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A novel cotton/Ni/Co-Ni layered double hydroxide (CT/Ni/Co-Ni LDH) hybrid yarn electrode material is prepared by constructing a three-dimensional (3D) metallic Ni conductive network on the cotton fiber surface for rapid electron transportation and subsequently in situ growing Co-Ni LDH nanosheet array layers with high electroactive surface area for faradic reactions. The 3D porous electrode structure facilitates the effective electrolyte ion diffusion. The obtained yarn electrode material shows a high areal capacitance of 1.26 F/cm 2 (121571.1 C/cm 2 ) at a scan rate of 5 mV/s, as well as a stable electrochemical performance under various mechanical deformations. An all-solid-state yarn supercapacitor device is further assembled based on the obtained yarn electrode materials, which exhibits a high energy density of 9.3 μWh/cm 2 at a power density of 43.99 μW/cm 2 . [ABSTRACT FROM AUTHOR]

A high-performance yarn electrode material, cotton/graphene/polyaniline, is synthesized by coating primary fiber cores inside cotton yarns with graphene sheets and followed by further growing polyaniline nanowire array layers through in situ polymerization of aniline. The electron transportation is enhanced by the 3D graphene conductive network on cotton fibers, which further bridges the polyaniline nanowires. The polyaniline nanowires with small diameters ensure high electrochemically active surface area. The spaces within the polyaniline nanowire array layers and the hierarchical pores of the entire yarn electrode benefit the fast electrolyte ion diffusion. The unique 3D yarn electrode structure results in an excellent electrochemical performance. The maximum areal capacitance and capacitance retention are 246 mF/cm 2 at 5 mV/s and 98% after 3800 cycles, respectively. A symmetric all-solid-state yarn supercapacitor is fabricated by using this yarn electrode, which delivers an energy density of 9.7 μWh/cm 2 at a power density of 840.9 μW/cm 2 . [ABSTRACT FROM AUTHOR]

Aims To investigate the antitumor effects of 7- O -geranylquercetin (GQ), a novel O -alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms. Main methods Cell viability was assessed using MTT assay. The expression of proteins involved in apoptosis and autophagy was measured using western blotting. Besides, apoptosis was determined with DAPI staining, Annexin V-PI staining and transmission electron microscopy (TEM) assay, and autophagy was observed with TEM assay. Cell cycle and reactive oxygen species (ROS) level were detected using flow cytometry. Key findings GQ inhibited viability of A549 and NCI-H1975 cells in a dose- and time-dependent manner without apparent cytotoxicity to normal human lung fibroblast cells. GQ down-regulated the expression of apoptosis-related proteins pro-caspase 3 and Bcl-2, and up-regulated the expression of cleaved-PARP and Bax in A549 and NCI-H1975 cells. Meanwhile, GQ-induced cell apoptosis could be attenuated by caspase inhibitor Z-VAD-FMK. Besides, GQ induced autophagosome formation in A549 and NCI-H1975 cells, promoted the expression of autophagy-related proteins LC3-II and Beclin 1, and suppressed the expression of p62. Autophagy inhibition with chloroquine or Beclin 1 siRNA could effectively inhibit GQ-induced apoptosis. Furthermore, GQ treatment increased the generation of ROS, and ROS inhibitor N -acetylcysteine could reverse GQ-induced autophagy and apoptosis. Taken together, GQ could induce apoptosis and autophagy via ROS generation in A549 and NCI-H1975 cells, and GQ-induced autophagy contributed to apoptosis. Significance Our findings highlight that GQ is a promising anticancer agent for the treatment of lung cancer. [ABSTRACT FROM AUTHOR]