due to several factors: geographic and genetic background, smoking, alcohol use, the different national health system organization, which provides universal and free-of-charge coverage to all individuals, and the setting of treatment in clinical practice, outside of clinical trials.Conclusions: Our results show that the usefulness of nomograms to predict outcome of oropharyngeal cancer may not be generalizable to patients of different countries. Further studies are needed to clarify whether sociodemographic, epidemiologic, and cultural scenarios may seriously affect the prognostic ability of newly developed predictive tools. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

6. In Reply to Fakhry et al.

Author

Bossi, Paolo, Miceli, Rosalba, Granata, Roberta, Naimo, Simona, Infante, Gabriele, Locati, Laura Deborah, Iacovelli, Nicola Alessandro, Fallai, Carlo, Orlandi, Ester, and Licitra, Lisa

Subjects
*PROGRESSION-free survival, *PROBABILITY theory, *CONFIDENCE intervals
Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results