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Start Over Author "Kaneko, K" Publisher elsevier b.v.
315 results on '"Kaneko, K"'

26. Different changes in the biomarker C-terminal telopeptides of type II collagen (CTX-II) following intra-articular injection of high molecular weight hyaluronic acid and oral non-steroidal anti-inflammatory drugs in patients with knee osteoarthritis: a...

Author

Ishijima, M., Nakamura, T., Shimizu, K., Hayashi, K., Kikuchi, H., Soen, S., Omori, G., Yamashita, T., Uchio, Y., Chiba, J., Ideno, Y., Kubota, M., Kaneko, H., Kurosawa, H., Kaneko, K., and Research Group of Cartilage Metabolism

Abstract

Objectives: We previously reported, based on a multicenter randomized-control study, that the efficacy of intra-articular injections of hyaluronic acid (IA-HA) was not inferior to that of oral non-steroidal anti-inflammatory drugs (NSAIDs) in patients with knee osteoarthritis (OA). However, the molecular effects on the pathophysiology of knee OA remain unclear. C-terminal telopeptides of type II collagen (CTX-II) is reported to primarily originate from the interface between articular cartilage and subchondral bone, which is a site of potential remodeling in OA. We performed a predefined sub-analysis of the previous study to compare the changes of urinary CTX-II (uCTX-II) in response to IA-HA to those in response to NSAID for knee OA.Design: A total of 200 knee OA patients were registered from 20 hospitals and randomized to receive IA-HA (2,700 kDa HA, 5 times at 1-week intervals) or NSAID (loxoprofen sodium, 180 mg/day) for 5 weeks. The uCTX-II levels were measured before and after treatment.Results: The uCTX-II levels were significantly increased by IA-HA treatment (337.7 ± 193.8 to 370.7 ± 234.8 ng/μmol Cr) and were significantly reduced by NSAID treatment (423.2 ± 257.6 to 370.3 ± 250.9 ng/μmol Cr). The %changes of uCTX-II induced by IA-HA (11.6 ± 29.5%) and NSAID (-9.0 ± 26.7%) was significantly different (between-group difference: 20.6, 95% confidence intervals: 10.6 to 30.6).Conclusions: While both IA-HA and NSAID improved symptoms of knee OA, uCTX-II levels were increased by IA-HA and reduced by NSAIDs treatment, suggesting these treatments may improve symptoms of knee OA through different modes of action. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Complex dynamical behaviour in economic production networks

Author

Ponzi, A., Yasutomi, A., and Kaneko, K.

Subjects
Business, Economics
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jebo.2004.07.013 Byline: A. Ponzi (a), A. Yasutomi (b), K. Kaneko (a) Keywords: Economic production network; von Neumann's static model; Production process Abstract: A dynamical model of an economic production network is proposed as an extension of von Neumann's static model. Sets of input commodities are jointly converted into sets of output commodities by production processes. The rate of production of a given production process is limited by the minimum quantity of its set of input commodities. It is shown that economic production is autonomously sustained, without price divergence, even without the imposition of any external constraints on price determination. This is accomplished through switching between different choices of the minimum input commodity, which leads to the appearance of complex cyclic behaviour. The mechanism and origin of this oscillation is analysed in depth. The generation of complex oscillations with multiple timescales is also shown when several processes are combined to form a chain or a network. Author Affiliation: (a) Department of Pure and Applied Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153, Japan (b) Interfaculty Initiative in Information Studies, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan Article History: Received 26 October 2003; Accepted 21 July 2004

Published
2006

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