Search

Abstract: The goal of the present research is to investigate the temporal dynamics of brain regions involved in processing emotional words in a sentence context. Both behavioral and ERP data were acquired while participants judged the affective meaning of a series of affirmation and negation statements. The behavioral results showed that participants were slower to respond to sentences that end with low pleasure words than those that end with high pleasure words. Furthermore, reaction time differences between high and low pleasure words were reduced when presented in negation context. Analysis of the ERPs locked to final-word presentation revealed that an early effect, N50 (15–85 ms), is sensitive to the valence of the final-word. A later N400 (290–470 ms) effect at centromedial sites differ for high and low pleasure words when they were presented within a negation context. The N400 differences for high and low pleasure words were also present in an affirmative context but occurred over centroparietal sites. Overall, the results suggested that sentence comprehension involves a stage of initial valence information extraction, followed by contextual integration, and that different brain regions are involved at each comprehension stage. [Copyright &y& Elsevier]

Abstract: Three tetrairon ethanedithiolate complexes [{(μ-EDT)Fe2(CO)5}2L] (EDT=SCH2CH2S; L=(η 5-Ph2PC5H4)2Fe, 1; Ph2PCH2CH2PPh2, 2; trans-Ph2PCH=CHPPh2, 3) containing bridging bidentate phosphine ligands were prepared by carbonyl substitution reactions in the presence of the decarbonylating agent Me3NO·2H2O. The new complexes 1–3 were characterized by elemental analysis, IR and 1H (31P, 13C) NMR spectroscopies. Furthermore, their structures were determined by single crystal X-ray diffraction analysis. The molecular structure of 1 is centrosymmetric and the two cyclopentadienyl (Cp) rings reside in a staggered conformation. The molecular structures of 2 and 3 are composed of a zigzag chain, Fe2P1C20C20AP1AFe2A, with the midpoint of the C20–C20A bond as the center of symmetry. [Copyright &y& Elsevier]

Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease characterized by an imbalance between immunological reactivity and immune tolerance. Regulatory T cells (Tregs), which play a crucial role in controlling ongoing autoimmunity and maintaining peripheral tolerance, have shown great potential for the treatment of autoimmune inflammatory rheumatic diseases such as RA. This review aims to provide an updated summary of the latest insights into Treg-targeting techniques in RA. We focus on current therapeutic strategies for targeting Tregs based on discussing their subsets, surface markers, suppressive function, and signaling pathways in RA. • Tregs can be split into tTregs, pTregs and iTregs, which suppress autoimmunity. • FoxP3 is considered to be the most specific marker of Tregs at present. • Tregs exert functions by cell-cell contact, cytokine meditation, markers, and TFs. • Upstream signaling pathways of Tregs trigger rheumatoid arthritis. • Treg targeted, based, and related therapies show potent in rheumatoid arthritis. [ABSTRACT FROM AUTHOR]

Graphical abstract Five diiron ethanedithiolate complexes [Fe 2 (CO) 5 (L){μ-SCH 2 CH(CH 2 O 2 CCH 3)S}] (L = P(2-C 4 H 3 O) 3 , 2 ; P(2-C 4 H 3 S) 3 , 3 ; P(4-C 6 H 4 F) 3 , 4 ; P(4-C 6 H 4 Cl) 3 , 5 ; Ph 2 PC 6 H 11 , 6) containing acetate ester and phosphine ligands were prepared by CO substitution. The complexes 2 – 6 have been characterized by elemental analysis, IR and NMR spectra, as well as by X-ray crystallography. Moreover, the electrochemical properties were also studied. Abstract A series of acetate ester containing diiron ethanedithiolate complexes have been synthesized and structurally characterized. CO substitution of complex [Fe 2 (CO) 6 {μ-SCH 2 CH(CH 2 O 2 CCH 3)S}] (1) with the phosphine ligands tris(2-furyl)phosphine, tris(2-thienyl)phosphine, tris(4-fluorophenyl)phosphine, tris(4-chlorophenyl)phosphine, or cyclohexyldiphenylphosphine in the presence of the decarbonylating agent Me 3 NO·2H 2 O gave the phosphine-substituted diiron derivatives [Fe 2 (CO) 5 (L){μ-SCH 2 CH(CH 2 O 2 CCH 3)S}] (L = P(2-C 4 H 3 O) 3 , 2 ; P(2-C 4 H 3 S) 3 , 3 ; P(4-C 6 H 4 F) 3 , 4 ; P(4-C 6 H 4 Cl) 3 , 5 ; Ph 2 PC 6 H 11 , 6) in 86–95% yields. The complexes 2 – 6 have been characterized by elemental analysis, spectroscopy, and X-ray diffraction analysis. Additionally, the electrochemical properties were investigated by cyclic voltammetry. [ABSTRACT FROM AUTHOR]

