15 results on '"Jankowska, I."'
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2. Comparison of structural, thermal and proton conductivity properties of micro- and nanocelluloses.
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Jankowska, I., Pankiewicz, R., Pogorzelec-Glaser, K., Ławniczak, P., Łapiński, A., and Tritt-Goc, J.
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PROTON conductivity , *NANOPARTICLES , *FOURIER transform infrared spectroscopy , *NANOCRYSTALS , *X-ray diffraction - Abstract
Graphical abstract Highlights • The properties of selected nano- and microcelluloses were studied and compared. • The thermal properties of cellulose films are similar from 23 °C to about 200 °C. • TEMPO-oxidized CNF film showed the highest proton conductivity. Abstract Our search for a cellulose-based proton conducting material is continued. This paper presents selected physicochemical properties of cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) together with cellulose microcrystals (CMCs) and cellulose microfibrils (CMFs), determined by X-ray diffraction (XRD), thermogravimetric analysis (TGA + DTA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and electrical impedance spectroscopy (EIS). The CNCs and CNFs were studied in the forms of powder and film. They were produced in the process of transition metal catalyzed oxidative process or by TEMPO-mediated oxidation. It has been shown that regardless of the production method and the form of the sample the celluloses retained the cellulose Iβ crystalline structure, the cellulose films showed similar thermal properties in the relevant temperature range from room temperature to about 200 °C, and the TEMPO-oxidized CNF film showed the highest proton conductivity when compared with those of the other samples studied. [ABSTRACT FROM AUTHOR] more...
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- 2018
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3. Progressive familial intrahepatic cholesstasis: mutation analysis and evidence for a third locus
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Strautnieks, S.S., Byrne, J., Soler, E., Knisely, A., Bull, L., Jankowska, I., Pawlowska, J., Freimer, N., Sokal, E., Mieli-Vergani, G., and Thompson, R.
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- 2001
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4. Prevention of de Novo Hepatitis B Virus Infection by Vaccination and High Hepatitis B Surface Antibodies Level in Children Receiving Hepatitis B Virus Core Antibody-Positive Living Related Donor Liver: Case Reports
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Jankowska, I., Pawłowska, J., Teisseyre, M., Kaliciński, P., Kamiński, A., Czubkowski, P., Cielecka-Kuszyk, J., Kluge, P., Pronicki, M., and Socha, J.
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HEPATITIS B virus , *ORGAN donors , *LIVER transplantation , *PATIENTS - Abstract
Abstract: Transmission of hepatitis B virus (HBV) infection from donors negative for hepatitis B surface antigen (HBsAg) but positive for antibody to hepatitis B core antigen (anti-HBc) have been reported. The aim of our study was to evaluate the outcomes of recipients who received liver grafts from living related donors with serological evidence of previous exposure to hepatitis B virus (HBsAg-negative/anti-HBc-positive) after recipient vaccination against HBV before and after liver transplantation. [Copyright &y& Elsevier] more...
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- 2007
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5. Combined Liver-Kidney Transplantation in Children: Single-Center Experiences and Long-Term Results.
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Szymczak, M., Kaliciński, P., Kowalewski, G., Markiewicz-Kijewska, M., Broniszczak, D., Ismail, H., Stefanowicz, M., Kowalski, A., Teisseyre, J., Rubik, J., Grenda, R., Jankowska, I., and Piątosa, B.
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TRANSPLANTATION of organs, tissues, etc. in children , *KIDNEY transplantation , *LIVER transplantation , *SURVIVAL analysis (Biometry) , *COMPLICATIONS from organ transplantation - Abstract
Abstract Combined liver-kidney transplantation (CLKT) is a rare procedure in pediatric patients in which liver and kidney from 1 donor are transplanted to a recipient during a single operation. The aim of our study was to analyze indications and results of CLKT in children. Materials and Methods Between 1990 and 2017 we performed 722 liver transplantations in children; we performed 920 kidney transplantations in children since 1984. Among them, 25 received CLKT. Primary diagnosis was fibro-polycystic liver and kidney disease in 17 patients, primary hyperoxaluria type 1 in 6 patients, and atypical hemolytic uremic syndrome-related renal failure in 2 children. Age of patients at CLKT was 3 to 23 years (median 16 years) and body mass was 11 to 55 kg (median 35.5kg). All patients received whole liver graft. Kidney graft was transplanted after liver reperfusion before biliary anastomosis. Cold ischemia time was 5.5 to 13.3 hours (median 9.4 hours) for liver transplants and 7.3 to 15 hours (median 10.4 hours) for kidney transplants. In 8 patients X-match was positive. We analyzed posttransplant (Tx) course and late results in our group of pediatric recipients of combined grafts. Results Tx follow-up ranged from 1.5 to 17 years (median 4.5 years). Two patients died: 1 patient with oxalosis lost renal graft and died 2.6 years after Tx due to complications of long-term dialysis, and 1 died due to massive bleeding in early postoperative period. Twelve patients were transferred under the care of adult transplantation centers. Six patients were dialyzed after CLKT due to acute tubular necrosis, and time of kidney function recovery was 10 to 27 days in these patients. In 1 patient with aHUS, renal function did not recover. In children with oxalosis, hemodialysis was performed for 1 month after Tx as a standard, with the aim to remove accumulated oxalate. Primary immunosuppression consisted of daclizumab or basiliximab, tacrolimus, mycophenolate mofetil, and steroids. Acute rejection occurred in 4 liver and 3 kidney grafts. One patient required liver retransplantation due to hepatitis C virus recurrence and 2 patients required kidney retransplantation. Two patients required dialysis. Conclusions CLKT in children results in low rate of rejection and high rate of patient and graft survival. Highlights • Combined liver-kidney transplantation in children is followed by a low rate of rejection. • Good results in patients and graft survival. • Transplantations are feasible even in recipients with low body weight below 10 kg. [ABSTRACT FROM AUTHOR] more...
