19 results on '"Gonzalez, Jeffrey S."'
Search Results
2. Emotional distress, self-management, and glycemic control among participants enrolled in the glycemia reduction approaches in diabetes: A comparative effectiveness (GRADE) study
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Gonzalez, Jeffrey S., Krause-Steinrauf, Heidi, Bebu, Ionut, Crespo-Ramos, Gladys, Hoogendoorn, Claire J., Naik, Aanand D., Waltje, Andrea, Walker, Elizabeth, Ehrmann, Dominic, Brown-Friday, Janet, and Cherrington, Andrea
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- 2023
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3. Diabetes risk scores for Hispanics living in the United States: A systematic review
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Juarez, Lucia D., Gonzalez, Jeffrey S., Agne, April A., Kulczycki, Andrzej, Pavela, Gregory, Carson, April P., Shelley, John P., and Cherrington, Andrea L.
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- 2018
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4. Within-person relationships of sleep duration with next-day stress and affect in the daily life of adults with Type-1 diabetes.
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Jin, Haomiao, Gonzalez, Jeffrey S., Pyatak, Elizabeth A., Schneider, Stefan, Hoogendoorn, Claire J., Hernandez, Raymond, Lee, Pey-Jiuan, and Spruijt-Metz, Donna
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SLEEP duration , *ECOLOGICAL momentary assessments (Clinical psychology) , *TYPE 1 diabetes , *SLEEP interruptions , *AFFECT (Psychology) , *EVERYDAY life - Abstract
The objective of this study is to examine the within-person relationships between sleep duration and next-day stress and affect in the daily life of individuals with T1D. Study participants were recruited in the Function and Emotion in Everyday Life with Type 1 Diabetes (FEEL-T1D) study. Sleep duration was derived by synthesizing objective (actigraphy) and self-report measures. General and diabetes-specific stress and positive and negative affect were measured using ecological momentary assessment. Multilevel regression was used to examine the within-person relationships between sleep duration and next-day stress and affect. Cross-level interactions were used to explore whether gender and baseline depression and anxiety moderated these within-person relationships. Adults with T1D (n = 166) completed measurements for 14 days. The average age was 41.0 years, and 91 participants (54.8%) were female. The average sleep duration was 7.3 h (SD = 1.2 h). Longer sleep was significantly associated with lower general stress (p < 0.001) but not diabetes-specific stress (p = 0.18) on the next day. There were significant within-person associations of longer sleep with lower levels on next-day negative affect (overall, p = 0.002, disappoint, p = 0.05; sad, p = 0.05; tense, p < 0.001; upset, p = 0.008; anxious, p = 0.04). There were no significant associations with positive affect. Examination of the interaction effects did not reveal significant differential relationships for men and women and for individuals with and without depression or anxiety at baseline. Findings from this study suggest optimizing sleep duration as an important interventional target for better managing general stress and improving daily emotional wellbeing of individuals with T1D. • Sleep disturbances are common in type 1 diabetes (T1D). • Longer sleep can improve stress and negative affect on the next day. • Sleep duration is a modifiable target to improve functioning for T1D. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Probing for depression and finding diabetes: a mixed-methods analysis of depression interviews with adults treated for type 2 diabetes
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Tanenbaum, Molly L., Ritholz, Marilyn D., Binko, Deborah H., Baek, Rachel N., Erica Shreck, M.S., and Gonzalez, Jeffrey S.
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- 2013
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6. “Knowing That You’re Not the Only One”: Perspectives on Group-Based Cognitive-Behavioral Therapy for Adherence and Depression (CBT-AD) in Adults With Type 1 Diabetes.
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Esbitt, Sabrina A., Batchelder, Abigail W., Tanenbaum, Molly L., Shreck, Erica, and Gonzalez, Jeffrey S.
