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322 results on '"Johnson, Daniel"'

11. The economic well-being of nations is associated with positive daily situational experiences

Author

Beramendi, Maite, Bastian, Brock, Neubauer, Aljoscha, Cortez, Diego, Roth, Eric, Torres, Ana, Zanini, Daniela S., Petkova, Kristina, Tracy, Jessica, Amiot, Catherine, Pelletier-Dumas, Mathieu, González, Roberto, Rosenbluth, Ana, Salgado, Sergio, Guan, Yanjun, Yang, Yu, Forero, Diego, Camargo, Andrés, Papastefanakis, Emmanouil, Kritsotakis, Georgios, Spyridaki, Eirini, Fragkiadaki, Evangelia, Jerneić, Željko, Hřebíčková, Martina, Graf, Sylvie, Strøbæk, Pernille, Realo, Anu, Becker, Maja, Maisonneuve, Christelle, El-Astal, Sofian, Gamsakhurdia, Vladimer Lado, Rauthmann, John, Ziegler, Matthias, Penke, Lars, Buchtel, Emma E., Yeung, Victoria Wai-Lan, Kun, Ágota, Gadanecz, Peter, Vass, Zoltán, Smohai, Máté, Lavalekar, Anagha, Aurelia, Meta Zahro, Kinayung, Dian, Gaffar, Vanessa, Sullivan, Gavin, Day, Christopher, Rechter, Eyal, Perugini, Marco, Costantini, Giulio, Gnisci, Augusto, Sergi, Ida, Senese, Vincenzo Paolo, Mottola, Francesca, Sato, Tatsuya, Nakata, Yuki, Kawamoto, Shizuka, Komiya, Asuka, Al-Zoubi, Marwan, Owsley, Nicholas, Jang, Chaning, Mburu, Georgina, Ngina, Irene, Dimdins, Girts, Barkauskiene, Rasa, Laurinavicius, Alfredas, Markovikj, Marijana, Serafimovska, Eleonara, Mastor, Khairul A., Kruse, Elliott, Ramírez-Esparza, Nairán, Denissen, Jaap, Van Aken, Marcel, Fischer, Ron, Onyishi, Ike E., Ogba, Kalu T., Leknes, Siri, Holen, Vera Waldal, Hansen, Ingelin, Tamnes, Christian Krog, Klæva, Kaia, Kausar, Rukhsana, Khan, Nashi, Rizwan, Muhammad, Espinosa, Agustín, Gastardo-Conaco, Maria Cecilia, Quiñones, Diwa Malaya A., Izdebski, Paweł, Kotyśko, Martyna, Szarota, Piotr, Henriques-Calado, Joana, Sava, Florin Alin, Lvova, Olya, Pogrebitskaya, Victoria, Allakhverdov, Mikhail, Manichev, Sergey, Barry, Oumar, Smederevac, Snežana, Čolović, Petar, Mitrović, Dušanka, Oljača, Milan, Hong, Ryan, Halama, Peter, Musek, Janek, De Kock, Francois, Han, Gyuseog, Suh, Eunkook M., Choi, Soyeon, Gallardo-Pujol, David, Oceja, Luis, Villar, Sergio, Kekecs, Zoltan, Arlinghaus, Nils, Johnson, Daniel P., O'Donnell, Alice Kathryn, Kulich, Clara, Lorenzi-Cioldi, Fabio, Bühler, Janina Larissa, Allemand, Mathias, Chang, Yen-Ping, Lin, Wei-fang, Boonyasiriwat, Watcharaporn, Saribay, S. Adil, Somer, Oya, Akalin, Pelin Karakus, Baguma, Peter Kakubeire, Vinogradov, Alexander, Zhuravlova, Larisa, Conner, Mark, Rentfrow, Jason, Tullett, Alexa, Sauerberger, Kyle, Colman, Douglas E., Cheng, Joey T., Stocks, Eric, Thi Thu Bui, Huyen, Gardiner, Gwendolyn, Lee, Daniel I., Baranski, Erica, and Funder, David C.

Published
2023
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20. Ccr4-not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy.

Author

Johnson, Daniel L., Kumar, Ravinder, Kakhniashvili, David, Pfeffer, Lawrence M., and Laribee, R. Nicholas

Subjects
*PROTEOMICS, *RIBOSOMAL proteins, *BIOCHEMICAL substrates, *GENETIC transcription, *GENETIC translation
Abstract

The Ccr4-Not complex contains the poorly understood Not4 ubiquitin ligase that functions in transcription, mRNA decay, translation, proteostasis, and endolysosomal nutrient signaling. To gain further insight into the in vivo functions of the ligase, we performed quantitative proteomics in Saccharomyces cerevisiae using yeast cells lacking Not4, or cells overexpressing wild-type Not4 or an inactive Not4 mutant. Herein, we provide evidence that balanced Not4 activity maintains ribosomal protein (RP) homeostasis independent of changes to RP mRNA or known Not4 ribosomal substrates. Intriguingly, we also find that Not4 loss activates 40S ribosomal autophagy independently of canonical Atg7-dependent macroautophagy, indicating that microautophagy is responsible. We previously demonstrated that Ccr4-Not stimulates the target of rapamycin complex 1 (TORC1) signaling, which activates RP expression and inhibits autophagy, by maintaining vacuole V-ATPase H+ pump activity. Importantly, combining Not4 deficient cells with a mutant that blocks vacuole H+ export fully restores RP expression and increases 40S RP autophagy efficiency. In contrast, restoring TORC1 activity alone fails to rescue either process, indicating that Not4 loss disrupts additional endolysosomal functions that regulate RP expression and 40S autophagy. Analysis of the Not4-regulated proteome reveals increases in endolysosomal and autophagy-related factors that functionally interact with Not4 to control RP expression and affect 40S autophagy. Collectively, our data indicate that balanced Ccr4-Not ubiquitin ligase signaling maintains RP homeostasis and inhibits 40S autophagy via the ligase’s emerging role as an endolysosomal regulator. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Supporting Emergency Medical Services Clinicians Through Acute and Sustained Crises With Informal Peer Support and Intentional Acts of Kindness: The Emergency Medical Services Code Lavender Program.

Author

Maloney, Lauren M., Hoffman, Jason, Peralta, Edder, Princi, Rudolph, Thode, Henry C., Tomlin, Mark, DiDonato, Christopher, LaBarbera, Anthony, Lambert, Erin, King, James, Johnson, Daniel G., Edouard, Shawn, and Williams, Sarah

Abstract

Given the recommendations against the use of critical incident stress debriefing, the emergency medical services (EMS) Code Lavender program was created as a mechanism to consistently recognize and reach out to EMS clinicians after acute crisis events, offer nonintrusive informal peer support and acts of kindness, and provide stepwise support via mental health professionals as needed. The study aimed to assess program utilization and evaluate the program's impact on EMS clinicians' perceptions of support and resources available to them after an acute crisis event. Anonymous surveys were distributed before program implementation and 18 months later. Program utilization was tracked using REDCap (Vanderbilt University, Nashville, TN). Fisher exact tests and logistic regression were used to analyze the survey results. Within 30 months, 87 referrals were made. Seventy-seven preprogram (59% response rate) and 104 intraprogram (88% response rate) surveys were collected. There were no differences between respondents by sex or role. There were significant improvements in knowing where to go for help (from 40% to 85%, P <.001) and willingness to seek help if needed (from 40% to 59%, P =.02). The implementation of an EMS Code Lavender program led to significant increases in EMS clinician self-reported knowledge of where to go and willingness to seek help after acute crisis events. [ABSTRACT FROM AUTHOR]

Published
2024
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