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- 2018
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6. Liver Transplantation in Polish Children With α1-Antitrypsin Deficiency: A Single-Center Experience.
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Bakula, A., Pawlowska, J., Niewiadomska, O., Jankowska, I., Teisseyre, M., Kaliciński, P., and Socha, P.
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LIVER transplantation , *CHILDREN , *ALPHA 1-antitrypsin deficiency , *HEPATITIS in children , *BLOOD coagulation disorders - Abstract
Background α 1 -Antitrypsin deficiency (ATD) is the most common genetic cause of liver injury in young children. Asymptomatic hepatitis is observed in most patients. However, the course of liver disease due to ATD is unpredictable, and some children develop liver cirrhosis. Liver transplantation (Ltx) dramatically improves their outcome and in some cases is required in the first years of life. The aim of the study was to evaluate the course of the disease in children with ATD treated with Ltx in a single center. Methods We retrospectively reviewed the clinical features (ascites, esophageal varices, esophageal bleeding) and laboratory parameters of liver function in children with ATD who were treated with Ltx. Results Twenty-two Ltxs were performed in 20 children (13 boys, 7 girls). Median age at transplantation was 12 years (range 0.5 to 17.1). Four children were transplanted in the first 2 years of life and 16 patients were over 7 years old. The indications for Ltx in younger children were progressive cholestasis with coagulopathy and ascites. In older patients, the indications were as follows: liver failure presenting with variceal bleeding in 7 patients, ascites in 5 patients, hypersplenism in all but 1 patient. In the group of children transplanted over 7 years old, the frequency of cholestasis decreased intermittently in the second year of life: 4 patients (25%) compared to 15 patients (94%) and 10 patients (63%) in the neonatal and pretransplant period, respectively. In the group of children transplanted earlier, cholestasis and hepatitis were maintained until Ltx. Of transplanted patients, 50% were malnourished at the transplantation, and 50% were followed for more than 10 years. Five-year post-transplant survival was 100% (n = 14), and 10-year survival was 90%. Two patients died as adults with biliary post-transplant complications and problems with compliance. Conclusions Our experience suggests that transient normalization of liver parameters in some patients with ATD do not exclude the liver disease progression to cirrhosis and unfavorable outcome of liver disease in childhood. In our group of patients, median age at transplantation was high compared to other centers. The long-term prognosis in children after transplantation is very good, but early post-transplant complications and probable problems with compliance in young adults may lead to graft failure. [ABSTRACT FROM AUTHOR] more...
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- 2016
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7. Toxic liver injury of transplanted liver: a case report of a 15-year-old boy
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Pawlowska, J., Teisseyre, M., Jankowska, I., Kamiński, A., Kaliciński, P., Markiewicz, M., Cielecka-Kuszyk, J., and Kluge, P.
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- 2002
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8. Liver Transplantation for Severe Hepatic Graft-Versus-Host Disease in Two Children After Hematopoietic Stem Cell Transplantation
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Teisseyre, M., Teisseyre, J., Kalicinski, P., Wolska-Kusnierz, B., Ismail, H., Bernatowska, E., Markiewicz-Kijewska, M., Ostoja-Chyzynska, A., Jankowska, I., Kluge, P., Pawlowska, J., and Szymczak, M. more...