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COGNITIVE therapy ,DEPRESSION in adolescence ,TYPE 1 diabetes ,BLOOD sugar ,MEDICAL research ,PATIENTS ,THERAPEUTICS - Abstract
Depression and illness-specific distress are more common among adults with Type 1 diabetes (T1DM) than the general population and have been associated with poorer control of blood glucose and increased risk for serious diabetes-related complications. Treatment nonadherence has also been associated with depressive symptoms and diabetes-related distress, and has repeatedly been suggested as an important modifiable behavioral pathway linking depression and diabetes outcomes. The present study reports on the feasibility and acceptability of a pilot intervention using group-based cognitive-behavioral therapy to improve treatment adherence among adults with T1DM and elevated levels of diabetes-related distress or depressive symptoms. We describe the components of the intervention and utilize qualitative data along with descriptive outcome data. Our findings suggest that participation in the group was acceptable and associated with reductions in depressive symptoms and diabetes-specific distress. Challenges to feasibility and future directions are discussed. [ABSTRACT FROM AUTHOR]
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- 2015
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7. The ARMS-D out performs the SDSCA, but both are reliable, valid, and predict glycemic control.
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Mayberry, Lindsay S., Gonzalez, Jeffrey S., Wallston, Kenneth A., Kripalani, Sunil, and Osborn, Chandra Y.
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GLYCEMIC index , *TREATMENT of diabetes , *PSYCHOMETRICS , *SELF-evaluation , *OUTPATIENT medical care , *INSULIN therapy - Abstract
Abstract: Aims: The Adherence to Refills and Medications Scale (ARMS) has been associated with objective measures of adherence and may address limitations of existing self-report measures of diabetes medication adherence. We modified the ARMS to specify adherence to diabetes medicines (ARMS-D), examined its psychometric properties, and compared its predictive validity with HbA1C against the most widely used self-report measure of diabetes medication adherence, the Summary of Diabetes Self-Care Activities medications subscale (SDSCA-MS). We also examined measurement differences by age (<65 vs. ≥65 years) and insulin status. Methods: We administered self-report measures to 314 adult outpatients prescribed medications for type 2 diabetes and collected point-of-care HbA1C. Results: One of the 12-item ARMS-D items was identified as less relevant to adherence to diabetes medications and removed. The 11-item ARMS-D had good internal consistency reliability (α =0.86), maintained its factor structure, and had convergent validity with the SDSCA-MS (rho = −0.52, p <0.001). Both the ARMS-D (β =0.16, p <0.01) and the SDSCA-MS (β =−0.12, p <0.05) independently predicted HbA1C after adjusting for covariates, but this association did not hold among participants ≥65 years in subgroup analyses. There were no differences in ARMS-D or SDSCA-MS scores by insulin status, but participants on insulin reported more problems with adherence on two ARMS-D items (i.e., feeling sick and medicine costs). Conclusions: The ARMS-D is a reliable and valid measure of diabetes medication adherence, and is more predictive of HbA1C than the SDSCA-MS, but takes more time to administer. The ARMS-D also identifies barriers to adherence, which may be useful in research and clinical practice. [Copyright &y& Elsevier]
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- 2013
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8. CBT for Medication Adherence and Depression (CBT-AD) in HIV-Infected Patients Receiving Methadone Maintenance Therapy.
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Soroudi, Nafisseh, Perez, Giselle K., Gonzalez, Jeffrey S., Greer, Joseph A., Pollack, Mark H., Otto, Michael W., and Safren, Steven A.
