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Your search keyword '"Liu, Moqi"' showing total 5 results
Start Over Author "Liu, Moqi" Publisher elsevier b.v.
5 results on '"Liu, Moqi"'

4. Transformer-enhanced two-stream complementary convolutional neural network for hyperspectral image classification.

Author

Pan, Haizhu, Yan, Hui, Ge, Haimiao, Liu, Moqi, and Shi, Cuiping

Subjects
*CONVOLUTIONAL neural networks, *IMAGE recognition (Computer vision), *FEATURE extraction, *TRANSFORMER models
Abstract

Convolutional neural networks (CNNs) and Transformers have been widely employed in hyperspectral image (HSI) classification, due to their advantages in extracting local-range and global-range features respectively. However, some hybrid CNNs and Transformer-based methods still face some shortcomings in effectively exploiting local-global features in HSI. In this article, a Transformer-enhanced two-stream complementary convolutional neural network is proposed for HSI classification. It mainly comprises the spectral feature extraction stream, spatial feature extraction stream, and a spectral-spatial weight feature complementary module. Firstly, in spectral feature extraction stream, a hybrid convolution block is proposed to extract high-resolution spectral features. And then an attention mechanism, which is based on a Transformer encoder, is used to learn key informative features in spectral channel. The spatial feature extraction stream is designed for spatial feature extraction, and it has a similar architecture to the spectral feature extraction stream. Secondly, a spectral-spatial weight feature complementary module is developed to fully exploit the features which are based on the feature weight in spectral tokens and spatial tokens, they are from spectral and spatial feature extraction streams separately, and then the spectral-spatial tokens with different semantic features are derived. Finally, the spectral-spatial tokens are fed into the linear layer to produce classification outcomes. Furthermore, simplified convolution kernels are employed in our proposed method to decrease the total parameters. Results from experiments on four extensively used HSI datasets highlight the superior performance of our proposed method over other cutting-edge methods. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Pharmaceutical salts/cocrystals of enoxacin with dicarboxylic acids: Enhancing in vitro antibacterial activity of enoxacin by improving the solubility and permeability.

Author

Liu, Lixin, Zou, Dongyu, Zhang, Yunan, Zhang, Qiang, Feng, Yanru, Guo, Yingxue, Liu, Yingli, Zhang, Xuesong, Cheng, Guangdong, Wang, Chaoxing, Zhang, Yunjie, Zhang, Lei, Wu, Lili, Chang, Liang, Su, Xin, Duan, Yu, Zhang, Yanfei, and Liu, Moqi

Subjects
*SOLUBILITY, *PERMEABILITY, *OXALIC acid, *FUMARATES, *DICARBOXYLIC acids, *THERAPEUTIC equivalency in drugs, *MALONIC acid
Abstract

• Designing and synthesizing three pharmaceutical salts/cocrystals of enoxacin (EX) • Tuning solubility of EX by forming salts/cocrystals with dicarboxylic acids. • Improving the solubility and permeability of EX by forming salts/cocrystals. • Enhancing antibacterial activity of EX by improving the solubility and permeability. Base on improving the solubility and permeability of enoxacin (EX) to enhance the antibacterial activity in vitro, three new pharmaceutical salts/cocrystals of EX with oxalic acid (EX·0.5(C 2 H 2 O 4)·2(H 2 O)), malonic acid ((HEX)·C 3 H 3 O 4) and fumaric acid ((HEX)·C 4 H 3 O 4) have been designed, synthesized and characterized. Comprehensive analysis structure and Hirshfeld surface reveal that the hydrogen bonds/CAHBs formed by the N atom in the piperazine ring from EX molecule with the carboxylic acid group in the coformer could form a stable crystal structure. It is universally acknowledged that improving the solubility of the EX (BCS class II) to make it a BCS class I drug would obtain a Bioequivalence of immunity to the drug trial. The solubilities of three pharmaceutical salts/cocrystals of EX with dicarboxylic acids are consistent with expectation that they are dramatically improved in pure water than pure enoxacin, and the solubility order of three pharmaceutical salts/cocrystals of EX is consistent with coformers solubility. The permeabilities of three pharmaceutical salts/cocrystals of EX are improved compared with the pure enoxacin, and the variation tendency is consistent with the solubilities of three pharmaceutical salts/cocrystals of EX. In addition, the antibacterial activities in vitro of three pharmaceutical salts/cocrystals of EX are improved compared with the corresponding parent compound (EX), which change the order is consistent with the solubility and permeability. Simultaneously, the hygroscopic stabilities of three pharmaceutical salts/cocrystals are surpassing pure EX, and the hygroscopic stability of molecular cocrystal EX-OXA is better than ionic cocrystal EX-MLO and EX-FUM. This implies that preparation of the pharmaceutical salts/cocrystals of EX with oxalic acid, malonic acid and fumaric acid could not only enhance the antibacterial activity of EX, which base on improving the solubility and permeability of EX, but also improve the hygroscopic stability of EX. [ABSTRACT FROM AUTHOR]

Published
2020
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