6 results on '"Kublickas, Marius"'
Search Results
2. A comparison of myogenic and endothelial properties of myometrial and omental resistance vessels in late pregnancy
- Author
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Kublickiene, Karolina-Rasa, Kublickas, Marius, Lindblom, Bo, Lunell, Nils-Olov, and Nisell, Henry
- Subjects
Myometrium -- Physiological aspects ,Vascular resistance -- Measurement ,Pregnancy -- Physiological aspects ,Nitric oxide -- Physiological aspects ,Health - Abstract
Uterine arteries may respond more sensitively to increases in blood pressure than abdominal arteries. Researchers obtained uterine and abdominal arteries from term pregnant women and compared the contraction response of uterine muscle arteries to that of abdominal arteries. Nitric oxide inhibitors did not increase the contraction tone of arteries, suggesting that nitric oxide does not contribute to the contraction response. A drug-induced relaxation response was more pronounced in uterine than abdominal arteries. Uterine arteries may have different contraction and relaxation properties than other arteries.
- Published
- 1997
3. Routine measurements of umbilical artery lactate levels in the prediction of perinatal outcome
- Author
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Westgren, Magnus, Divon, Michael, Horal, Mikalel, Ingemarsson, Ingemar, Kublickas, Marius, Shimojo, Nobuo, and Nordstrom, Lennart
- Subjects
Fetal blood -- Analysis ,Lactic acid -- Measurement ,Health - Abstract
Lactate levels in umbilical cord blood may indicate a lack of oxygen at birth as accurately as acid-base balance but lactate analysis may be easier. Lactate appears in blood when pH is low, as occurs with oxygen deprivation. Researchers analyzed 4,045 umbilical cord blood samples for the presence of lactate using a new electrochemical method that produces a result in one minute. Lactate levels were highest in fetuses that were delivered by cesarean section because of fetal distress. Lactate levels were much higher among vaginal deliveries than among elective cesarean sections. Neither umbilical blood acid-base measurements nor lactate measurements alone may accurately predict the neurologic outcome of newborns. The advantages of lactate analysis are its ease of use and low cost.
- Published
- 1995
4. OP 6 The association between pre-eclampsia and the risk of kidney disease – A nationwide cohort study
- Author
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Khashan, Ali, Kublickas, Marius, Kenny, Louise, and Kublickiene, Karolina
- Published
- 2017
- Full Text
- View/download PDF
5. Pregnancy outcomes in women with chronic kidney disease and chronic hypertension: a National cohort study.
- Author
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Al Khalaf, Sukainah Y., O'Reilly, Éilis J., McCarthy, Fergus P., Kublickas, Marius, Kublickiene, Karolina, and Khashan, Ali S.
- Subjects
CHRONIC kidney failure ,PREGNANCY outcomes ,SMALL for gestational age ,HYPERTENSION ,CESAREAN section ,HYPERTENSION epidemiology ,RESEARCH ,PREMATURE infants ,RESEARCH methodology ,ACQUISITION of data ,MEDICAL cooperation ,EVALUATION research ,PREECLAMPSIA ,PERINATAL death ,COMPARATIVE studies ,PREGNANCY complications ,LONGITUDINAL method - Abstract
Background: Maternal chronic kidney disease and chronic hypertension have been linked with adverse pregnancy outcomes. We aimed to examine the association between these conditions and adverse pregnancy outcomes over the last 3 decades.Objective: We conducted this national cohort study to assess the association between maternal chronic disease (CH, CKD or both conditions) and adverse pregnancy outcomes with an emphasis on the effect of parity, maternal age, and BMI on these associations over the last three decades. We further investigated whether different subtypes of CKD had differing effects.Study Design: We used data from the Swedish Medical Birth Register, including 2,788,490 singleton births between 1982 and 2012. Women with chronic kidney disease and chronic hypertension were identified from the Medical Birth Register and National Patient Register. Logistic regression models were performed to assess the associations between maternal chronic disease (chronic hypertension, chronic kidney disease, or both conditions) and pregnancy outcomes, including preeclampsia, in-labor and prelabor cesarean delivery, preterm birth, small for gestational age, and stillbirth.Results: During the 30-year study period, 22,397 babies (0.8%) were born to women with chronic kidney disease, 13,279 (0.48%) to women with chronic hypertension and 1079 (0.04%) to women with both conditions. Associations with chronic hypertension were strongest for preeclampsia (adjusted odds ratio, 4.57; 95% confidence interval, 4.33-4.84) and stillbirth (adjusted odds ratio, 1.65; 95% confidence interval, 1.35-2.03) and weakest for spontaneous preterm birth (adjusted odds ratio, 1.07; 95% confidence interval, 0.96-1.20). The effect of chronic kidney disease varied from (adjusted odds ratio, 2.05; 95% confidence interval, 1.92-2.19) for indicated preterm birth to no effect for stillbirth (adjusted odds ratio, 1.16; 95% confidence interval, 0.95-1.43). Women with both conditions had the strongest associations for in-labor cesarean delivery (adjusted odds ratio, 1.86; 95% confidence interval, 1.49-2.32), prelabor cesarean delivery (adjusted odds ratio, 2.68; 95% confidence interval, 2.18-3.28), indicated preterm birth (adjusted odds ratio, 9.09; 95% confidence interval, 7.61-10.7), and small for gestational age (adjusted odds ratio, 4.52; 95% confidence interval, 3.68-5.57). The results remained constant over the last 3 decades. Stratified analyses of the associations by parity, maternal age, and body mass index showed that adverse outcomes remained independently higher in women with these conditions, with worse outcomes in multiparous women. All