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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.11.040 Byline: Yrtti Valinen (1), Katrin Rapakko (2), Hannaleena Kokkonen (2), Paivi Laitinen (3), Aydin Tekay (1), Tarja Ahola (4), Markku Ryynanen (1) Keywords: Down syndrome; first-trimester trisomy screening; maternal serum screening; prenatal diagnosis Abstract: The purpose of this study was to compare the efficacy of both separate and combined maternal serum testing and fetal nuchal translucency measurement in the first trimester screening for Down syndrome in northern Finland. Author Affiliation: (1) Department of Obstetrics and Gynecology, Department of Oulu University Hospital, Finland (2) Department of Clinical Genetics, Department of Oulu University Hospital, Finland (3) Department of Laboratory, Department of Oulu University Hospital, Finland (4) Department of PerkinElmer, Wallac, Turku, Finland. Article History: Received 5 July 2006; Revised 3 October 2006; Accepted 30 November 2006 Article Note: (footnote) Cite this article as: Valinen Y, Rapakko K, Kokkonen H, et al. Clinical first-trimester routine screening for Down syndrome in singleton pregnancies in northern Finland. Am J Obstet Gynecol 2007;196;278.e1-278.e5.