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FEASIBILITY studies ,HIV-positive persons ,MENTAL depression ,BEHAVIOR therapy - Abstract
Abstract: For individuals with HIV who are current or former injection drug users, depression is a common, distressing condition that can interfere with a critical self-care behavior—adherence to antiretroviral therapy. The present study describes the feasibility and outcome, in a case series approach, of cognitive behavioral therapy to improve adherence and depression (CBT-AD) among individuals with HIV and depression undergoing methadone maintenance treatment for heroin dependence. CBT-AD integrates cognitive behavioral therapy for depression with our intervention for improving adherence to antiretroviral therapy for HIV (Life-Steps; [Safren, S. A., Otto, M. W., Worth, J., Salomon, E., Johnson, W., Mayer, K., et al. (2001). Two strategies to increase adherence to HIV antiretroviral medication: Life-Steps and medication monitoring. Behavioral Research and Therapy, 39, 1151–1162]). Specifically, in CBT-AD, patients first receive a cognitive behavioral intervention focusing on improving skills related to medication adherence. Each of the subsequent CBT modules (activity scheduling, cognitive restructuring, problem-solving training, and relaxation training/diaphragmatic breathing) is designed to address both self-care/adherence behaviors as well as depression. The process and outcome with 4 cases suggest that the treatment was feasible and acceptable and was generally associated with improvements. This case series provides an example of how cognitive behavioral therapists can integrate the treatment of depression with the enhancement of critical self-care behaviors in the context of highly complex, medical and psychiatric comorbidity. [Copyright &y& Elsevier]
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- 2008
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9. Personality, quality of life and HAART adherence among men and women living with HIV/AIDS
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Penedo, Frank J., Gonzalez, Jeffrey S., Dahn, Jason R., Antoni, Mike, Malow, Robert, Costa, Paul, and Schneiderman, Neil
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HIV , *AIDS , *QUALITY of life - Abstract
Very few studies have documented relations between personality traits and quality of life among individuals living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). Some have shown that poor perceived quality of life as determined by a sense of purpose may be associated with inadequate adherence to highly active antiretroviral treatment (HAART) in this population. Although adequate HAART adherence is critical to achieve the full therapeutic effects of newly and highly effective regimens, very little is known of how both personality factors and HIV-specific quality of life may impact adherence to these medication regimens. This study evaluated relations among personality traits, quality of life and HAART adherence among 116 men and women living with HIV/AIDS. Results showed that personality traits such as neuroticism were significantly associated with poorer quality of life, whereas conscientiousness and extraversion were associated with better quality of life. In contrast, personality traits were not directly related to HAART adherence. Both higher overall functioning and lower medication worries scores were significantly associated with HAART adherence. Findings suggest that personality traits are associated with HIV-specific quality of life on the one hand, and that HIV-specific quality of life is related to HAART adherence on the other. Future studies assessing the efficacy of psychosocial interventions in improving quality of life and HAART adherence should consider the role of personality traits in promoting better quality of life. [Copyright &y& Elsevier]
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- 2003
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10. Design and methods of NYC care calls: An effectiveness trial of telephone-delivered type 2 diabetes self-management support.
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Gonzalez, Jeffrey S., Hoogendoorn, Claire J., Linnell, Jill, Fishman, Sarah, Jonas, Victoria, Pham-Singer, Hang, Schechter, Clyde B., Walker, Elizabeth A., and Wu, Winfred Y.
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TYPE 2 diabetes , *PATIENT compliance , *GLYCEMIC control , *RANDOMIZED controlled trials , *TELEPHONE calls - Abstract
Although problems with type 2 diabetes (T2D) self-management and treatment adherence often co-occur with emotional distress, few translatable intervention approaches are available that can target these related problems in primary care practice settings. The New York City (NYC) Care Calls study is a randomized controlled trial that tests the effectiveness of structured support for diabetes self-management and distress management, delivered via telephone by health educators, in improving glycemic control, self-management and emotional well-being among predominantly ethnic minority and socioeconomically disadvantaged adults with suboptimally controlled T2D. English- and Spanish-speaking adults treated for T2D in NYC primary care practices were recruited based on having an A1C ≥ 7.5% despite being prescribed medications for diabetes. Participants (N = 812) were randomly assigned to a telephonic intervention condition with a stepped protocol of 6–12 phone calls over 1 year, delivered by a health educator, or to a comparison condition of enhanced usual care. The primary outcome is change in A1C over one year, measured at baseline and again approximately 6- and 12-months later. Secondary outcomes measured on the same schedule include blood pressure, patient-reported emotional distress, treatment adherence and self-management behaviors. A comprehensive effectiveness evaluation is guided by the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance) to gather data that can inform dissemination and implementation of the intervention, if successful. This paper describes the study rationale, trial design, and methodology. [ABSTRACT FROM AUTHOR]
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- 2020
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11. Illness perceptions and emotional well-being in men treated for localized prostate cancer
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Traeger, Lara, Penedo, Frank J., Gonzalez, Jeffrey S., Dahn, Jason R., Lechner, Suzanne C., Schneiderman, Neil, and Antoni, Michael H.
