1. MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia
- Author
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Gao, Xiao-ning, Lin, Ji, Gao, Li, Li, Yong-hui, Wang, Li-li, and Yu, Li
- Subjects
- *
NON-coding RNA , *GENETIC regulation , *PROTO-oncogenes , *CANCER cell proliferation , *ACUTE myeloid leukemia , *GENETIC mutation , *HEALTH outcome assessment , *LEUKEMIA etiology - Abstract
Abstract: Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML. [Copyright &y& Elsevier]
- Published
- 2011
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