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Abstract: Objective: The long QT syndrome (LQTS) is an inherited cardiac disorder which predisposes the mutation carrier to ventricular arrhythmias that can lead to sudden death. The objective of the present study was to examine the association between the symptom status of congenital long QT syndrome mutation carriers and their temperament. Methods: The study subjects included 587 LQTS mutation carriers from the Finnish LQTS registry, and 2056 individuals from a database study, the Young Finns Study (YFS), representing general population and serving as control subjects. The LQTS subjects were divided into symptomatic (n=259) and asymptomatic (n=328) groups, according to their history of arrhythmic events. Temperament was assessed using the Cloninger''s Temperament and Character Inventory (TCI), assessing novelty seeking, harm avoidance and reward dependence. Results: Congenital long QT syndrome mutation carriers had a higher harm avoidance (HA) than those representing the general population (2.77 vs. 2.61, p<.001, η²=0.011). Symptomatic and asymptomatic LQTS mutation carriers did not differ from one another in any of the three Cloninger''s temperament traits. HA was significantly higher in women (2.72 vs. 2.54, p<0.001 η²=0.017). Conclusions: LQTS mutation carriers may have higher stress proneness because of their high HA, which in turn may predispose them to the effects of environmental loading and thus increase the risk of arrhythmias. [Copyright &y& Elsevier]

Abstract: Objective: This study examined a longitudinal association between innate temperament and perceptions of long-term work stressors. Methods: The sample consisted of 276 men and 345 women (aged 30–45years in 2007) participating in the prospective population-based Cardiovascular Risk in Young Finns study. In 1992, temperament was self-assessed with the EAS questionnaire that assesses three temperamental traits: negative emotionality, activity, and sociability. Perceived work stressors were measured in 2001 and in 2007 using two models: Karasek''s demand/control-model in which a combination of high demands and low control results in job strain, and Siegrist''s Effort–reward imbalance (ERI) model. Results: The results showed that higher negative emotionality and lower sociability systematically predicted higher perceived job strain and ERI (P <.001). Activity predicted higher perceived ERI (P <.05). Activity did not predict perceived job strain, as it was related to both higher perceived demands and higher control. Conclusions: The results suggest that temperament may be a predisposing factor to the experiences of work stressors in adulthood. Although self-reported job strain and ERI are measures of job characteristics, they are affected by individual temperament. [Copyright &y& Elsevier]

Abstract: We examined the relationship between Cloninger’s temperament in adulthood, job strain and its components. There were 613 participants (273 men) aged 30–45years. Cloninger’s temperament scale () was used to measure temperament traits of novelty seeking (NS), harm avoidance (HA), reward dependence (RD) and persistence (P) in 1997 and in 2001. Job demands, job control, education and occupation were reported in 2001 and 2007. The results showed that low NS and high HA predicted higher long-term job strain. Higher NS, lower HA and higher P predicted higher long-term job control, and higher HA and higher P predicted higher long-term job demands. High RD predicted job strain only in 2001. Although job demands and job control mainly reflect characteristics of work environment, temperament tendencies seem to contribute to job strain and its components. [ABSTRACT FROM AUTHOR]

Abstract: Objective: The objective of this study was to prospectively examine whether parental socioeconomic position (SEP) and parental life satisfaction predict job strain in adulthood. Methods: The cohort comprised 755 participants from the ongoing Cardiovascular Risk in Young Finns Study. The parents reported their SEP and life satisfaction when the participants were aged 6–21 years. Eighteen years later at ages 24–39 years, the participants responded to a survey on job strain and its components, job control and job demands. Results: According to structural equation modeling, lower parental SEP and higher parental life dissatisfaction independently predicted increased adulthood job strain. Lower parental SEP also predicted lower educational attainment, which in turn was linked with higher job strain and lower job control. We found no gender differences in these predictive relationships. Conclusion: Parental SEP and parental life satisfaction are associated with job strain in adulthood, and the effect is partly mediated by education. These prospective data suggest that preemployment factors should be taken into account as potential confounders in future research on job strain–health associations. [Copyright &y& Elsevier]

