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Objectives Social isolation and loneliness have been associated with ill health and are common in the developed world. A clear understanding of their implications for morbidity and mortality is needed to gauge the extent of the associated public health challenge and the potential benefit of intervention. Study design A systematic review of systematic reviews (systematic overview) was undertaken to determine the wider consequences of social isolation and loneliness, identify any differences between the two, determine differences from findings of non-systematic reviews and to clarify the direction of causality. Methods Eight databases were searched from 1950 to 2016 for English language reviews covering social isolation and loneliness but not solely social support. Suitability for inclusion was determined by two or more reviewers, the methodological quality of included systematic reviews assessed using the a measurement tool to assess systematic reviews (AMSTAR) checklist and the quality of evidence within these reviews using the grading of recommendations, assessment, development and evaluations (GRADE) approach. Non-systematic reviews were sought for a comparison of findings but not included in the primary narrative synthesis. Results Forty systematic reviews of mainly observational studies were identified, largely from the developed world. Meta-analyses have identified a significant association between social isolation and loneliness with increased all-cause mortality and social isolation with cardiovascular disease. Narrative systematic reviews suggest associations with poorer mental health outcomes, with less strong evidence for behavioural and other physical health outcomes. No reviews were identified for wider socio-economic or developmental outcomes. Conclusions This systematic overview highlights that there is consistent evidence linking social isolation and loneliness to worse cardiovascular and mental health outcomes. The role of social isolation and loneliness in other conditions and their socio-economic consequences is less clear. More research is needed on associations with cancer, health behaviours, and the impact across the life course and wider socio-economic consequences. Policy makers and health and local government commissioners should consider social isolation and loneliness as important upstream factors impacting on morbidity and mortality due to their effects on cardiovascular and mental health. Prevention strategies should therefore be developed across the public and voluntary sectors, using an asset-based approach. [ABSTRACT FROM AUTHOR]

Objectives: Responsibility for the commissioning of sexual and reproductive health (SRH) services transferred from the National Health Service to local authorities in England in 2013. This transfer prompted many local authorities to undertake new procurements of these SRH services. This study was undertaken to capture some of the lessons learnt in order to inform future commissioning and system redesign. Study design: A qualitative study was carried out involving semi-structured interviews. Methods: Interviews were conducted with 13 local authority sexual health commissioners in Yorkshire and the Humber from 11 interviews. Thematic analysis was used to identify themes from transcripts of the interviews with the 13 participants. Results: Key themes identified were as follows: the challenge and complexity to those new to clinical commissioning; the prerequisites of robust infrastructural inputs to undertake the process, including technical expertise, a dependable project team, with clarity over the timescales and the budget; the requirement for good governance, stakeholder engagement and successful management of relationships with the latter; and the need to focus on the outcomes, aiming for value for money and improved system performance. Conclusions: Several key issues emerged from our study that significantly influenced the outcome of the redesign and commissioning process for sexual health services. An adapted model of the Donabedian evaluation framework was developed to provide a tool to inform future system redesign. Our model helps identify the key determinants for successful redesign in this context which is essential to both mitigate potential risks and maximize the likelihood of successful outcomes. Our model may have wider applications. [ABSTRACT FROM AUTHOR]

Abstract: Introduction: Ballistic gelatin is well validated in its ability to simulate the retardation of bullets into homogenous muscle. However the relationship is less clear for fragmentation projectiles and non-homogenous tissues as would truly be found in a human. Method: 0.16 g, 1.10 g and 2.84 g NATO standardised cylindrical Fragment Simulating Projectiles (FSPs) were fired at a range of velocities (112–1652 m s−1) into four body areas (thigh, abdomen, thorax or neck) of six pig cadavers as well as 20% gelatin. Cadavers were imaged by Computed Tomography (CT) scanning and FSP Depth of Penetration (DoP) ascertained through radiology followed by dissection by a forensic pathologist. Results: 106/149 (71%) FSPs were retained in tissues enabling DoP measurements and 43/149 (29%) exited the subjects. There was significantly less retardation of FSPs in the thorax and abdomen compared to gelatin but no difference in retardation in leg and neck tissue compared to gelatin. Although the gradient appeared identical for the 2.84 g FSP as well, there were insufficient FSPs retained in the neck and leg for meaningful analysis to be undertaken. Discussion: Porcine leg and neck muscle was demonstrated to be comparable to 20% ballistic gelatin in terms of retardation, validating the use of projectile penetration algorithms derived from this tissue simulant. The effect of pig skin was significant for the 0.16 g FSP, especially at lower velocities, and we would therefore suggest that specific algorithms for any future numerical injury models be based directly from animal data or validated skin simulants for this smaller sized FSP. Reproducing the retardation effects of FSPs in the thorax and abdomen using tissue simulants alone will be problematic due to the anatomical complexity as well as multiple tissue–air interfaces and we would recommend further research in this area. [Copyright &y& Elsevier]

