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[Display omitted] • Four new compounds were isolated from the fruits of Nicandra physaloides. • Seventeen known compounds were isolated from the genus Physalis for the first time. • Four compounds were showed strong anti-inflammatory activities. Twenty-one compounds were isolated and identified from the ethanol extract of the fruits of Nicandra physaloides , including four new (1 – 4) and 17 known compounds (5 – 21). All the compounds were isolated from the genus Physalis for the first time. In this study, NMR spectroscopy was used to study the compound structures by comparing their data with those reported in the literature. Moreover, the potential anti-inflammatory activity of RAW264.7 cells induced by lipopolysaccharide (LPS) was evaluated. Among the monoterpenoids, compounds (5–7 , 9) exhibited weak anti-inflammatory activities, with IC 50 values ranging from 29.10 to 68.30 μM. [ABSTRACT FROM AUTHOR]

Six undescribed compounds, including three phenolic glycosides (1 – 3) and three indole alkaloids (4 – 6), together with ten known alkaloids (7 – 16) and three known phenolic glycosides (17 – 19), were isolated from 70% EtOH aqueous extracts of the roots and rhizomes of Clematis chinensis Osbeck. The structures were elucidated by NMR, HRESIMS and X-ray diffraction spectroscopies. The anti-inflammatory activity of these compounds was evaluated, and twelve compounds showed significant inhibitory activity against TNF-α with an inhibition ratio from 47.87% to 94.70% at a dose of 10 μM. Compound 7 exhibited significant inhibitory activity against TNF-α and IL-6 with IC 50 values of 3.99 μM and 2.24 μM, respectively. Compound 8 displayed potent anti-inflammatory activity against mouse ear edema induced by croton oil. A mechanistic study suggested that compounds 7 and 8 decreased the activation of the NF-κB signaling pathway to reduce the secretion of inflammatory factors in LPS-induced RAW 264.7 cells. Six undescribed compounds together with thirteen known ones were isolated from Clematis chinensis. Mechanistic study suggested that compounds 7 and 8 could decrease the activation of NF-κB signaling pathway. [Display omitted] • Six undescribed compounds were isolated from the Clematis chinensis. • Twelve compounds showed inhibitory activity against TNF-α. • Three compounds exhibited potent inhibitory activity on NO. • Compounds 7 and 8 could decrease the activation of NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

Four new indole alkaloids, daturametelindoles A-D (1–4) were isolated from the EtOAc soluble partition of the ethanol extract of the Datura metel seeds. The structures of the new compounds were determined based on spectroscopic evidence, including their 1D- and 2D-NMR spectra and mass spectrometry. In particular, compounds 1–4 were all racemes, confirmed by the optical rotations and CD spectra. Unfortunately, the chiral monomers were not obtained due to the amount, but the developments of their chiral separation and chiral resolution were completed. All isolated compounds were evaluated for cytotoxic effects against human gastric adenocarcinoma cells (SGC-7901), human hepatoma (Hepg2), and human breast cancer (MCF-7). Unlabelled Image [ABSTRACT FROM AUTHOR]