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Abstract: Two new metabolites, (3S*,4S*,5S*,6R*)-4,5,6-trihydroxy-3-methyl-3,4,6,7-tetrahydro-1H-isochromen-8 (5H)-one (1) and (3R*,4S*)-7-ethyl-3,4,6,8-tetrahydroxy-3,4-dihydronaphthalen-1 (2H)-one (2), were isolated from the culture broth of the aquatic fungus Delitschia corticola YMF 1.01111, together with four known ones, 6-ethyl-7-hydroxyl-2-methoxyjuglone (3), 6-ethyl-2,7-dimethoxyjuglone (4), 6-(1-hydroxyethyl)-2,7-dimethoxyjuglone (5) and sporidesmin A (6). Structures of these compounds were elucidated mainly by NMR spectroscopic and mass spectroscopic methods. Furthermore, the antimicrobial activities of compounds 1–6 were evaluated against a panel of bacteria and fungi. [Copyright &y& Elsevier]

Abstract: Four new cycloartane triterpenoids, angustific acid A (1), angustific acid B (2), angustifodilactone A (3) and angustifodilactone B (4) were isolated from the branches of Kadsura angustifolia together with six known compounds, micranoic acid B (5), nigranoic acid (6), schisandrin (7), schisantherin D (8), interiotherin B (9), schisantherin B (10). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. Compound 1, characterized by the presence of a C-16/C-17, C-20/C-21 conjugated diene and a C-1/C-7 ester bridge formed in rings A and B, provided a novel structural skeleton for 3,4-secocycloartane triterpenoid derivatives. In addition, the anti-HIV activities of these compounds were determined in infected C8166 cells, and it was found that angustific acid A (1) exhibited the most potent anti-HIV activity with an EC50 value of 6.1μg/mL and a therapeutic index of more than 32.8. [ABSTRACT FROM AUTHOR]