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PROSTATE cancer treatment , *PSYCHOLOGY of the sick , *EMOTIONAL state , *WELL-being , *SEXUAL dysfunction , *PSYCHOLOGICAL stress , *PATIENT compliance - Abstract
Abstract: Objective: Emotional adjustment to cancer survivorship may be influenced by how patients interpret treatment side effects and other cancer-related experiences. The current study examined cognitive representations of illness, as conceptualized by the Self-Regulatory Model (SRM), in men treated for localized prostate cancer (PC). More severe PC perceptions were hypothesized to predict poorer emotional well being, particularly among men experiencing greater post-treatment sexual dysfunction or general life stress. Methods: The Perceived Stress Scale, Expanded Prostate Cancer Index Composite, Illness Perception Questionnaire-Revised, and Functional Assessment of Cancer Therapy were administered to 214 men within 18 months of completing treatment for early stage PC. Results: Perceptions that PC was less comprehensible, was less likely to be controlled by treatment, and was more likely caused by one''s own personality and behaviors remained associated with poorer emotional well being after adjusting for relevant medical and demographic factors. Life stress moderated the relationship between perceived consequences of PC and emotional well-being, such that more severe perceptions of negative consequences predicted poorer emotional well-being only for men experiencing higher life stress. Degree of sexual dysfunction did not moderate any relationships between cancer perceptions and emotional well-being. Conclusion: Within 18 months of completing treatment for localized PC, more severe perceived consequences of PC were associated with poorer emotional well-being, particularly among men experiencing greater life stress. Interventions that target distortions in illness perceptions may enhance emotional adjustment among the most distressed PC survivors. [Copyright &y& Elsevier]
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- 2009
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12. Adults with type 2 diabetes benefit from self-management support intervention regardless of depressive symptoms.
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Mayberry, Lindsay S., Nelson, Lyndsay A., and Gonzalez, Jeffrey S.
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Aims: Elevated depressive symptoms are common among adults with type 2 diabetes (T2D). In a secondary analysis from an RCT of a diabetes self-management support intervention that did not target depressive symptoms, we sought to determine if depressive symptoms were reduced by the intervention (i.e., depressive symptoms an outcome) or, alternatively, if intervention effects on hemoglobin A1c were lesser among persons with clinically elevated depressive symptoms (i.e., depressive symptoms an effect modifier).Methods: We evaluated a text messaging intervention, REACH, in a diverse (half non-white, half underinsured) sample of N = 506 adults with T2D. Participants completed the Patient Health Questionnaire-8 (PHQ) and A1c tests at baseline and 6 months. We conducted a factor analysis to identify somatic- and cognitive-affective symptoms on the PHQ. We tested our hypotheses with regression models, using interaction terms and subgroup analyses.Results: REACH improved depressive symptoms among participants with lower baseline A1c (<8.5%; β = -0.133, p = .007; cognitive β = -0.107, p = .038; somatic β = -0.131, p = .014) but not among participants with higher baseline A1c (≥8.5%; β = 0.040, p = .468). Baseline depressive symptoms did not modify the effect on A1c.Conclusions: We found support for the hypothesis that depressive symptoms - both somatic- and cognitive-affective - may be an outcome, rather than an effect modifier, of effective diabetes self-management support interventions. [ABSTRACT FROM AUTHOR]- Published
- 2021
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13. Sexual functioning and quality of life after prostate cancer treatment: considering sexual desire
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Dahn, Jason R., Penedo, Frank J., Gonzalez, Jeffrey S., Esquiabro, Maria, Antoni, Michael H., Roos, Bernard A., and Schneiderman, Neil
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QUALITY of life , *PROSTATE cancer , *HUMAN sexuality - Abstract
: ObjectivesTo evaluate whether the relationship between sexual desire and quality of life (QOL) is moderated by sexual functioning in 91 men who had received treatment for localized prostate cancer within the past 18 months.: MethodsItems from the University of California, Los Angeles, Prostate Cancer Index and Expanded Prostate Cancer Index Composite were used to assess sexual factors, and the Functional Assessment of Cancer Therapy—General Module was administered to evaluate QOL. Education, income, and the Charlson comorbidity index were significantly related to QOL and controlled in all analyses. We tested a moderated regression model to predict QOL.: ResultsAlthough a main effect was detected for sexual functioning, the interaction of sexual desire and sexual functioning added a significant amount to the explained variance in QOL. Post hoc tests of moderation revealed that men with lower sexual functioning had significantly lower QOL scores as the level of sexual desire increased, suggesting that desire in the absence of adequate functioning may result in poorer QOL. Additionally, a tendency was found for men with better sexual functioning to have higher QOL scores as the level of sexual desire increased.: ConclusionsThe results of our study suggest that both sexual desire and sexual functioning are necessary for optimal QOL and highlight the utility of considering these two facets of sexuality independently to maximize the prediction of variance in QOL scores. [Copyright &y& Elsevier]
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- 2004
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14. Depressive symptom dimensions and medication non-adherence in suboptimally controlled type 2 diabetes.
