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[Display omitted] • Office building energy consumption across all ASHRAE climate zones in the U.S. were simulated. • Impact of different south façade PV-louver typologies on building energy consumption were assessed. • Different typologies of PV-louvers and roof mounted PV potential electricity were calculated. • Occupants visual comfort was assessed by DA index, mean illuminance levels and GDP. Integrating PV panels into building facades (BIPV) necessitates a comprehensive understanding of the PV system's impact on building energy consumption within the site's climate zone. Maximizing PV power output depends on factors such as location, climate type, and latitude. However, minimizing total electricity consumption, which includes cooling, heating, and lighting loads, is significantly influenced by the design of the PV system and the climate region. This study conducted a thorough evaluation of the impact of south-facing PV-integrated louvers on both PV power generation and building energy performance, as well as occupants' visual comfort, across 17 ASHRAE climate regions in the U.S. The results indicated that south-facing PV-integrated louvers significantly reduced building energy consumption in climate zones 1 to 3, as well as 4B and 5B. Wider louvers with longer spacing (S-3 typology) were particularly effective in zones with moderate cooling needs (climate zone 4). However, in colder climates (6–8) with significant heating demands, roof-mounted systems provided a better balance between power generation and solar heat gain for the building. The PV-louver designs effectively reduced sunlight penetration and maintained illuminance levels within the desired range across most of the floor area. Conversely, roof typologies exhibited lower lighting loads but resulted in significantly high mean illuminance levels on the working surface, leading to disturbing glare for occupants across a large portion of the floor area. The findings of this research offer practical implications for architects, engineers, and policymakers seeking sustainable building solutions. [ABSTRACT FROM AUTHOR]

Abstract: High performance glass such as low-e coated or heat reflective glass offers better thermal performance, preventing undesired heat loss or gain during a building operation phase. However, these coatings may not be as effective in certain climate zones and create glare problems for adjacent buildings. A transparent composite façade system (TCFS) was newly configured to provide a sustainable alternative to a high performance glass wall in that the biofiber composite core acts as a shading device while the airspace between the polymer skins provides adequate insulation. A comparative life cycle assessment (LCA) method was selected as a sustainability measuring tool to compare the environmental impacts of a TCFS with a glass curtain wall system (GCWS). In this paper, the environmental performance of a façade system is characterized by the energy consumption and CO2 emissions through all stages of the life cycle. Comparative LCA results show that the total life cycle energy of the TCFS is estimated to be 93% of that of the uncoated GCWS, and the total emissions of kg CO2 equivalent for the TCFS is determined to be 89% of the uncoated GCWS. The use phase for both the TCFS and GCWS plays a dominant role in reducing environmental impacts while the impact associated with transportation and the end-of-life management is estimated to be insignificant in this study. The life cycle inventory data and analysis results provided in this paper are expected to assist designers with a better understanding of building material selection and system improvement from the whole life cycle perspectives. [Copyright &y& Elsevier]

Abstract: The effect of gamma irradiation (0.5–2kGy) on the physicochemical properties of peaches was investigated during a 6-day storage at 20±3°C. Gamma irradiation is able to inactivate the four pathogens, namely Botrytis cinerea, Penicillium expansum, Rhizopus stolonifer var. stolonifer and Monilinia fructicola in peaches. Hardness significantly decreased with the increment of irradiation dose level whereas soluble solid and total polyphenol contents increased with increment of irradiation dose level. 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity of the irradiated peach was higher than that of control, and its activity increased with increment of irradiation dose level. These results suggest that gamma irradiation of peaches improved antioxidant activity, but dramatically affects the hardness throughout the entire storage time. [Copyright &y& Elsevier]

Abstract: Ionizing radiation is able to inactivate the three pathogens of Botrytis cinerea, Diaporthe actinidiae, and Botryosphaeria dothidea in kiwifruit. Irradiated kiwifruits appeared softer compared to non-irradiated kiwifruits. The color and organic acid content of kiwifruits were minimally affected by the irradiation. Irradiated fruits showed a decrease in the total soluble solids content with increasing irradiation dose. Irradiation of kiwifruit up to 3kGy had negative effects on vitamin C content and antioxidant activity, but it contributed to improving sensory quality. [Copyright &y& Elsevier]

Abstract: The metabolomic analysis of various types of deer antler was performed by 1H NMR spectrometry and principal components analysis (PCA). The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal components (PC1, PC2, and PC3), which cumulatively accounted for 93.5% of the variation in all variables. In particular, the score plots by the combination of PC1 and PC3 allowed an excellent separation of the antler samples. In addition, the major peaks in 1H NMR spectra contributing to the discrimination were assigned to lactate, alanine, acetic acid, choline, glycine, valine, tyrosine, and phenylalanine. This metabolomic-analysis-based method allows various types of deer antler to be efficiently differentiated without any pre-purification steps. [Copyright &y& Elsevier]

Abstract: A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities. [Copyright &y& Elsevier]

A platinum electrocatalyst was presented for oxygen reduction reaction that the durability to potential cycling was enhanced. It was synthesized by coating carbon black with a silica layer, followed by Pt deposition on it. To investigate the durability of the electrocatalyst, two accelerated degradation testing protocols were carried out. Carbon corrosion and platinum metal degradation properties were evaluated under the potential cycling between 1.0 and 1.5 V and between 0.6 and 0.95 V, respectively. Silica-coated catalysts (Pt/CB-SiO 2) showed better stabilities compared to the commercial Pt/C catalyst under both of the two protocols. Commercial Pt/C catalyst initially had better mass activity than silica-coated catalysts but it became similar after the potential cycling of carbon corrosion. TEM showed the platinum particle aggregation and particle density decrease especially for the commercial catalyst by the potential cycling. The silica coating prevents carbon corrosion by blocking the carbon support from direct contact with the oxygen source and preventing the effect of oxygen spillover from the platinum to carbon during the potential cycling between 1.0 and 1.5 V. It also alleviates platinum dissolution in reverse scans by reducing the formation of Pt oxide during potential cycling in between 0.6 and 0.95 V. The results suggest the coating of carbon support can enhance the durability of Pt/C catalyst to the potential cycling. • Carbon black was successfully coated with silica. • Platinum was deposited preferentially on the silica over the carbon black surface. • The silica coating improved the durability of Pt/C under two types of ADT. • Silica coating counteracted the effect of the oxygen spillover from Pt to carbon. • Silica coating shifted Pt oxidation potential to the higher value. [ABSTRACT FROM AUTHOR]

Abstract: A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines. [Copyright &y& Elsevier]

Abstract: Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13nM in PPARα and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model. [Copyright &y& Elsevier]

Abstract: Synthesis of a novel series of DPPIV inhibitors with 1,2,4- and 1,3,4-oxadiazolyl ketone derivatives and its structure–activity relationships are discussed. Compound 18h showed good inhibitory activity against DPPIV and favorable pharmacokinetic properties. In vivo pharmacodynamic efficacy and co-crystal structure of compound 18h with DPPIV is also described. [Copyright &y& Elsevier]

Abstract: A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells. [Copyright &y& Elsevier]

Abstract: 1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. [Copyright &y& Elsevier]