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GRAFT versus host disease , *LIVER transplantation , *STEM cell transplantation , *HEMATOPOIETIC stem cells , *BONE marrow transplant complications , *HYPERBILIRUBINEMIA , *BILE duct diseases , *ORGAN donors - Abstract
Abstract: Chronic graft-versus-host disease (GVHD) is a frequent complication of bone marrow transplantation (BMT). After the skin, the liver is the second, most frequent target of GVHD, which presenting with hyperbilirubinemia, elevated liver enzymes, and coagulopathy. Progressive destruction of small intrahepatic bile ducts causes vanishing bile duct syndrome and leads to end-stage liver disease. We report 2 successful cases of orthotopic liver transplantation performed in children with severe GVHD after hematopoietic stem cell transplantation from a matched unrelated donor (HSCT-MUD). [Copyright &y& Elsevier] more...
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- 2010
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9. Effect of Lactobacillus casei DN-114001 Application on the Activity of Fecal Enzymes in Children After Liver Transplantation
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Pawłowska, J., Klewicka, E., Czubkowski, P., Motyl, I., Jankowska, I., Libudzisz, Z., Teisseyre, M., Gliwicz, D., and Cukrowska, B.
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LACTOBACILLUS , *LIVER transplantation , *ENZYMES , *PROTEINS - Abstract
Abstract: Immunosuppressive and antibacterial regimens in children after liver transplantation create a gut microflora imbalance that can be indirectly measured by the activity of fecal enzymes. The aim of this study was to specify the influence of diet supplementation with probiotic Lactobacillus casei DN on the activity of β-glucuronidase, β-glucosidase, and urease. Twenty-five children after liver transplantation (13 girls, 12 boys) ages 3 to 17 years were enrolled in the study. Two months after bacteria application the levels of all 3 enzymes decreased, reaching statistical significance for β-glucuronidase and β-glucosidase. Complete rebound in enzyme activity was observed months after the end of probiotic supplementation. We concluded that Lactobacillus casei DN-114001 consumption decreased fecal enzyme activity, a beneficial effect limited to the period of bacteria intake. [Copyright &y& Elsevier] more...
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- 2007
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10. Good and Bad Prognosis of Alpha-1-Antitrypsin Deficiency in Children: When to List for Liver Transplantation
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Bakula, A., Socha, P., Pawlowska, J., Teisseyre, M., Jankowska, I., and Kalicinski, P.
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LIVER transplantation , *LIVER diseases , *HEPATITIS , *MEDICAL genetics - Abstract
Abstract: α1-antitrypsin deficiency (α1-ATD) is a genetic disorder that may predispose to chronic liver disease. The clinical manifestations and prognosis of this disorder are variable. The aim of the study was to evaluate the clinical presentation and liver tests in two groups of children with α1-ATD: those with a good prognosis who survived long term with their native liver, and those with a bad one, requiring liver transplantation (OLT) or dying before OLT. We studied 59 children homozygous for α1-ATD admitted to our hospital with cholestasis or chronic hepatitis since infancy. Patients without liver transplantation were regarded to be the good prognosis group I (n = 45). In contrast the 11 children who required liver transplantation and the three who died before OLT were the bad prognosis cohort (Group II, n = 14). We analyzed the laboratory parameters of cholestasis, hepatitis, and liver insuficiency in both groups. In the group with a good prognosis, eight children still suffered from cholestasis at the ages of 9 to 14 years while nine had hepatitis at the ages of 9 to 14 years. We observed a temporarily increased international normalized ratio (1.2 to 1.5) in eight subjects at the ages of 1 month to 17 years, and slight hypoalbuminemia (30 to 35 mg/dL) in nine children at the ages of 1 month to 10 years. OLT was performed in 11 children at the ages of 10 to 17 years. Our center’s experience suggested that in the PiZZ patients with portal hypertension, esophageal varices, or deterioration of hepatic function, liver transplantation should not be delayed. [Copyright &y& Elsevier] more...
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- 2007
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11. Lipid, Carbohydrate Metabolism, and Antioxidant Status in Children After Liver Transplantation
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Wierzbicka, A., Pawłowska, J., Socha, P., Jankowska, I., Skorupa, E., Teisseyre, M., Ismail, H., Czubkowski, P., and Socha, J.
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METABOLISM , *TRANSPLANTATION of organs, tissues, etc. , *LIPIDS , *CARBOHYDRATES - Abstract
Abstract: Organ transplantation is a risk factor for atherogenesis that may be related to immunosuppressive therapy. Increased free radical generation may even aggrevate atherogenesis. The aim of the study was to assess lipid metabolism in relation to risk factors for atherogenesis as well as carbohydrate metabolism and antioxidant status among children after liver transplantation. We studied 35 children at 3 to 5 years after liver transplant in whom the following parameters were asssesed: total cholesterol; triglyceride; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol (LDL-C); very low-density lipoprotein cholesterol; apolipoproteins B, AI, E, lipoprotein (a); vitamin E; glutathione; glucose; insulin; and glutathione peroxidase activity. Three subgoups of patients were assessed according to the immunosuppresive therapy: cyclosporine (CsA), tacrolimus (Tac), or mycophenolate mophetil (MMF) in combination with low-dose CsA or Tac. We observed differences among the subgroups only in total cholesterol (CsA: 131.6 to 285.6; Tac: 144.0 to 181.61; MMF: 132.1 to 181.2) and LDL-C (CsA: 79.4 to 126.9; Tac: 42.2 to 118.8; MMF: 74.2 to 117.3). Lipid metabolism was not significantly disturbed among children after liver transplantation, an observation that does not point to a high risk of atherogenesis. CsA seems to have the strongest untoward effect on cholesterol metabolism. Decreased GSH concentration after liver transplantation may be related to slightly impaired liver function, but GPx activity and vitamin E concentrations remained normal. [Copyright &y& Elsevier] more...
