1. Lean tissue mass measurements by dual-energy X-ray absorptiometry and associations with strength and functional outcome measures in facioscapulohumeral muscular dystrophy.
- Author
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Wang, Leo H., Leung, Doris G., Wagner, Kathryn R., Lowry, Sarah J., McDermott, Michael P., Eichinger, Katy, Higgs, Kiley, Walker, Michaela, Lewis, Leann, Martens, William B., Mul, Karlien, Sansone, Valeria A., Shieh, Perry, Elsheikh, Bakri, LoRusso, Samantha, Butterfield, Russell J., Johnson, Nicholas, Preston, Matthew R., Messina, Carmelo, and Carraro, Elena
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FACIOSCAPULOHUMERAL muscular dystrophy , *LEAN body mass , *DUAL-energy X-ray absorptiometry , *MASS measurement , *NEUROMUSCULAR diseases - Abstract
• There is moderate correlation between upper extremity lean tissue mass as measured by DEXA scans and their corresponding strengths measured by quantitative muscle testing. • There is moderate correlation between lower extremity lean tissue mass and corresponding strength measured by quantitative muscle testing and manual muscle testing. • There is moderate correlation between bilateral lower extremity lean tissue mass and 6-minute walk test, 10-meter walk/run, and timed-up-and-go. Facioscapulohumeral muscular dystrophy (FSHD) is a slowly progressive disease of skeletal muscle. Dual energy X-ray absorptiometry (DEXA) is a widely available, cost-effective and sensitive technique for measuring whole body and regional lean tissue mass and has been used in prior clinical trials in neuromuscular diseases. The Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD (ReSolve) study is a prospective, longitudinal, observational multisite study. We obtained concurrent DEXA scans and functional outcome measurements in 185 patients with FSHD at the baseline visit. We determined the associations between lean tissue mass in the upper and lower extremities and corresponding clinical outcome measures. There were moderate correlations between upper and lower extremity lean tissue mass and their corresponding strengths and function. Lean tissue mass obtained by DEXA scan may be useful as a biomarker in future clinical trials in FSHD. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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