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Highlights: [•] Debris filtering efficiencies for two debris filter designs used in PWRs are provided. [•] Various debris used in the tests are selected to simulate actual debris found in PWRs. [•] Debris filter efficiency is explained by flow-hole size and grid strap height. [•] The effect of debris filters on flow blockage during LTC after a LOCA is described. [Copyright &y& Elsevier]

Abstract: The nanoporous alumina membranes (NAMs) were fabricated by a two-step aluminium anodic oxidation process. The fabricated NAMs have controllable pore diameters (40–80nm) and unidirectionally ordered pore direction. The surface of the NAM was modified with the organo-silane agent (APTES: (aminopropyl)triethoxysilane) to induce ionic bonding between the NAM and the photosensitizer (TSPP: tetrakis(p-sulfonatophenyl)porphyrin). The morphology and chemical nature of the surface modified NAM were studied by field emission scanning electron microscope (FE-SEM), FT-IR spectra, and thermo gravimetric analysis (TGA). Furthermore, this singlet oxygen generating nanoporous membranes (SGNMs) were investigated, in detail, to understand their photophysical properties and the singlet oxygen generation efficiency which were the essential factors for their applications. Steady-state spectroscopies and nanosecond laser induced time-resolved spectroscopy were applied to get information on all photophysical properties including the lifetime of singlet oxygen which depended on the pore diameter of the SGNM. [Copyright &y& Elsevier]

Abstract: Individuals with Down syndrome (DS) suffer from mental retardation. Overexpression and the resulting increased specific activity of Dyrk1A kinase located on chromosome 21 cause a learning and memory deficit in Dyrk1A transgenic mice. To search for therapeutic agents with Dyrk1A inhibition activity, previously we obtained HCD160 as a new hit compound for Dyrk1A inhibition. In the present study, we synthesized 34 HCD160 derivatives to investigate the quantitative structure–activity relationship (QSAR). This analysis could provide important information for novel drug discovery for treatment of DS related learning and memory deficits. [Copyright &y& Elsevier]