Abstract: Temporal and spatial patterns of relative sea level (RSL) change in the North of Britain and Ireland during the Holocene are examined. Four episodes, each defined by marked changes in the RSL trend, are identified. Each episode is marked by a rise to a culminating shoreline followed by a fall. Episode HRSL-1 dates from the Younger Dryas to early in the Holocene; HRSL-2 to HRSL-4 occurred later in the Holocene. There is extensive evidence for each episode, and on this basis the spatial distribution of the altitude data for three culminating shorelines and a shoreline formed at the time of the Holocene Storegga Slide tsunami (ca 8110 ± 100 cal. BP) is analysed. Ordinary Kriging is used to determine the general pattern, following which Gaussian Trend Surface Analysis is employed. Recognising that empirical measurements of RSL change can be unevenly distributed spatially, a new approach is introduced which enables the developing pattern to be identified. The patterns for the most widely occurring shorelines were analysed and found to be similar and common centre and axis models were developed for all shorelines. The analyses described provide models of the spatial pattern of Holocene RSL change in the area between ca 8100 cal. BP and ca 1000 cal. BP based on 2262 high resolution shoreline altitude measurements. These models fit the data closely, no shoreline altitude measurement lying more than −1.70 m or +1.82 m from the predicted value. The models disclose a similar pattern to a recently published Glacial Isostatic Adjustment model for present RSL change across the area, indicating that the overall spatial pattern of RSL change may not have varied greatly during the last ca 8000 years. [Copyright &y& Elsevier]

This paper discusses the introduction, development and utility of post-mortem imaging relating specifically to conflict-related and terrorist-related deaths and considers the use of computed tomography (CT) in the investigations. We demonstrate how a multi-disciplinary approach involving direct communication between forensic pathologist and radiologist can maximise evidential yield, reduce the need for unnecessary dissection and further our understanding of such injuries. This summarises our shared experience of hundreds of cases, each having been individually discussed and reviewed, and has helped shape our understanding of conflict injury as well as contributing to the development of mitigation strategies and adaptations to protective equipment. A series of clinical cases are presented to demonstrate some of the strengths and weaknesses of the process. • Development of post-mortem CT in forensic radiology by UK military. • Collaborative learning and working between radiology, pathology and police. • What the forensic pathologist and police want from CT. • What radiology can answer from a pragmatic PMCT study. • Strengths and weaknesses of the technique through case scenarios. [ABSTRACT FROM AUTHOR]

Abstract: Penetrating explosive fragments are the most common cause of neck injuries sustained by UK service personnel deployed to Afghanistan. Analysis of these fragments will enable future ballistic protective materials to be tested with appropriate projectiles. However, only a small number of fragments excised from the neck have been available for analysis and they are potentially unrepresentative. We analysed computed tomograms (CTs) of 110 consecutive UK soldiers whose necks were wounded by explosive fragments. Fragments were classified according to shape, and their dimensions used to estimate volume and mass. These calculations were then compared with the actual measurements of the excised fragments using a general linear model. The 2 most common shapes were cylinders (52%) and spheres (21%). Known and estimated masses were not significantly different (p =0.64). A fragment-simulating projectile of 0.49g represented 85% of fragments retained in the neck. CT can accurately delineate the shape and mass of fragments, which increases the number from which the most appropriate simulated projectile can be designed. We think that this methodology should be applied to fragments retained in other parts of the body to enable broader recommendations to be made regarding the testing of ballistic materials used to protect service personnel. [Copyright &y& Elsevier]

Clozapine is a uniquely effective antipsychotic, but is very toxic in clozapine-naïve subjects. A 34-year-old male patient in a mental health facility, who was not prescribed clozapine, took 350 mg clozapine obtained from another patient at night. He was found dead the next morning. The presence of cardiomegaly related to obesity may have increased the risk of suffering an acute cardiac event after ingestion of clozapine. The medication prescribed to the patient was not thought to have contributed to the fatal outcome. Post mortem femoral blood clozapine and norclozapine concentrations were 0.48 and 0.20mg/L, respectively. By way of comparison, audit of 104,127 plasma samples (26,796 patients) assayed for therapeutic drug monitoring purposes 1993-2007, showed plasma clozapine 0.35 mg/L or more in 57.5% samples (8.4% 1mg/L or more). Those involved in the investigation of clozapine-associated deaths need to be aware that that death in an adult may occur after a single 'therapeutic' dose. A diagnosis of fatal clozapine poisoning cannot be made solely on the basis of a post mortem blood clozapine measurement. [ABSTRACT FROM AUTHOR]

