16 results on '"Hagay, Zion"'
Search Results
2. Synchronization of the factors critical for diabetic teratogenesis: an in vitro model
- Author
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Reece, E. Albert, Wiznitzer, Arnon, Homko, Carol J., Hagay, Zion, and Wu, Ying King
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Diabetes in pregnancy -- Complications ,Birth defects -- Risk factors ,Health - Abstract
Pregnancies complicated by diabetes may result in fetal birth defects only if poor blood sugar control occurs at specific times of fetal development. Researchers induced high blood sugar levels in pregnant rats to determine their effect on fetal development. High blood sugar levels caused defects in fetal development during days 10 and 11 of the rat pregnancy. A 20% rate of defects occurred at blood sugar levels double the normal concentration, a 50% rate of defects at blood sugar levels four times the norm, and a 100% rate of defects at blood sugar levels six times the norm. High blood sugar levels had to be sustained for at least two hours for defects to occur. Defects may not occur if high blood sugar levels are not present during critical periods of development.
- Published
- 1996
3. Congenital cytomegalovirus infection: A long-standing problem still seeking a solution
- Author
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Hagay, Zion J., Biran, Galya, Ornoy, Asher, and Reece, E.Albert
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Disease transmission -- Health aspects ,Virus diseases -- Health aspects ,Health - Abstract
Byline: Zion J. Hagay, Galya Biran, Asher Ornoy, E.Albert Reece Keywords: Congenital cytomegalovirus infection; prenatal diagnosis; serologic tests; mass screening Abstract: OBJECTIVE: The purpose of this study was to review the accuracy of current tests used for the diagnosis of in utero cytomegalovirus infection and to discuss the potential value of preconceptional and postconceptional screening programs for prevention of congenital infection. STUDY DESIGN: A computer-assisted search was performed for relevant English language publications between 1987 and 1994. We identified 119 cases of suspected intrauterine cytomegalovirus infection in which either amniotic fluid or fetal blood had been analyzed antenatally. RESULTS: Congenital cytomegalovirus infection affects 0.5% to 2.5% of all newborns. The rate of transmission to the fetus after primary infection during pregnancy ranges from 15% to 50%. Of the fetuses infected in utero, 10% exhibit congenital cytomegalovirus syndrome. Evaluation of 119 cases of suspected infection has shown that polymerase chain reaction and cultures of amniotic fluid are the most reliable tests for prenatally determining the presence of viral particles. However, efficacy of routine antenatal screening in reducing the rate of fetal disease is limited. CONCLUSION: It is concluded that at present the accuracy of tests used for the diagnosis of in utero cytomegalovirus infection is undetermined. Serologic screening of all pregnant women is of limited value and at present is not recommended. (AM J OBSTET GYNECOL 1996;174:241-5.) Author Affiliation: Rehovot and Jerusalem, Israel, and Philadelphia, Pennsylvania Article History: Received 15 December 1994; Revised 24 March 1995; Accepted 4 May 1995 Article Note: (footnote) [star] From the Departments of Obstetrics and Gynecology, Kaplan Hospital,a the Jerusalem Institute of Child Development and Laboratory of Teratology, The Hebrew University, Haddasah Medical School, b and Temple University School of Medicine. , [star][star] Reprint requests: Zion J. Hagay, MD, Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel., a 0002-9378/96 $5.00 + 0 6/1/66061
- Published
- 1996
4. Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos
- Author
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Hagay, Zion J., Weiss, Yael, Zusman, Igor, Peled-Kamar, Mira, Reece, E. Albert, Eriksson, Ulf J., and Groner, Yoram
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Diabetes in pregnancy -- Complications ,Superoxide dismutase -- Measurement ,Fetus -- Abnormalities ,Health - Abstract
Higher than normal levels of the copper zinc superoxide dismutase gene in fetuses may protect them from developing abnormally as a result of diabetes in their mothers. Copper zinc superoxide dismutase is an enzyme that may rid the body of oxygen free radicals, which are overproduced in connection with diabetes mellitus and may cause fetuses to form abnormally. Researchers induced diabetes in mice that were pregnant with embryos either with the human copper zinc superoxide dismutase gene or without it. Mouse embryos with the copper zinc superoxide dismutase gene did not experience growth reductions, had a low rate of malformation and a low rate of fetal death, whereas embryos without the gene were more likely to be small, malformed, or to die before the end of pregnancy.
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- 1995
5. Fetal Doppler and behavioral responses during hypoglycemia induced with the insulin clamp technique in pregnant diabetic women
- Author
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Reece, E. Albert, Hagay, Zion, Roberts, Alistair B., DeGennaro, Nancy, Homko, Carol J., Connoly-Diamond, Meredith, Sherwin, Robert, Tamborlane, William V., and Diamond, Michael P.