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Hoogendoorn, Claire J., Shapira, Amit, Roy, Juan F., Walker, Elizabeth A., Cohen, Hillel W., and Gonzalez, Jeffrey S.
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TYPE 2 diabetes & psychology , *COMPARATIVE studies , *MENTAL depression , *ETHNIC groups , *FATIGUE (Physiology) , *RESEARCH methodology , *MEDICAL cooperation , *TYPE 2 diabetes , *PATIENT compliance , *QUESTIONNAIRES , *RESEARCH , *RESEARCH funding , *EVALUATION research , *TREATMENT effectiveness , *ODDS ratio - Abstract
Aims: Research suggests differential effects for somatic and cognitive-affective depressive symptoms in predicting health outcomes. This study evaluated differential relations with medication non-adherence among disadvantaged, and predominantly immigrant adults with sub-optimally controlled type 2 diabetes (T2D).Methods: Health plan members taking oral diabetes medication and who had A1c ≥ 7.5% were recruited for a trial of telephonic self-management support. A subset (n = 376; age, M = 55.6 ± 7.2 years; A1c M = 9.1% ± 1.6) completed the Patient Health Questionnaire-8 (PHQ-8). Diabetes medication adherence was measured by self-report and claims-based records. Multivariable logistic regression modeled depressive symptoms and odds of non-adherence using pre-intervention data.Results: A positive PHQ-8 screen (OR = 2.72 [95%CI: 1.56-4.73]) and each standard deviation increase in PHQ-8 score (OR = 1.40 [95%CI: 1.11-1.75]) were associated with non-adherence, with no independent effects for somatic versus cognitive-affective symptoms. Exploration of individual symptoms identified three significantly associated with non-adherence in covariate-adjusted models; after adjustment for likely presence of clinical depression, only fatigue was independently associated with non-adherence (OR = 1.71 [95%CI: 1.06-2.77]).Conclusions: Findings support depression symptom severity as a significant correlate of medication non-adherence among disadvantaged adults with T2D. Support was limited for differential associations for symptom dimensions, but findings suggest that fatigue may be associated with non-adherence independent of the likely presence of depression. [ABSTRACT FROM AUTHOR]- Published
- 2019
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15. Telephone Intervention to Improve Diabetes Control: A Randomized Trial in the New York City A1c Registry.
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Chamany, Shadi, Walker, Elizabeth A., Schechter, Clyde B., Gonzalez, Jeffrey S., Davis, Nichola J., Ortega, Felix M., Carrasco, Jeidy, Basch, Charles E., and Silver, Lynn D.
