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Simulated transmission spectrums and the change of the transmission peak position with the refractive index by the finite-difference time-domain method are present. The considered structure is the two-dimensional metallic square hole and trapezoid hole array, and the change of the transmission peak position with the refractive index can achieve about 1000 nm RIU −1 . In comparison, the sensor properties of the metallic trapezoid hole array is better than that of the metallic square hole array. Meanwhile, the field intensity enhancement and localization of the metallic trapezoid hole are better. Meanwhile, these array structures can extensively apply to biochemical sensor devices design and localized field enhancement device so on. [ABSTRACT FROM AUTHOR]

Abstract: The near field intensity distribution and the near-field transmission spectrums of metallic nanostructures simulated by the finite-difference time-domain method are present in the text. Better field intensity localization and larger field intensity enhancement exist in the near field intensity distribution images for nanoparticle array in the near-infrared wavelength range. The minimum transmission intensity collected at the metal film surface can exceed 1.0 and the electric field intensity can limit in a number of nanometer. Meanwhile, these nanoparticle array structures can extensively apply to biochemical sensor devices design and so on. [Copyright &y& Elsevier]

Abstract: A series of tacrine–coumarin hybrids (8a–t) were designed, synthesized and evaluated as multifunctional cholinesterase (ChE) inhibitors against Alzheimer's disease (AD). The screening results showed that most of them exhibited a significant ability to inhibit ChE and self-induced β-amyloid (Aβ) aggregation, and to act as metal chelators. Especially, 8f displayed the greatest ability to inhibit acetylcholinesterase (AChE, IC50 = 0.092 μM) and Aβ aggregation (67.8%, 20 μM). It was also a good butyrylcholinesterase inhibitor (BuChE, IC50 = 0.234 μM) and metal chelator. Besides, kinetic and molecular modeling studies indicated that 8f was a mixed-type inhibitor, binding simultaneously to active, peripheral and mid-gorge sites of AChE. These results suggested that 8f might be an excellent multifunctional agent for AD treatment. [Copyright &y& Elsevier]