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Diabetes in pregnancy -- Physiological aspects ,Fetus -- Health aspects ,Hypoglycemia -- Physiological aspects ,Health - Abstract
Brief episodes of moderate low blood sugar do not appear to affect the fetus of insulin-dependent diabetic women. While it is known that tight metabolic control improves pregnancy outcomes among insulin-dependent diabetics, this results in frequent episodes of hypoglycemia. Ten insulin-dependent diabetic women at gestational ages ranging from 27 to 37 weeks underwent a controlled reduction of blood sugar by infusing insulin. Maternal blood sugar was reduced to 45 mg/dl for 40 minutes. Electronic fetal monitoring and ultrasound imaging evaluated fetal heart rate, fetal practice breathing movements (a measure of fetal well-being), and fetal limb movements. Placental perfusion was evaluated via Doppler ultrasound studies as well. No adverse fetal effects were found. The effects of long-term or severe hypoglycemia on the fetus has not been studied.
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- 1995
6. A controlled trial of self-nonstress test versus assisted nonstress test in the evaluation of fetal well-being
- Author
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Reece, E. Albert, Hagay, Zion, Garofalo, Jill, and Hobbins, John C.
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Fetal heart rate monitoring -- Methods ,Ambulatory electrocardiography -- Usage ,Health - Abstract
OBJECTIVE: New portable devices have become available for home monitoring of fetal heart rates; these devices have the potential to immediately transmit these tracings to a medical facility. The null hypothesis of this study is the inability of mothers to perform their own nonstress tests (self-nonstress tests) and that such tests are not comparable to those performed by professional medical personnel (assisted nonstress tests). STUDY DESIGN: The feasibility of maternal self-testing was established in 50 high-risk patients followed by a controlled clinical trial conducted in 60 patients. The latter study represents the first controlled trial in which patients performed self-nonstress tests at their homes and transmitted the tracings via telecommunication to our perinatal unit. In all cases these patients came to our hospital within 60 minutes after the self-nonstress tests to have a perinatal nurse perform a second nonstress test. The pairs of self and assisted fetal heart rate tracings were independently reviewed by two investigators. RESULTS: The self and assisted tracing pairs were judged satisfactory for interpretation in 100% and 90%, respectively; self and assisted were interpreted by each examiner to be nonreactive in 20% and 14%, respectively. However, both examiners were unable to distinguish between tracings generated by assisted nonstress and self-nonstress tests. Furthermore, cost analysis revealed an estimated twofold savings with self-nonstress testing compared with the assisted nonstress test. CONCLUSION: Self-nonstress testing is a reliable and accurate method of antepartum fetal heart rate testing. This method of fetal assessment not only introduces a new approach to fetal surveillance with added convenience to patients, but may also significantly reduce medical cost without compromising the results of fetal testing. (Am J Obstet Gynecol 1992;166:489-92.)
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- 1992
7. Amniotic fluid white blood cell count: a rapid and simple test to diagnose microbial invasion of the amniotic cavity and predict preterm delivery
- Author
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Romero, Roberto, Quintero, Ruben, Nores, Jose, Avila, Cecilia, Mazor, Moshe, Hanaoka, Shuichi, Hagay, Zion, Merchant, Lydia, and Hobbins, John C.
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Premature labor -- Risk factors ,Amniotic fluid ,Leukocytes ,Pregnancy, Complications of -- Diagnosis ,Health - Abstract
Accurate, rapid diagnosis of the presence of microbes in the amniotic fluid is essential to prevent complications, which can include premature delivery and a host of problems for both mother and infant. However, many medical centers that use amniocentesis (sampling of amniotic fluid) analyze their samples using the Gram stain, a microbiological method that can fail to detect microorganisms in as many as half the cases in which they are present. In this study, the amniotic fluid white blood cell count was evaluated as a method of diagnosing microbial invasion. Amniotic fluid samples were taken from 195 patients undergoing preterm labor with a single fetus; the patients underwent treatment with tocolytic agents (to inhibit uterine contractions). The samples were evaluated with the Gram stain and in tissue culture, as well as for concentrations of white blood cells. Pregnancies progressed to term in 84 cases (43 percent) and microorganisms were present in 25 cases (12.8 percent). Those with positive culture results had higher levels of white blood cells than those with negative results. The sensitivity of the white blood cell count (extent to which that test correctly identified the infected women) was 80 percent; and its specificity (extent to which the test correctly diagnosed the absence of infection) was 87.6 percent. The sensitivity of the white blood cell count was higher than that of the Gram stain, but its specificity was lower. On the whole, the amniotic fluid white blood cell count is sensitive, simple, and inexpensive. Patients with levels equal to or less than 50 cells per cubic millimeter were at risk for premature delivery. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1991
8. Conservative management of ovarian cystic teratoma during pregnancy and labor
- Author
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Caspi, Benjamin, Levi, Roni, Appelman, Zvi, Rabinerson, David, Goldman, Gil, and Hagay, Zion
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Teratoma -- Health aspects ,Ovaries -- Cysts ,Health - Abstract
Women with ovarian cystic teratoma can probably become pregnant and deliver a healthy baby. In a study of 49 women with this benign tumor, 63 out of 68 pregnancies were not affected by the tumor, and the tumor did not grow bigger during the pregnancy.