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GLYCEMIC control , *TELEPHONE in medicine , *SELF-management (Psychology) , *RANDOMIZED controlled trials , *ACQUISITION of data , *SELF-evaluation , *BLOOD sugar , *COMPARATIVE studies , *DRUGS , *GLYCOSYLATED hemoglobin , *TYPE 1 diabetes , *RESEARCH methodology , *MEDICAL cooperation , *TYPE 2 diabetes , *PATIENT compliance , *RESEARCH , *HEALTH self-care , *TELEPHONES , *EVALUATION research - Abstract
Introduction: Scalable self-management interventions are necessary to address suboptimal diabetes control, especially among minority populations. The study tested the effectiveness of a telephone behavioral intervention in improving glycemic control among adults with diabetes in the New York City A1c Registry.Design: RCT comparing a telephone intervention to print-only intervention in the context of the A1c Registry program.Setting/participants: Nine hundred forty-one adults with diabetes and hemoglobin A1c (A1c) >7% from a low-income, predominantly Latino population in the South Bronx were recruited from the A1c Registry.Intervention: All study participants were mailed print diabetes self-management materials at baseline and modest lifestyle incentives quarterly. Only the telephone participants received four calls from health educators evenly spaced over 1 year if baseline A1c was >7%-9%, or eight calls if baseline A1c was >9%. Medication adherence was the main behavioral focus and, secondarily, nutrition and exercise.Main Outcome Measures: Primary outcome was difference between two study arms in change in A1c from baseline to 1 year. Secondary outcomes included diabetes self-care activities, including self-reported medication adherence. Data were collected in 2008-2012 and analyzed in 2012-2014.Results: Participants were predominantly Latino (67.7%) or non-Latino black (28%), with 69.7% foreign-born and 55.1% Spanish-speaking. Among 694 (74%) participants with follow-up A1c, mean A1c decreased by 0.9 (SD=0.1) among the telephone group compared with 0.5 (SD=0.1) among the print-only group, a difference of 0.4 (95% CI=0.09, 0.74, p=0.01). The intervention had significant effect when baseline A1c was >9%. Both groups experienced similar improvements in self-care activities, medication adherence, and intensification.Conclusions: A telephone intervention delivered by health educators can be a clinically effective tool to improve diabetes control in diverse populations, specifically for those with worse metabolic control identified using a registry. This public health approach could be adopted by health systems supported by electronic record capabilities. CLINICALTRIALS.Gov Registration: NCT00797888. [ABSTRACT FROM AUTHOR]- Published
- 2015
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16. Memory complaints moderate the concordance between self-report and electronically monitored adherence in adults with type 2 diabetes.
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Shapira, Amit, Kane, Naomi S., Tanenbaum, Molly L., Hoogendoorn, Claire J., and Gonzalez, Jeffrey S.
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Aims: We examined the impact of memory complaints on the concordance between self-report (SR) and electronically monitored (EM) medication adherence, independent of depression symptoms, among adults with type 2 diabetes (T2D).Methods: Adults (N = 104, age = 56.6 ± 9.2; 64% female) completed a prospective and retrospective memory questionnaire (PRMQ) and a depression symptom interview at baseline. EM was tracked over 3 months and participants rated adherence using SR. Multiple linear regression evaluated PRMQ as a moderator of the relationship between EM and SR, adjusting for depression and other covariates.Results: PRMQ was correlated with lower SR (r = -0.31, p = 0.001), but not with EM. PRMQ moderated the relationship between SR and EM, independent of depression symptoms. At low levels of PRMQ, SR and EM were closely related (β = 0.76, p < 0.001); at high levels of PRMQ the relationship was weaker (β = 0.28, p = 0.02). Participants who under-reported their adherence (SR < EM) had higher PRMQ scores than more concordant reporters (p = 0.016).Conclusions: SR and EM measures were less concordant among adults with T2D who endorsed higher PRMQ scores. Memory complaints may contribute to under-reporting of medication adherence in adults with T2D. [ABSTRACT FROM AUTHOR]- Published
- 2022
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17. Depressive symptoms mediate the relationship between diabetes and cognitive performance in a community-based sample of older adults.
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Hoogendoorn, Claire J., Qin, Jiyue, Wang, Cuiling, Roque, Nelson, Laurenceau, Jean-Philippe, Katz, Mindy J., Derby, Carol A., Lipton, Richard B., and Gonzalez, Jeffrey S.
