1. Bleomycin enhances the efficacy of sonodynamic therapy using aluminum phthalocyanine disulfonate.
- Author
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Tomohiro Osaki, Inoru Yokoe, Yoshihiro Uto, Masahiro Ishizuka, Toru Tanaka, Nobuyasu Yamanaka, Tsukasa Kurahashi, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, and Yoshiharu Okamoto
- Subjects
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ALUMINUM phthalocyanine , *BLEOMYCIN , *SULFONATES , *COLON cancer treatment , *PHOTODYNAMIC therapy - Abstract
Sonodynamic therapy (SDT), or ultrasound combined with sonosensitization, is a promising approach because it is noninvasive and penetrates deeper than light does in photodynamic therapy. We examined whether bleomycin (BLM) could improve the efficacy of SDT. We performed an in vitro study using Colon-26 cells, which are derived from mouse colon cancer. SDT with BLM was significantly more cytotoxic than SDT alone both in vitro and in vivo. We also observed an ultrasound intensity-dependent cytotoxic effect of SDT with BLM. These findings suggest that SDT with BLM might provide a novel noninvasive treatment for deep-seated tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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