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- 2000
9. Eradication of Ureaplasma urealyticum from the amniotic fluid with transplacental antibiotic treatment
- Author
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Romero, Roberto, Hagay, Zion, Nores, Jose, Sepulveda, Waldo, and Mazor, Moshe
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Ureaplasma urealyticum -- Drug therapy ,Amniotic fluid -- Analysis ,Chorioamnionitis -- Care and treatment ,Antibiotics -- Health aspects ,Premature rupture of membranes -- Care and treatment ,Health - Abstract
Ureaplasma urealyticum was isolated from the amniotic fluid of a patient with preterm premature rupture of membranes at 24 weeks. A second amniocentesis performed 48 hours later indicated an increase in the number of neutrophils in the amniotic fluid. Treatment with erythromycin, ampicillin, gentamicin, and clindamycin was instituted for a period of 6 days. Amniotic fluid analysis from a third amniocentesis performed 24 hours after discontinuation of antibiotic treatment revealed only a few white blood cells and was negative for microorganisms. The pregnancy continued for 22 days after admission, at which time spontaneous labor began. The neonate survived with no sequelae and had negative blood cultures. Antibiotic treatment was associated with eradication of Ureaplasma urealyticum from the amniotic cavity, pregnancy prolongation, and neonatal survival. (Am J Obstet Gynecol 1992;166:618-20.)
- Published
- 1992
10. Preterm delivery: a risk factor for retained placenta
- Author
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Romero, Roberto, Hsu, Yu Chiung, Athanassiadis, Apostolos P., Hagay, Zion, Avila, Cecilia, Nores, Jose, Roberts, Alistair, Mazor, Moshe, and Hobbins, John C.
- Subjects
Placenta -- Risk factors ,Placenta -- Causes of ,Fetal membranes ,Placenta -- Physiological aspects ,Premature labor -- Complications ,Health - Abstract
Retained placenta is a placenta that does not spontaneously separate from the uterus within 30 minutes after delivery of the infant. Retained placenta appears to occur at a higher rate in preterm deliveries (between 20 and 36 gestational weeks) than in term deliveries. Since approximately one-fifth of the women who deliver preterm infants also have microbiological evidence of bacteria in the amniotic fluid (in which the fetus floats), it is possible that retention of the placenta is associated with infection. To learn more about this, medical records were reviewed from 231 preterm vaginal deliveries and 561 term vaginal deliveries (the latter served as controls) at one medical facility. The preterm patients had undergone amniocentesis (removal of a sample of amniotic fluid) upon admission to the hospital for evaluation of possible microorganism content. One hundred twenty-five women had preterm labor with intact membranes (the membranes that surround the fetus) and 106 had premature rupture of membranes (PROM). Slightly more than 9 percent of the women with preterm vaginal delivery had retained placentas, compared with slightly more than 1 percent of the women with term deliveries, a statistically significant difference. No difference in the proportion of retained placentas was found between the PROM and non-PROM groups. The greater incidence of retained placenta in preterm births was not associated with either a positive result for microorganisms or with the presence of chorioamnionitis (inflammation of the amniotic membranes). The results show that preterm delivery is associated with retained placenta, but suggest that intrauterine infection and inflammation are not associated with retention. Other possible explanations are discussed. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1990
11. A randomized trial comparing a 30-mL and an 80-mL Foley catheter balloon for preinduction cervical ripening.
- Author
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Levy, Roni, Kanengiser, Bibi, Furman, Boris, Ben Arie, Alon, Brown, Dov, and Hagay, Zion J.
