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Your search keyword '"Ficzere, Máté"' showing total 10 results
Start Over Author "Ficzere, Máté" Publisher elsevier b.v.
10 results on '"Ficzere, Máté"'

10. Indirect monitoring of ultralow dose API content in continuous wet granulation and tableting by machine vision.

Author

Ficzere, Máté, Mészáros, Lilla Alexandra, Madarász, Lajos, Novák, Márk, Nagy, Zsombor Kristóf, and Galata, Dorián László

Subjects
*COMPUTER vision, *GRANULATION, *TABLETING, *VITAMIN B2, *PARTICLE analysis, *HIGH performance liquid chromatography
Abstract

[Display omitted] This paper presents new machine vision–based methods for indirect real-time quantification of ultralow drug content during continuous twin-screw wet granulation and tableting. Granulation was performed with a solution containing carvedilol (CAR) as API in the ultralow dose range (0.05 w/w% in the granule) and the addition of riboflavin (RI) as a coloured tracer. An in-line calibration in the range of 0.047–0.058 w/w% was prepared for the measurement of CAR concentration using colour analysis (CA) and particle size analysis (PSA), and the validation with HPLC resulted in respective relative errors of 2.62% and 2.30% showing great accuracy. To improve the technique, a second in-line calibration was conducted in a broader CAR concentration range of 0.039–0.063 w/w% utilizing only half the amount of RI (0.045 w/w%), while doubling the output of the granulation line to 2 kg/h, producing a relative error of 4.51% and 4.29%, respectively. Finally, it was shown that the CA technique can also be carried on to monitor the CAR content of tablets in the 42–62 μg dose range with a relative error of 5.20%. Machine vision was proven to be a potent indirect method for the in-line, determination and monitoring of ultralow API content during continuous manufacturing. [ABSTRACT FROM AUTHOR]

Published
2021
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