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Preeclampsia is a pregnancy-specific syndrome and is one of the main causes of maternal, fetal, and neonatal morbidity and mortality. Inadequate trophoblast invasion and failure of uterine spiral artery remodeling exert a major role in the development of preeclampsia, especially the early-onset one. LncRNA-ATB is verified to be aberrantly expressed in many cancers and promote the invasion-metastasis and proliferation cascades. But little is known of lncRNA-ATB's role in preeclampsia. The aim of current study is to identify the changes of lncRNA-ATB in preeclampsia and its effects on trophoblast. The lncRNA-ATB levels were decreased in placental samples collected from preeclampsia women (n = 51) compared to those of healthy pregnant women (n = 40) by qRT-PCR analysis. Besides, it is demonstrated that lncRNA-ATB was intense stained in the trophoblast of the placenta by performing in-situ hybridization. By designing RNA interference species to suppress lncRNA-ATB and specific plasmids designed to overexpress lncRNA-ATB, we identify the role of lncRNA-ATB on the functions of trophoblast cell-line, HTR-8/SVneo. Inhibition of endogenous lncRNA-ATB decreased migration, proliferation, tube-formation of HTR-8/SVneo cells. In addition, overexpression of lncRNA-ATB promoted migration, proliferation, and tube-formation of HTR-8/SVneo cells. Therefore, lncRNA-ATB might be involved in the pathogenesis of preeclampsia by regulating the process of trophoblast invasion and endovascular formation. [ABSTRACT FROM AUTHOR]

Abstract: Objective: Preeclampsia, a multisystem disorder unique to pregnancy, is a major cause of maternal and perinatal mortality and morbidity. Inadequate trophoblast invasion and vascular dysfunction are believed to be involved in preeclampsia. Axl, which interacts with its ligand Gas6, known to regulate cell migration, adhesion, and vascular angiogenesis or homeostasis and vascular network formation, may be implicated in preeclampsia, as preeclampsia is a specific vascular disease. sAxl, a soluble form of Axl, is bound to Gas6 in plasma, which inhibits the activation of the Axl–Gas6 pathway. The aim of this study was to determine the changes and significance of plasma concentrations of sAxl in severe preeclampsia, as well as its correlation with the clinical parameters of severe preeclampsia. Design and methods: Fifty-eight women with severe preeclampsia and 31 healthy pregnant women were included in the study, from April 2012 to October 2012. Plasma sAxl concentrations were detected with an immunosorbent assay (ELISA) kit. Results: Plasma sAxl concentrations were significantly higher in the preeclampsia group (61.52±17.57ng/mL) than in the normal pregnancy group (45.29±15.44ng/mL) (P<0.05). Plasma sAxl concentrations in the severe preeclampsia patients correlated positively with systolic and diastolic blood pressures (r=0.628, P<0.05 vs. r=0.394, P<0.05, respectively) and proteinuria (r=0.583, P<0.05), but inversely with plasma albumin (r=−0.444, P<0.05), gestation of delivery (r=−0.554, P<0.05), and birth weight (r=−0.476, P<0.05). Multiple linear regression analysis indicated that systolic blood pressure and proteinuria were influence factors of plasma sAxl levels (β1=0.520, P<0.05; β2=0.461, P<0.05). Conclusions: Plasma sAxl concentrations were higher in the preeclampsia patients, and plasma sAxl levels were correlated with the clinical parameters of severe preeclampsia. Furthermore, systolic blood pressure and proteinuria might be influence factors of plasma sAxl level. [Copyright &y& Elsevier]

The dispersion behaviors of metal oxygen species on the carrier surface have an important effect on the performances of them. The dispersion behaviors of cerium oxygen (CeO x) species on the surface of Canna indica L. based biochar are investigated via anchoring the different amounts of Ce(NO 3) 3 onto the surface of biochar by a hydrothermal reaction method. The dispersion behaviors are characterized by XRD, SEM, EDS. The effect of dispersive behavior on its own properties can be characterized by Raman, XPS and BET. The CO 2 adsorption performances of the different dispersive behaviors are detected by gas chromatography. Results showed that the dispersion behaviors of CeO x species on the biochar is affected by the molar ratio of CeO x species and biochar. In addition, the specific surface area, pore volume and average pore diameter of the composites, the interaction between with CeO x species and carrier biochar and the concentration of oxygen vacancy in CeO x species are all affected by the dispersion behaviors of the loaded CeO x species. Most importantly, the CO 2 adsorption performance of the composites are different duo to the different dispersion behaviors. CeO x -5/bio-C (the composite with the molar ratio of CeO x species and biochar is 5%) has the highest CO 2 adsorption performance and the adsorption capacity is 112.88 μmol/g CeO2. Therefore, the dispersion behavior of the CeO x species on the surface of the carrier has a great influence on its own properties and adsorption performance. [Display omitted] • CeO x -based composites were successfully prepared for CO 2 capture. • A CO 2 adsorption capacity of 112.88 μmol/g CeO 2 was attained at ambient condition. • Oxygen vacancies on the surface of CeO 2 promoted adsorption performance • Effect of dispersion behavior on the adsorption performance was discussed. • In situ adsorption property and adsorption mechanism of CO 2 on CeO x were proposed. [ABSTRACT FROM AUTHOR]