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Start Over Author "Jie Hua" Publisher elsevier b.v.
222 results on '"Jie Hua"'

27. The impact of medium-chain triglycerides on weight loss and metabolic health in individuals with overweight or obesity: A systematic review and meta-analysis.

Author

He, Hui, Liu, Kang, Liu, Min, Yang, Ai-Jia, Cheng, Ka-Wing, Lu, Louise Weiwei, Liu, Bin, and Chen, Jie-Hua

Abstract

The efficacy of medium-chain triglycerides (MCTs) for weight management and mitigating metabolic disorders among individuals with overweight and obesity remains a topic of ongoing discussion. Notably, there is a gap in the distinction between pure MCTs and medium-long-chain triglycerides (MLCTs). This meta-analysis investigates the efficacy of MCTs on weight loss and glucolipid metabolism in these populations, explicitly evaluating the differential effects of pure MCTs and MLCTs. We performed a random-effects meta-analysis on relevant studies examining weight loss and glucolipid parameters, incorporating a subgroup analysis conducted based on intervention types, pure MCTs versus MLCTs. Our findings revealed diets enriched with MCTs are more effective in achieving weight reduction (WMD: −1.53%; 95% CI: −2.44, −0.63; p < 0.01), particularly those containing pure MCTs (WMD: −1.62%; 95% CI: −2.78, −0.46; p < 0.01), compared to long-chain fatty acids (LCTs) enriched diets. However, our subgroup analysis indicates that an MLCTs-enriched diet did not significantly reduce weight loss. Additionally, MCTs-enriched diets were associated with significant reductions in blood triglyceride levels and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores, compared to LCTs-enriched diets. Hence, the authors recommend incorporating pure MCTs in dietary interventions for individuals with overweight and obesity, particularly those with comorbidities such as dyslipidemia and impaired glucose metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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48. O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression.

Author

Jianxin Zhao, Jie Hua, Yahui Zhan, Chunxu Chen, Yue Liu, Liqian Yang, Haiying Wang, Hengbin Wang, and Jing Li

Subjects
*CELL cycle, *DEUBIQUITINATING enzymes, *CHROMOSOME segregation, *GENETIC regulation, *PROTEIN folding, *PEPTIDASE
Abstract

Histone 2A monoubiquitination (uH2A) underscores a key epigenetic regulation of gene expression. In this report, we show that the deubiquitinase for uH2A, ubiquitin-specific peptidase 16 (USP16), is modified by O-linked N-acetylglucosamine (OGlcNAc). O-GlcNAcylation involves the installation of the OGlcNAc moiety to Ser/Thr residues. It crosstalks with Ser/Thr phosphorylation, affects protein--protein interaction, alters enzyme activity or protein folding, and changes protein subcellular localization. In our study, we first confirmed that USP16 is glycosylated on Thr203 and Ser214, as reported in a previous chemoenzymatic screen. We then discovered that mutation of the O-GlcNAcylation site Thr203, which is adjacent to deubiquitination-required Cys204, reduces the deubiquitination activity toward H2AK119ub in vitro and in cells, while mutation on Ser214 had the opposite effects. Using USP16 Ser552 phosphorylation-specific antibodies, we demonstrated that O-GlcNAcylation antagonizes cyclin-dependent kinase 1--mediated phosphorylation and promotes USP16 nuclear export. O-GlcNAcylation of USP16 is also required for deubiquitination of Polo-like kinase 1, a mitotic master kinase, and the subsequent chromosome segregation and cytokinesis. In summary, our study revealed that O-GlcNAcylation of USP16 at Thr203 and Ser214 coordinates deubiquitination of uH2A and Polo-like kinase 1, thus ensuring proper cell cycle progression. [ABSTRACT FROM AUTHOR]

Published
2024
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