chronic kidney disease subtypes were associated with higher odds of preeclampsia, in-labor cesarean delivery, and medically indicated preterm birth. Different subtypes of chronic kidney disease had differing risks; strongest associations of preeclampsia (adjusted odds ratio, 3.98; 95% confidence interval, 2.98-5.31) and stillbirth (adjusted odds ratio, 2.73; 95% confidence interval, 1.13-6.59) were observed in women with congenital kidney disease, whereas women with diabetic nephropathy had the most pronounced increase odds of in-labor cesarean delivery (adjusted odds ratio, 3.54; 95% confidence interval, 2.06-6.09), prelabor cesarean delivery (adjusted odds ratio, 7.50; 95% confidence interval, 4.74-11.9), and small for gestational age (adjusted odds ratio, 4.50; 95% confidence interval, 2.92-6.94). In addition, women with renovascular disease had the highest increased risk of preterm birth in both spontaneous preterm birth (adjusted odds ratio, 3.01; 95% confidence interval, 1.57-5.76) and indicated preterm birth (adjusted odds ratio, 8.09; 95% confidence interval, 5.73-11.4).Conclusion: Women with chronic hypertension, chronic kidney disease, or both conditions are at an increased risk of adverse pregnancy outcomes which were independent of maternal age, body mass index, and parity. Multidisciplinary management should be provided with intensive clinical follow-up to support these women during pregnancy, particularly multiparous women. Further research is needed to evaluate the effect of disease severity on adverse pregnancy outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
6. Stillbirth is associated with increased risk of long-term maternal renal disease: a nationwide cohort study.
- Author
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Barrett, Peter M., McCarthy, Fergus P., Evans, Marie, Kublickas, Marius, Perry, Ivan J., Stenvinkel, Peter, Khashan, Ali S., and Kublickiene, Karolina
- Subjects
STILLBIRTH ,KIDNEY diseases ,CHRONIC kidney failure ,PROPORTIONAL hazards models ,BODY mass index ,MATERNAL age ,RESEARCH ,RESEARCH methodology ,ACQUISITION of data ,EVALUATION research ,MEDICAL cooperation ,PUERPERAL disorders ,PERINATAL death ,COMPARATIVE studies ,LONGITUDINAL method - Abstract
Background: Stillbirth is a devastating adverse pregnancy outcome that may occur without any obvious reason or may occur in the context of fetal growth restriction, preeclampsia, or other obstetric complications. There is increasing evidence that women who experience stillbirths are at greater risk of long-term cardiovascular disease, but little is known about their risk of chronic kidney disease and end-stage renal disease. We conducted the largest study to date to investigate the subsequent risk of maternal chronic kidney disease and end-stage renal disease following stillbirth.Objective: To identify whether pregnancy complicated by stillbirth is associated with subsequent risk of maternal chronic kidney disease and end-stage renal disease, independent of underlying medical or obstetric comorbidities.Study Design/methods: We conducted a population-based cohort study using nationwide data from the Swedish Medical Birth Register, National Patient Register, and Swedish Renal Register. We included all women who had live births and stillbirths from 1973 to 2012, with follow-up to 2013. Women with preexisting renal disease were excluded. Cox proportional hazard regression models were used to estimate adjusted hazard ratios and 95% confidence intervals for associations between stillbirth and maternal chronic kidney disease and end-stage renal disease respectively. We controlled for maternal age, year of delivery, country of origin, parity, body mass index, smoking, gestational diabetes, preeclampsia, and small for gestational age deliveries. Women who had a history of medical comorbidities, which may predispose to renal disease (prepregnancy cardiovascular disease, hypertension, diabetes, lupus, systemic sclerosis, hemoglobinopathy, or coagulopathy), were excluded from the main analysis and examined separately.Results: There were 1,941,057 unique women who had 3,755,444 singleton pregnancies, followed up over 42,313,758 person-years. The median follow-up time was 20.7 years (interquartile range, 9.9-30.0 years). 13,032 women (0.7%) had at least 1 stillbirth. Women who had experienced at least 1 stillbirth had a greater risk of developing chronic kidney disease (adjusted hazard ratio, 1.26; 95% confidence interval, 1.09-1.45) and end-stage renal disease (adjusted hazard ratio, 2.25; 95% confidence interval, 1.55-3.25) compared with women who only had live births. These associations persisted after removing all stillbirths that occurred in the context of preeclampsia, and small for gestational age or congenital malformations (for chronic kidney disease, adjusted hazard ratio, 1.33; 95% confidence interval, 1.13-1.57; for end-stage renal disease, adjusted hazard ratio, 2.95; 95% confidence interval, CI 1.86-4.68). There was no significant association observed between stillbirth and either chronic kidney disease or end-stage renal disease in women who had preexisting medical comorbidities (chronic kidney disease, adjusted hazard ratio, 1.13; 95% confidence interval, 0.73-1.75 or end-stage renal disease, adjusted hazard ratio, 1.49; 95% confidence interval, 0.78-2.85).Conclusion: Women who have a history of stillbirth may be at increased risk of chronic kidney disease and end-stage renal disease compared with women who have only had live births. This association persists independently of preeclampsia, and small for gestational age, maternal smoking, obesity, and medical comorbidities. Further research is required to determine whether affected women would benefit from closer surveillance and follow-up for future renal disease. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
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