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INDUCED labor (Obstetrics) ,PREGNANCY complications ,CATHETERS ,DRUG delivery devices ,CERVIX uteri - Abstract
Objectives: The purpose of this study was to compare the efficacy of cervical ripening with 2 Foley catheter balloon volumes. Study design: Pregnant women admitted for induction of labor with a term singleton gestation were randomly assigned for cervical ripening by a balloon inflated with 30 mL or 80 mL of sterile saline. Results: Two hundred and three women were included in the analysis. Ripening of the cervix with the larger balloon volume was associated with a significantly higher rate of post-ripening dilatation of 3 cm or more (76.0% vs 52.4%, P < .001). In primiparous women, the larger balloon volume resulted in a significantly higher rate of deliveries by 24 hours (71.4% vs 49%, P < .05), and a significantly less requirement of augmentation with oxytocin (69.3% vs 90.4%, P < .05). Conclusion: Ripening of the unfavorable cervix in primiparous women with a Foley catheter balloon inflated with 80 mL provided effective more dilatation, faster labor, and decreased need for oxytocin than with a balloon inflated with 30 mL of sterile saline. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
12. Laparoscopic hysterectomy versus total abdominal hysterectomy: A comparative study
- Author
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Vaisbuch, Edi, Goldchmit, Chen, Ofer, Dganit, Agmon, Arnon, and Hagay, Zion
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HYSTERECTOMY , *HEMOGLOBIN polymorphisms , *STERILIZATION of women , *UTERINE surgery - Abstract
Abstract: Objective: The objective of this study was to compare the intraoperative and short-term postoperative complications of laparoscopic hysterectomy and total abdominal hysterectomy. Study design: Retrospective study of 167 women who had laparoscopic hysterectomy and 119 women who had total abdominal hysterectomy. For assessing the learning curve, the laparoscopic hysterectomies were further subdivided to the first 30 hysterectomies and the later hysterectomies. For data analysis Student''s t-test, χ 2-test and Fisher''s exact test were used. Results: There were no statistically significant differences between the two groups for age, body mass index, previous abdominal surgery, uterine weight, first postoperative day hemoglobin drop, blood transfusion and major or minor complications rate. Operation time was significantly longer for laparoscopic than abdominal hysterectomy (156±40 and 91.2±33min, respectively; P <0.001) but the length of hospital stay was significantly shorter (3.9 and 6.55 days, respectively; P <0.001). The conversion rate of laparoscopic hysterectomy was 1.8% (three cases). Conclusions: Laparoscopic hysterectomy can be safely done even during the learning curve with a low and reasonable complication rate, and a shorter hospital stay but with longer operation time. As experience is gained the operation time, complication rate and hospital stay are decreased. [Copyright &y& Elsevier]
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- 2006
- Full Text
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13. The malignant potential of endometrial polyps
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Ben-Arie, Alon, Goldchmit, Chen, Laviv, Yosef, Levy, Roni, Caspi, Benjamin, Huszar, Monica, Dgani, Ram, and Hagay, Zion
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POLYPS , *HYSTEROSCOPY , *TUMORS , *ENDOSCOPY - Abstract
Objectives: To determine the pre-malignant and malignant potential of endometrial polyps and to assess whether different clinical parameters are associated with malignancy in the polyps. Study design: Four hundred and thirty consecutive cases of hysteroscopic diagnosis of endometrial polyp were retrieved. The medical records, preoperative vaginal sonography results and histopathology findings were reviewed. Statistical analysis was performed. Results: Hysteroscopy truly identified endometrial polyps in 95.7% of the cases. In 11.4% cases, hyperplasia without atypia was found in the endometrial polyp. In 3.3 and 3.0% of women pre-malignant or malignant conditions were found in the polyp. Older age, menopause status and polyps larger than 1.5 cm were associated with significant pre-malignant or malignant changes, although the positive predictive value for malignancy was low. All the malignant polyps were diagnosed only in postmenopausal women. The presence of postmenopausal or irregular vaginal bleeding, was not a predictor of malignancy in the polyp. Conclusions: Postmenopausal women with endometrial polyps are at increased risk of malignancy in the polyp. Those patients, whether symptomatic or not should be evaluated by hysteroscopic resection of the polyps. Asymptomatic premenopausal patients with polyps smaller than 1.5 cm can be observed. [Copyright &y& Elsevier]
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- 2004
- Full Text
- View/download PDF
14. A randomised comparison of early versus late amniotomy following cervical ripening with a Foley catheter.
- Author
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Levy, Roni, Ferber, Asaf, Ben-Arie, Alon, Paz, Beatrice, Hazan, Ynon, Blickstein, Isaac, and Hagay, Zion J.
