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A new and efficient protocol for the conversion of aldehyde into nitriles by modified Schmidt reaction. The reaction is carried out under solvent free condition using sodium azide as a source of nitrogen and catalysed by p -toluene sulphonic acid in presence of silica surface with no side product. This transformation gives good to excellent yield for numerous aromatic, aliphatic and heterocyclic nitriles using very simple reagent. This method has avoided the use of transition metal catalyst, toxic cyanide, hazardous solvent and offers a greener, simple and environment friendly procedure. [ABSTRACT FROM AUTHOR]

A versatile, robust and efficient strategy for the synthesis of vast range of highly functionalized 5-substituted 1 H -tetrazole derivatives by using one pot three-component synthesis from various aldehydes, hydroxylamine hydrochloride and sodium azide in presence of a catalytic amount of ceric ammonium sulphate, a non toxic, easily available, inexpensive, unexplored and reusable catalyst is reported. This one-pot synthesis has several advantages such as mild reaction conditions, shorter reaction time, low catalyst loading, good to moderate yields and functional group tolerance making this methodology practically feasible. The synthesized compounds were characterized by 1 H NMR, 13 C NMR and HRMS. [ABSTRACT FROM AUTHOR]

Fe 3 O 4 -CTAB NPs have been applied as a competent catalyst for one-pot synthesis of nitriles directly from aldehydes. The present investigation describes the synthesis of nitriles by combination of aromatic/aliphatic/heterocyclic aldehydes and hydroxylamine hydrochloride in the presence of iron oxide nanocatalyst in DMF under reflux condition. Fe 3 O 4 -CTAB NPs were prepared by reported method and characterized by FE-SEM, TEM, and XRD analysis. The amount of Fe in Fe 3 O 4 -CTAB was quantified by Atomic Absorption Spectroscopy (AAS). The protocol endow with excellent yield of products along with simple reaction set up and economically adept alternative approach. [ABSTRACT FROM AUTHOR]