Summary: Testosterone is the main male hormone that has been associated with various behavioral traits in humans and other animals. We investigated whether levels of total testosterone, free testosterone, and sex hormone binding globulin were associated with temperament traits in a population-based sample of Finnish men at two measurement times taken 6 years apart (n =686 in year 2001, n =727 in year 2007). Temperament was assessed using the Temperament and Character Inventory that consists of four temperament traits: novelty seeking, harm avoidance, reward dependence, and persistence. Higher levels of total and free testosterone were associated with higher novelty seeking (standardized B =0.103, p <0.001). This association was also observed in a longitudinal within-person analysis (B =0.084, p =0.008), suggesting that the association is not confounded by stable between-individual differences in other characteristics. Within-individual variation in total testosterone was associated with higher reward dependence, and higher levels of free testosterone were marginally associated with higher reward dependence. Reward dependence reflects the importance of social rewards to an individual. These results provide additional evidence for the stable and time-varying associations between testosterone and temperament in humans. [Copyright &y& Elsevier]

Objective: We compared the level of allostatic load (AL) between patients with major depressive disorder (MDD) and non-depressed controls using two definitions of AL: continuous AL scores (AL index) and clinically significant high AL (≥4). We examined whether MDD was associated with AL independent of basic socioeconomic (age, sex, cohabiting status and level of education) and lifestyle factors (smoking and alcohol use).Methods: The MDD patient sample consisted of 177 psychiatric outpatients (mean age 33.7, SD 10.7 years), who were recruited from the Department of Psychiatry at Kuopio University Hospital, Finland, in 2016-19. The non-depressed controls (n = 228, mean age 49.8, SD 10.1 years) lived in the municipality of Lapinlahti, Finland. Ten biomarkers were used to construct the two AL variables. These indicators were systolic and diastolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, glucose, creatinine, waist circumference, body mass index (BMI) and C-reactive protein (CRP).Results: The mean AL scores did not significantly differ between MDD patients (2.97) and non-depressed controls (3.12), thus it was not associated with MDD in univariate analysis. In multivariate models a higher AL index was associated with a 1.42 to 1.82 times higher likelihood of belonging to the MDD group. Furthermore, we found that high AL (i.e. AL ≥ 4) was associated with MDD, with the likelihood ranging between 2.27 and 2.96 compared with the non-depressed controls in multivariate models.Conclusions: Even young adult patients with MDD appear to display clinically significant, high AL compared with non-depressed controls. Thus, it is important to pay attention to the somatic health of depressed patients in addition to their mental health. [ABSTRACT FROM AUTHOR]

Compassion is linked with individual well-being, but its early origins, especially in the context of caregiving, remain poorly understood. Using a cohort of 323 Finnish individuals followed prospectively from the age of 3 to the age of 35, we examined whether care arrangements at ages 3 and 6 are associated with dispositional compassion in adulthood. Participants' parents provided data on early child care arrangements (home care, family care, or center-based care), and dispositional compassion was self-reported when the participants were 20, 24, and 35 years old. Multilevel modeling was applied to examine the association between early care and compassion, adjusting for the correlation between repeated measures within participants and several potential confounders. Our results showed that care arrangements at age 6, but not at age 3, were independently predictive of compassion later in life. When joint effects of different care arrangements that covered both ages 3 and 6 were examined, above average scores on adulthood compassion were observed among participants in home care at age 3 and center-based care at age 6. Characteristics of early care appear to contribute to the development of compassion with effects that persist into adult life. [ABSTRACT FROM AUTHOR]

We examined the association of perfectionism with depressive symptoms and tested whether psychological detachment from work would both mediate and moderate the association. The participants were 76 primary school teachers (87% female) who responded to measures of perfectionism (Multidimensional Inventory on Perfectionism in Sports adapted for teachers), psychological detachment from work (The Recovery Experience Questionnaire), and depressive symptoms (Beck Depression Inventory-II). Perfectionism comprised both adaptive and maladaptive dimensions. Adaptive perfectionism referred to striving for perfection, whereas maladaptive perfectionism involved negative reactions to imperfection and perceived pressure to be perfect. According to our results, negative reactions to imperfection were associated with higher depressive symptoms, and lower level of psychological detachment from work played a minor mediating role in the association. There was, however, no association between negative reactions to imperfection and higher depressive symptoms when detachment from work was high. Our findings suggest that striving for perfection and perceived pressure to be perfect might not contribute to depressive symptoms in teaching. Instead, teachers experiencing negative reactions to imperfection and low psychological detachment from work could be at risk for developing depressive symptoms. Finding ways to psychologically detach from work may benefit teachers characterized by negative reactions to imperfection. [ABSTRACT FROM AUTHOR]