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PREGNANCY , *LABOR (Obstetrics) , *OBSTETRICS - Abstract
: ObjectivesRipening of the cervix with a Foley catheter commonly results in cervical dilatation without contractions. We examined the outcome of labour in women who underwent induction of labour using a Foley catheter, followed by either 1. early amniotomy, or 2. augmentation of labour by oxytocin and late amniotomy: DesignProspective randomised clinical trial: SettingLabour and delivery ward of a university teaching hospital: ParticipantsPregnant women ≥38 weeks of a singleton gestation, who had had no prior caesarean section: MethodsAll women underwent cervical ripening using a Foley catheter. Following removal of the catheter, women were randomly assigned to either early (n = 80) or late amniotomy (n = 88).Main outcome measures Comparison of mode of delivery and duration of labour between the two groups: ResultsThe rate of caesarean section was significantly higher in the early amniotomy group compared with the late amniotomy group (25% vs 7.9%; relative risk 1.74; 95% CI 1.3 – 2.34). The increase in caesarean section rate was due primarily to dystocia (15% vs 3.3%; relative risk 1.8; 95% CI 1.32 – 2.45). When excluding caesarean deliveries, no significant difference was found in duration of labour between the groups (8.3 hours (3.8) vs 7.7 hours (2.9)): ConclusionsIn women who undergo cervical ripening with a Foley catheter, augmentation of labour by oxytocin followed by amniotomy during active labour results in a lower rate of caesarean delivery for dystocia [ABSTRACT FROM AUTHOR]
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- 2002
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15. Head pushing versus reverse breech extraction in cases of impacted fetal head during Cesarean section
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Levy, Roni, Chernomoretz, Tamara, Appelman, Zvi, Levin, Dan, Or, Yuval, and Hagay, Zion J.
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CESAREAN section , *DISEASES , *INFANTS , *DELIVERY (Obstetrics) - Abstract
Abstract: Objective:: To compare maternal and neonatal morbidity associated with two methods to extract the impacted fetal head during Cesarean delivery. Study design:: We retrospectively analyzed cases with difficult extraction of the impacted fetal head during Cesarean section. We compared maternal and neonatal outcomes between cases that were delivered by head extraction following pushing through the vagina (‘push’ method) and those that were delivered by the reverse breech technique (‘pull’ method). Results:: We reviewed 3105 Cesarean section reports. Difficult extraction necessitating the ‘push’ or ‘pull’ methods was noted in 48 (1.5%) instances. Women that were delivered by the ‘pull’ method had significantly lower rate of postpartum fever (5% versus 46%; odds ratios, 0.06; 95% confidence intervals, 0.007–0.51) and extensions of the uterine incision (15% versus 50%; odds ratio, 0.17; 95% CI, 0.04–0.74) compared to those that were delivered by the ‘push’ method. Neonatal outcomes were good in all cases. Conclusions:: In cases with difficult extraction of the impacted fetal head during Cesarean section, ‘pull’ method may result in lower maternal morbidity compared to the traditional ‘push’ method. [Copyright &y& Elsevier]
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- 2005
- Full Text
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16. OP-17 - Tea Extracts-induced Liver Injury: Lipotoxic Interaction Between Lipids and Polyphenols.
- Author
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Tirosh, Oren, Hirsch, Nina, Konstantinov, Anya, Anavi, Sarit, Aronis, Anna, Hagay, Zion, and Madar, Zecharia
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GREEN tea , *POLYPHENOLS , *LIVER injuries - Abstract
Green tea polyphenol extracts (GTE) are sold commercially as cholesterol-reducing agents and for weight reduction however, they have also been reported to be hepatotoxic. Our results from both in vitro and in vivo studies indicate that green tea polyphenols can potentiate liver injury after and during treatment with high cholesterol diet to induce experimental NASH. Eight week old male C57BL mice (n=32) were fed for 6 weeks with one of the following diets: Control diet (Con); Con +1% w/w polyphenols from green tea extract (Con+GTE); High cholesterol diet, Con+ 1% cholesterol+ 0.5% cholate w/w (HCD); HCD + 1 % polyphenols w/w (HCD+GTE). Hepatic steatosis, oxidative and inflammatory markers and bile acid synthesis pathways were measured. GTE enhanced hepatic steatosis but only in animals exposed to the high cholesterol diet. In HCD treated animals GTE elevated blood levels of liver enzymes SGOT, SGPT, and bile acids. Inflammatory and oxidative markers in the liver were also significantly increased including liver mRNA expression of TNF-alpha, IL-6, SAA1, SAA2, iNOS and levels of 4-hydroxynonenal protein adducts. The mechanism of action for GTE/cholesterol hepatotoxicity was found to be related to alteration in bile acids synthesis pathways. This study shows that liver injury in the presence of lipids could be the reason for weigh loss by high dose of polyphenols. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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