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Immunoglobulin G4 (IgG4)-related disorders in various organs have recently been described, but multiple systemic aneurysms have not yet been reported. Here, we present a 68-year-old Japanese man with multiple systemic aneurysms and tumor-forming pericoronary arteritis who was undergoing low-dose corticosteroid therapy. Elevated serum IgG4 (2390 mg/dL) and IgG4-positive plasmacyte infiltration in the salivary glands led to a diagnosis of IgG4-related disease. High-dose corticosteroid therapy was initiated, whereupon the inflammatory lesions shrank. However, the large, well-developed common hepatic aneurysm and splenic aneurysm did not change. Our patient died of splenic aneurysm rupture in the sixth month of treatment. The autopsy revealed IgG4-positive plasmacyte infiltration in the coronary wall and a thinned splenic aneurysm wall. This case suggests that early high-dose corticosteroid therapy may be necessary for the treatment of IgG4-related cardiovascular disorders. A minor salivary gland biopsy might facilitate the early diagnosis of IgG4- related disease even if 18F-fluorodeoxyglucose positron emission tomography provides no inflammatory findings. [ABSTRACT FROM AUTHOR]

MALT (Micro-Analysis Laboratory, Tandem accelerator) at The University of Tokyo is a research and service facility for elemental and isotopic analysis using a tandem accelerator for AMS, PIXE and NRA. Among these, AMS is the most promising technique at MALT. After the AMS-8 conference in 1999, the overall performance was greatly improved for 10Be-, 26Al- and 14C-AMS. For 10Be-AMS, the negative ion current was considerably increased by a new Cs-ionizer system and the replacement of the compound powder (Nb instead of Ag) for the BeO target. More than 3 μA current of BeO− ions can be extracted while it had been typically 1 μA before. For 26Al-AMS, by examining the sample ignition process, the negative ion gain was increased more than 200 nA (typically 100 nA before), which greatly improved the overall efficiency. For 14C-AMS, the 12C− current dependency problem has been moderated substantially by installing a fine controllable Cs oven and careful beam tuning. As a consequence, the precision is now better than 0.5% for modern carbon. In addition, systems for 36Cl-AMS and 129I-AMS are currently being developed for future research programs at MALT. [Copyright &y& Elsevier]