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Background Although participation is a core concept inmultiplemodels of disability, there is no consensus on its definition. Objective The aim of this study was to extract participation domains based on review of theories, available outcome measures, and interviews with experts and the person with hand injuries to compare with the ICF domains of participation. Methods A qualitative approach using a deductive content analysis was employed to extend definitions of participation from theories. Later on, inductive qualitative method using semistructured interview with five experts in different fields and 30 patients with different hand injuries was used. Coding was performed with extracted domains from the content of data, and finally, the extracted domains were compared with the ICF domains of participation. Results Some of the extracted domains were not considered in ICF. Conclusion Subjective participation is the main forbearance part. Role, leisure, domestic life, environment, and others are also main missingmeanings. This limitation can hinder measuring disability and health. [ABSTRACT FROM AUTHOR]

In Alzheimer's disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression. • Neuropsychiatric symptoms are linked to tau pathology from the early disease stages. • Neuropsychiatric symptoms increase as tau pathology becomes more severe. • Tau accumulation may precede the onset of neuropsychiatric symptoms. • PET-based Braak staging predicts future behavioral symptoms in Alzheimer's disease. [ABSTRACT FROM AUTHOR]