Estimating the correct nail length for solid tibial nails can be problematic. Most techniques reported in the literature for determining tibial nail length are not accurate. In a retrospective study of 16 patients in our unit, only three had ideal nail sizes. In these patients, as part of phase I of our study, we measured their normal leg’s length from knee joint line to ankle joint line. An ideal nail length for each of these patients was estimated from a whole length radiograph of the nailed tibia. Comparing these two data, we found that deducting 20 mm from the leg measurement gave appropriate nail lengths. We also compared this with three other anthropometric measurements; tibial tuberosity to medial malleolus, joint line to medial malleolus and olecranon to head of V metacarpal head distance. The joint line to joint line measurement was the most reliable and showed the best correlation with ideal nail lengths (0.982).In phase II, a prospective study on 15 patients, we used the joint line to joint line measurement to determine nail sizes. A postoperative review of the radiographs showed all the nails to be of adequate length. This strengthened the fact that the joint line to joint line measurement is the most accurate and easy method to determine tibial nail lengths. [Copyright &y& Elsevier]

Abstract: Background: Injection drug use is a skill learned in social settings. Change the Cycle (CTC), a peer-delivered, one-session intervention, is designed to reduce among people who inject drugs (PIDs) injection initiation-related behaviours (i.e., speaking positively about injecting to non-injectors, injecting in front of non-injectors, explaining or showing a non-injector how to inject) and initiation of non-injectors. We hypothesized that participation in CTC would lead to reductions in initiation-related behaviours six months later. Methods: Using respondent driven sampling (RDS), 98 PIDs were recruited in Toronto, Canada to participate in pilot testing of CTC. The baseline session consisted of a structured interview, the peer-delivered CTC intervention, instructions regarding RDS coupon distribution, and an invitation to return in six months for a follow-up interview. For the 84 PIDs completing the six-month interview, we compared initiation-related behaviours at baseline with six-month follow-up. Results: The proportion of PIDs offering to initiate a non-injector was reduced from 8.4% (95% CI: 2.5, 15.9) at baseline to 1.59% (95% CI: 0.4, 3.7) at 6-month follow-up. The prevalence of speaking positively about injection to non-injectors also decreased significantly. The proportion of PIDs who helped a non-injector with a first injection at baseline was 6.2% (95% CI: 2.1, 11.3) and at follow-up was 3.5% (95% CI: 0.8, 7.1). Paired analyses of initiator baseline versus follow-up data showed a 72.7% reduction in initiation (95%CI: 47.7, 83.1). Conclusions: While further refinements remain to be tested, pilot study results suggest that CTC holds promise as a prevention intervention. [Copyright &y& Elsevier]

Drawing on data from recent surveys and pilot qualitative interviews among injecting drug users (IDUs) in England, we highlight the potential 'normalisation' of the use of the femoral vein (groin) as a site of injection. We estimate that 45% (428/952) of IDUs in English cities report groin injecting in the last 4 weeks, rising to over 50% in some areas. We also note transitions towards the injection of crack cocaine among poly drug injectors in some UK locations. We estimate that 40% (381/952) of IDUs in English cities report crack injection in the last 4 weeks, rising to over 70% in some cities. Findings from pilot qualitative interviews among homeless injectors in London are suggestive of groin injecting being situated as an 'acceptable risk'. We emphasise the need for research to explore the potential interplay between unstable housing, groin injecting and crack injecting. We call for renewed emphasis within harm reduction interventions advising injectors how to maximise the health and longevity of arm and other peripheral veins, and for greater preparedness to advise known groin injectors how to minimise health risks associated with groin injecting. [ABSTRACT FROM AUTHOR]

Abstract: Subsurface horizontal flow reed beds are being evaluated for Nitrogen (N) and Phosphorus (P) removal from plant nursery runoff water in New South Wales Australia. The need to include plants (Phragmites australis), the effect of reaction time (3.5 v 7.0d) and dissolved organic carbon (DOC) on N and P removal in batch fed gravel wetland tubs (55L) was studied over 19 months. Simulated nursery runoff water containing N (10.1mgL−1, 74% as NO3) and P (0.58mgL−1, 88% as PO4) and DOC (2–5mgL−1) was used. The planted wetland tubs removed >96% TN and TP over most of the 19-month study period while unplanted tubs were inefficient (<16% N and <45% P removal) and occasionally discharged nutrients. Doubling the reaction time to 7.0 days had no effect on nutrient removal. Plant nutrient uptake accounted for most of the N (76%) and P (86%) removed while roots and rhizomes were the dominant sink (N 58%, P 67%). The addition of methanol (C:N–3:1) to unplanted tubs achieved 81–98% N removal. In Carbon limited low nutrient nursery runoff, plants were essential to a gravel-based wetland to achieve efficient nutrient removal with effluent TN and TP concentrations of <1mgL−1 and 0.05mgL−1, respectively with a 3.5 day reaction time. [Copyright &y& Elsevier]