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CROSS-sectional method , *DIABETES , *COGNITION , *GERIATRIC Depression Scale , *MENTAL depression , *RESEARCH funding , *LONGITUDINAL method - Abstract
Aims: To evaluate whether diabetes and prediabetes are associated with impaired cognitive performance among older adults and examine depressive symptoms as a mediator.Methods: We used cross-sectional data from the Einstein Aging Study, a systematically recruited, community-based cohort study of diverse older adults (N = 794; Age Mean (SD) = 78.9 (5.3); 64.4% Non-Hispanic White, 28.7% Non-Hispanic Black, 5.7% Hispanic). Diabetes status was established via self-reported diagnosis, prescribed medications, and fasting blood glucose. Depressive symptoms were assessed using the Geriatric Depression Scale. Cognitive tests included Digit Symbol, Trails-B, Free Recall, Category Fluency, Boston Naming, and Block Design. Linear regression and mediation analyses were applied.Results: Compared to those without diabetes, diabetes was associated with worse performance on all cognitive tests (ps < 0.05), except Trails-B (p = 0.53), and increased depressive symptoms (p < 0.01). For diabetes, mediation via increased depressive symptoms was observed for Free Recall (p = 0.044), Category Fluency (p = 0.033), and Boston Naming (p = 0.048).Conclusions: Diabetes was consistently associated with worse cognitive performance and increased depressive symptoms among this older cohort, while prediabetes was not. Mediation findings suggest depressive symptoms may be a biobehavioral pathway linking diabetes and cognition, though the temporal sequence is unclear. If causal, addressing both diabetes and depressive symptoms among older adults may protect cognitive function. [ABSTRACT FROM AUTHOR]- Published
- 2022
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18. Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer
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Penedo, Frank J., Dahn, Jason R., Kinsinger, Dave, Antoni, Michael H., Molton, Ivan, Gonzalez, Jeffrey S., Fletcher, Mary Anne, Roos, Bernard, Carver, Charles S., and Schneiderman, Neil
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ANGER , *CELL-mediated cytotoxicity , *KILLER cells , *CANCER in men - Abstract
Abstract: Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=−.63, P<.001) and less anger suppression (β=−.29, P<.05). Furthermore, less anger suppression (β=−.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=−.29, t(56)=−2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC. [Copyright &y& Elsevier]
- Published
- 2006
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19. Study of emotional distress in a comparative effectiveness trial of diabetes treatments: Rationale and design.
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Cherrington, Andrea L., Krause-Steinrauf, Heidi, Bebu, Ionut, Naik, Aanand D., Walker, Elizabeth, Golden, Sherita H., and Gonzalez, Jeffrey S.
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PSYCHOLOGICAL distress , *DIABETES , *GLYCEMIC control , *HEALTH self-care , *TYPE 2 diabetes , *DIABETES complications - Abstract
Emotional distress, including depression and diabetes-specific distress (e.g., feeling overwhelmed by living with diabetes, feelings of failure related to diabetes self-care), is a significant and prevalent problem for patients with type 2 diabetes. Both depression and diabetes distress have been associated with metabolic/glycemic control, diabetes complications, mortality, and quality of life. Recent findings further suggest that risk for emotional distress is influenced by diabetes treatment. The GRADE Study (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is generating prospective data that will provide a unique opportunity to examine the relationships between emotional distress, diabetes treatment, and outcomes in an experimental design. The GRADE study is a randomized clinical trial that will compare the metabolic effects of four common anti-hyperglycemic drugs when combined with metformin. This sub-study recruited a subset (n = 1739) of GRADE participants and will examine patient-level variation in baseline emotional distress as a predictor of glycemic control and other health outcomes, independent of treatment effects. The study will also provide an experimental examination of treatment regimen effects on emotional distress over time as part of the overall evaluation of comparative effectiveness. Evaluation of emotional distress using validated measures will allow us to disentangle the roles of depressive symptoms and diabetes distress, factors that share significant overlap but require distinct approaches to screening and treatment. Study findings may directly influence practice decisions regarding screening and treatment for emotional distress as part of diabetes care. ClinicalTrials.gov Identifier: NCT01794143 [ABSTRACT FROM AUTHOR]
- Published
- 2021
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