We used genome wide expression (GWE) data of circulating blood cells and pathway analysis to investigate the inflammatory and other molecular pathways that may be associated with long-standing depressive symptoms. Participants were 607 women and 316 men (mean age 42 years) from the Young Finns Study who participated in three consecutive study phases in 2001, 2007 and 2012. Using Gene-set enrichment analyses (GSEA) we focused our analyses to pathways (available in MSigDB database) that are likely to affect immunological and inflammatory processes. GSEA were performed for blood cell GWE data in 2012. Depressive symptoms were assessed using a modified 21-item Beck Depression Inventory in each of the three study phases. Participants who scored in the top quartile of depressive symptoms in each of the three measurement points (n = 191) differed from other participants (n = 732) in several gene–set pathways related to inflammatory processes or immune-inflammatory signaling including interleukin (IL-1) pathway, and pathways related to various immuno-inflammatory processes, such as toll-like, the NEF protein, the nuclear factor kB, the kinase AKT and the mature B cell antigen receptor pathway (false discovery rates, FDRs < 0.12). The results provide novel genome wide molecular evidence that support the association between chronic depressive symptoms and altered immune-inflammatory regulation. [ABSTRACT FROM AUTHOR]

Abstract: Objective: Personality is a potential factor determining individual differences in body-weight change. The current study examines associations between personality traits and change in body-mass index (BMI) over six years. Method: The participants were 762 women and 648 men aged 24–39years at the base-line. Personality was assessed with the Temperament and Character Inventory (TCI). For calculating BMI, height and weight were assessed at a clinic. Results: Longitudinal analyses conducted with linear regressions showed that in men and women, higher Novelty seeking predicted higher BMI (p<.05), whereas lower Reward dependence predicted higher BMI in women (p<.05) when baseline BMI was taken into account. In addition, cross-sectional associations for several TCI traits were found in age and education adjusted analyses. In women, higher Self transcendence (p<.05) was associated with higher BMI. In men, higher Novelty seeking (p<.001) and Self transcendence (p<.01) and lower Self directedness (p<.01) and Cooperativeness (p<.05) were associated with higher BMI. In addition, analyses of variance were conducted for multidimensional trait profiles (trait combinations). Significant temperament profile related differences in BMI were found in all analyses in women. Associations with character profiles and in men were less consistent. Conclusion: The results give support for personality playing a role in weight gain. Knowledge on personality may be used for motivating weight loss and designing weight management interventions. [Copyright &y& Elsevier]

Abstract: The current study examines associations between self- and teacher-rated temperament traits (activity, inhibition, negative emotionality, persistence, distractibility, and mood) and mathematics grades. The sample includes 310 ninth grade students (mean age 15.0) from several schools in Finland. Analyses were conducted with multilevel modeling. Except for mood, all temperament traits were associated with math grades independent of motivation and standardized cognitive ability test performance (intelligence). However, some relations were found only for teacher-reports and some only for student-reports. The rater dependent differences are of interest and emphasize a need for data from multiple raters before drawing conclusions on how temperament relates to school grades. The results suggest that temperament should be taken into account in schooling and in teacher education. [Copyright &y& Elsevier]

Abstract: We examined two alternative hypotheses on the association between low socioeconomic status (SES) and depressive symptoms: social causation and health selection. The latent growth curve (LGC) approach was used to examine trajectories of change in depressive symptoms over a period of 15 years in a dataset (the Young Finns study) consisting of a nationally representative sample of adolescents and young adults (n = 1613). Depressive symptoms were examined at four examination phases between 1992 and 2007. SES was measured as parental SES childhood (baseline of the study in 1980) and as the participants own SES in 2007 when the participants had reached adulthood and were between 30 and 45 years of age. The level of depressive symptoms was associated (r = −.14) with a slower decrease in symptoms during follow-up. Lower age, male gender, higher parental occupational grade but not parental income and lower negative emotionality in childhood were associated with a lower level of depressive symptoms. Higher age was also associated with a slower decrease in depressive symptoms. A lower level of depression and faster decrease in depressive symptoms were associated with a higher socioeconomic position in adulthood. A similar pattern was found in the relationship between the level of depression and income in adulthood. We concluded that the effect of childhood SES on depressive symptoms diminishes over time, but a higher level of, and especially faster decline of, depressive symptoms predicts the adulthood occupational SES gradient. [Copyright &y& Elsevier]