Three diiron ethanedithiolate complexes containing pendant ferrocene were prepared and structurally characterized. Reaction of the complex [{ μ -SCH 2 CH(CH 2 OH)S}Fe 2 (CO) 6 ] ( 1 ) with ferrocenecarboxylic acid in the presence of N , N ′-dicyclohexylcarbodiimide and 4-dimethylaminopyridine afforded complex [{ μ -SCH 2 CH(CH 2 O 2 CFc)S}Fe 2 (CO) 6 ] (Fc = ferrocenyl) ( 2 ) in 73% yield. Further treatment of complex 2 with a monophosphine ligand tris(2-methoxyphenyl)phosphine or tris(2-furyl)phosphine in the presence of the decarbonylating agent Me 3 NO·2H 2 O yielded the monophosphine-substituted complexes [{ μ -SCH 2 CH(CH 2 O 2 CFc)S}Fe 2 (CO) 5 P(2-C 6 H 4 OCH 3 ) 3 ] ( 3 ) and [{ μ -SCH 2 CH(CH 2 O 2 CFc)S}Fe 2 (CO) 5 P(2-C 4 H 3 O) 3 ] ( 4 ) in 94% and 85% yields, respectively. The complexes 2 – 4 were characterized by elemental analysis, spectroscopy and X-ray crystallography. In addition, electrochemical properties of the complexes 2 – 4 were studied by cyclic voltammetry. [ABSTRACT FROM AUTHOR]

The development of proton exchange membranes (PEMs) with high loading and stable electrolytes is currently critical and challenging for applications in new energy related devices such as proton exchange membrane fuel cells (PEMFC). In this study, a novel porous organic skeleton (Covalent triazine framework, recorded as CTFp) is synthesized as a material for immobilized guest molecules via a simple nucleophilic substitution reaction. The phosphoric acid molecule (H 3 PO 4) is extruded into the CTFp porous organic framework by vacuum assisted method (VAM). Since the molecular size of H 3 PO 4 is smaller than the window size of the micropores in CTFp, a high loading of H 3 PO 4 is achieved. The large amounts of basic groups distributed in CTFp can form a strong electrostatic interaction with H 3 PO 4 , which ensures the low dynamic leakage of H 3 PO 4. PEMs with high proton conductivity are developed by embedding phosphoric acid-loaded CTFp (H 3 PO 4 @CTFp) in a SPEEK matrix. The acid-base pair formed between H 3 PO 4 @CTFp network and SPEEK optimizes the interfacial interaction and enhances the dispersion of H 3 PO 4 @CTFp in the composite membrane. H 3 PO 4 stored in CTFp provides rich proton hopping sites for proton transport. The hydrogen bond network formed by self-dissociation of high concentration H 3 PO 4 molecules constructs a proton transfer channel with low energy barrier for proton transfer, thereby significantly enhancing the proton conductivity of the membrane. The results show that the proton conductivity of the composite membrane at 80 °C is 0.313 S/cm when the filler content is 15%. It is worth noting that the phosphoric acid leakage rate of H 3 PO 4 @CTFp is only 15.3% after the filler is immersed in water at 60 °C for 30 days. Therefore, the SPEEK/H 3 PO 4 @CTFp composite membranes are promising to develop new PEMs with low acid loss and high proton conductivity. Image 1 • The H 3 PO 4 @CTFp framework network with high phosphoric acid loading and low acid leakage rate was prepared. • The introduction of H 3 PO 4 @CTFp network can effectively alleviate the decay of proton conductivity at 20% RH. • The membrane proton conductivity reaches 0.313 S/cm at 100% RH and 80 °C. • The H 3 PO 4 @CTFp framework endows the composite membrane excellent cell performance. • The composite membrane is expected to replace the PA-doped PEMs used in hydrogen fuel cells. [ABSTRACT FROM AUTHOR]