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Purpose: To evaluate safety and efficacy of percutaneous mechanical thrombectomy using the Rotarex catheter combined with drug-coated balloon (DCB) in treatment of femoropopliteal artery occlusive disease.Materials and Methods: Between January 2016 and February 2018, 81 patients with acute or subacute femoropopliteal artery occlusions were treated with the Rotarex catheter combined with DCB. Lesions were classified according to the onset of symptoms as acutely (< 14 d) or subacutely (14 d to 3 mo) occluded. The mean lesion length was 12.1 cm ± 6.7. The primary endpoint was target lesion patency at 1 year as evaluated by duplex ultrasound (peak systolic velocity ratio < 2.4) and freedom from clinically indicated target lesion revascularization. Amputation rate, major adverse events, and ankle-brachial index at 12 months were evaluated.Results: Technical success rate was 100% (n = 81). Bailout stents were necessary in 14 patients owing to residual stenosis or flow-limiting dissection. Additional thrombolysis was applied in 10 interventions. No major adverse events occurred during hospital stay. There were 9 restenosis cases during the 12-month follow-up period. Primary patency rate was 87.3% (62/71), and freedom from target lesion revascularization rate was 90.1% (64/71). Ankle-brachial index significantly increased from 0.46 ± 0.15 to 0.77 ± 0.14 during follow-up. The amputation rate was 1.4% at 12 months.Conclusions: These initial data from 2 centers suggest that the combination of the Rotarex catheter and DCB may be safe and effective for treatment of acute or subacute thrombotic femoropopliteal occlusion with superior immediate and midterm results achieved. [ABSTRACT FROM AUTHOR]

Abstract Inorganic adsorbents can lower the concentration of phosphate radicals in aqueous solution. However, the traditional adsorbents containing low-valence metal atoms have many defects in the application process, such as low adsorption capacity, easy dissolution in solution, and easy agglomeration of the nano-sized adsorbents and so on. This article presents a novel and effective method to immobilize high-valence Ce element on the porous silica micro-spheres via an impregnation-calcination-activation technique to efficiently remove phosphate radical. The Ce-SiO 2 was synthesized via (1) Ce3+ atoms adsorbed on the surface of silica sphere, (2) cerium nitrate hexahydrate transformed into cerium dioxide via thermal decomposition process and (3) anhydrous cerium dioxide transformed into hydrous cerium oxide (HCO) via an acid activation process. The field-emission scanning electron microscope (FESEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) results indicate that cerium oxide nanoparticles grow homogeneously on the surface of the silica sphere when the heating rate is 2 °C/min at 90.5 °C and 218.0 °C. The X-ray diffraction instrument (XRD) and X-ray photoelectron spectroscopy XPS results demonstrate that Ce3+ atoms could be oxidized into Ce4+ atoms and produce ample reduced ion-exchange sites. Bath adsorption experiments indicate that 15HCO-SiO 2 has excellent properties of removing phosphate ions and the maximum adsorption capacity is 85.5 mg/g. Kinetic and isothermal studies show that the experimental data fit nicely into pseudo-second kinetic and Langmuir models, indicating that the chemical adsorption, as well as the monolayer adsorption, occur simultaneously in the adsorption process. Analysis of the adsorption mechanism analysis suggests that the phosphate ions are sequestered by a reduction and ion-exchange reaction (CeO 2 to CePO 4). Graphical abstract Schematic representation of the synthesis of the adsorbent and phosphate radical adsorption mechanism. Image 1 Highlights • Impregnation-calcination-activation techniques were used to immobilize Ce on the silica-based particles. • Cerium modified adsorbent showed a high phosphate adsorption capacity. • Adsorption performance is evaluate by pseudo-second-oeder kinetic, Webber Morris intra particle diffusion and Langmuir models. • The reduction and ion-exchange from CeO 2 to CePO 4 was occurred in adsorption. [ABSTRACT FROM AUTHOR]

Summary: In order to identify potential biochemical markers that can be used as indicators for phase change, the dynamics of polyphenolic compounds across apple seedlings (Malus domestica, Jonathan×Golden Delicious) were analyzed in this study by high performance liquid chromatography. Precocious flowering was induced by foliar sprays of plant growth regulators. Qualitative changes in the concentration of polyphenols were observed at node nos. 50, 80 and 120. Spontaneous and induced flowering was found at node nos. 122 and 77. It was reasonable to conclude that node no. 77 represented the point of transition between the juvenile phase and the adult vegetative phase, which was marked by the presence of phloridzin in the buds. The disappearance of myricitrin in the bark and the absence of caffeic acid in the aboveground tissues were qualitative markers of the reproductive phase, which was reached at node no. 122. [Copyright &y& Elsevier]