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- 2007
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12. Outcome of Four High-Risk Pregnancies in Female Liver Transplant Recipients on Tacrolimus Immunosuppression
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Jabiry-Zieniewicz, Z., Kamiński, P., Pietrzak, B., Cyganek, A., Bobrowska, K., Ziółkowski, J., Ołdakowska-Jedynak, U., Zieniewicz, K., Pączek, L., Jankowska, I., Wielgoś, M., and Krawczyk, M.
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LIVER transplantation , *PREGNANCY complications , *IMMUNOSUPPRESSION , *WOMEN'S health , *IMMUNOREGULATION , *TACROLIMUS - Abstract
Abstract: Pregnancies in women after liver transplantation are considered high risk due to the greater rate of complications observed in immunosuppressed graft recipients. We report successful outcomes of four high-risk pregnancies in female liver transplant recipients on tacrolimus-based immunosuppression. The patients, aged 23 to 32 years, at the time of conception were 12 to 59 months from transplantation (mean 30 months). Preterm labor was the most important pregnancy complication observed in these patients. One episode of acute graft rejection was observed. A variable demand for tacrolimus was noted during pregnancy. Despite complications all four pregnancies were successful. The mean gestational age at delivery was 34.4 weeks. The birth weight of the newborns varied from 1410 to 3490 g (mean 2303 g) and the mean Apgar score was 8. No structural malformations or early complications were observed in the newborns. Excluding the patient with acute rejection, the remaining three cases showed all liver parameters to remain stable. [Copyright &y& Elsevier] more...
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- 2006
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13. Reduction of naive CD4/CD45RA+ T cells in children with biliary atresia before and after liver transplantation
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Pawlowska, J., Michalkiewicz, J., Czubkowski, P., Jankowska, I., Teisseyre, M., Socha, P., Kalicinski, P., and Socha, J.
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LIVER transplantation , *LYMPHOCYTES , *BILIARY atresia , *T cells - Abstract
The aim of this study was to examine whether liver transplantation reverses the abnormal distribution of lymphocyte subsets previously observed in biliary atresia children, namely a selective decrease in the naive CD4/CD45RA+ T cell subset and an increase in the B and natural killer cell subpopulations. Eight biliary atresia children aged 1.08 to 6 years were studied before and 1 year after LTx for comparison with 15 age-matched healthy controls. The posttransplant immunosuppressive regimens included prednisone [0.1 mg/kg] and tacrolimus (level range: a 10–12 μg/dL). The percentage, absolute cell number, and receptor density were assessed by the use of double color flow cytometry (EPICS-XL MCL fluorocytometer). Biliary atresia patients were compared after LTx with subjects before LTx, essentially showing no statistically significant changes in lymphocyte subsets. We conclude that LTx of biliary atresia children does not reverse the abnormal lymphocyte subset distribution present before transplantation. Hence, these changes may reflect either their independence from the liver status or may result from immunosuppressive treatment that contributes to defective CD4+ T cell regeneration reflected by a deficiency in CD4/CD45RA+ naive T cells. [Copyright &y& Elsevier] more...
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- 2003
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14. Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis
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Pawlowska, J., Matusik, H., Socha, P., Ismail, H., Ryżko, J., Karczmarewicz, E., Jankowska, I., Teisseyre, M., and Lorenc, R.
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INFANT diseases , *CHOLESTASIS , *LIVER transplantation , *BLOOD plasma - Abstract
Reports of bone mineral density in children after liver transplantation are few. Eleven cholestatic children were analyzed before and 6 months after liver transplantation. No changes in serum levels of calcium, alkaline phosphates, or 25OHD were observed before versus after LTx. The serum levels of phosphorus and 1-25(OH)2D3 as well as total bone mass density and Cole index were significantly increased after liver transplantation. [Copyright &y& Elsevier] more...
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- 2004
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15. Liver transplantation in three family members after Amanita phalloides mushroom poisoning
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Pawlowska, J., Pawlak, J., Kaminski, A., Jankowska, I., Hevelke, P., Teisseyre, M., Szymczak, M., Kalicinski, P., and Krawczyk, M.
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- 2002
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