Search

Your search keyword '"Fernandez-Teruel, Alberto"' showing total 22 results
Start Over Author "Fernandez-Teruel, Alberto" Publisher elsevier b.v.
22 results on '"Fernandez-Teruel, Alberto"'

5. Neonatal handling enduringly decreases anxiety and stress responses and reduces hippocampus and amygdala volume in a genetic model of differential anxiety: Behavioral-volumetric associations in the Roman rat strains

Author

Río-Álamos, Cristóbal, Oliveras, Ignasi, Piludu, Maria Antonietta, Gerbolés, Cristina, Cañete, Toni, Blázquez, Gloria, Lope-Piedrafita, Silvia, Martínez-Membrives, Esther, Torrubia, Rafael, Tobeña, Adolf, and Fernández-Teruel, Alberto

Published
2017
Full Text
View/download PDF

20. Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.

Author

Wood, Christian M., Nicolas, Celine S., Choi, Sun-Lim, Roman, Erika, Nylander, Ingrid, Fernandez-Teruel, Alberto, Kiianmaa, Kalervo, Bienkowski, Przemyslaw, de Jong, Trynke R., Colombo, Giancarlo, Chastagnier, Denis, Wafford, Keith A., Collingridge, Graham L., Wildt, Sheryl J., Conway-Campbell, Becky L., Robinson, Emma S.J., and Lodge, David

Subjects
*GLUTAMATE receptors, *PHYSIOLOGICAL effects of alcohol, *NEUROLOGICAL disorders, *THERAPEUTICS, *CYSTEINE, *LABORATORY rats
Abstract

Modulation of metabotropic glutamate 2 (mGlu2) receptor function has huge potential for treating psychiatric and neurological diseases. Development of drugs acting on mGlu2 receptors depends on the development and use of translatable animal models of disease. We report here a stop codon mutation at cysteine 407 in Grm2 (cys407*) that is common in some Wistar rats. Therefore, researchers in this field need to be aware of strains with this mutation. Our genotypic survey found widespread prevalence of the mutation in commercial Wistar strains, particularly those known as Han Wistar. Such Han Wistar rats are ideal for research into the separate roles of mGlu2 and mGlu3 receptors in CNS function. Previous investigations, unknowingly using such mGlu2 receptor-lacking rats, provide insights into the role of mGlu2 receptors in behaviour. The Grm2 mutant rats, which dominate some selectively bred lines, display characteristics of altered emotionality, impulsivity and risk-related behaviours and increased voluntary alcohol intake compared with their mGlu2 receptor-competent counterparts. In addition, the data further emphasize the potential therapeutic role of mGlu2 receptors in psychiatric and neurological disease, and indicate novel methods of studying the role of mGlu2 and mGlu3 receptors. This article is part of the Special Issue entitled ‘Metabotropic Glutamate Receptors, 5 years on’. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

22. Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior.

Author

Elfving, Betina, Müller, Heidi Kaastrup, Oliveras, Ignasi, Østerbøg, Tina Becher, Rio-Alamos, Cristobal, Sanchez-Gonzalez, Ana, Tobeña, Adolf, Fernandez-Teruel, Alberto, and Aznar, Susana

Subjects
*GLUTAMATE receptors, *HUMAN behavior models, *DOPAMINE receptors, *AMPA receptors, *METHYL aspartate receptors, *PREFRONTAL cortex
Abstract

Schizophrenia is considered a neurodevelopmental disorder. Recent reports relate synaptic alterations with disease etiology. The inbred Roman High- (RHA-I) and Low- (RLA-I) Avoidance rat strains are a congenital neurobehavioral model, with the RHA-I displaying schizophrenia-related behaviors and serotonin 2A (5-HT2A) and metabotropic glutamate 2 (mGlu2) receptor alterations in the prefrontal cortex (PFC). We performed a comprehensive characterization of the RHA-I/RLA-I rats by real-time qPCR and Western blotting for 5-HT1A, 5-HT2A, mGlu2, dopamine 1 and dopamine 2 receptors (DRD1 and DRD2), AMPA receptor subunits Gria1, Gria2 and NMDA receptor subunits Grin1, Grin2a and Grin2b, as well as pre- and post-synaptic components in PFC and hippocampus (HIP). Besides corroborating decreased mGlu2 (Grm2) expression, we found increased mRNA levels for Snap25, Synaptophysin (Syp), Homer1 and Neuregulin-1 (Nrg1) in the PFC of the RHA-I and decreased expression of Vamp1, and Snapin in the HIP. We also showed alterations in Vamp1, Grin2b, Syp, Snap25 and Nrg1 at protein levels. mRNA levels of Brain Derived Neurotrophic Factor (BDNF) were increased in the PFC of the RHA-I rats, with no differences in the HIP, while BDNF protein levels were decreased in PFC and increased in HIP. To investigate the temporal dynamics of these synaptic markers during neurodevelopment, we made use of the open source BrainCloud™ dataset, and found that SYP, GRIN2B, NRG1, HOMER1, DRD1 and BDNF expression is upregulated in PFC during childhood and adolescence, suggesting a more immature neurobiological endophenotype in the RHA-I strain. • The RHA-I strain is a congenital neurobehavioral model with a schizophrenia-like phenotype. • The RHA-I strain presents a general decreased expression of the mGlu2 receptor. • This is accompanied by a decreased expression of pre- and postsynaptic markers in PFC and HIP. • This strain further presents BDNF alterations in PFC and HIP. • These genes in humans are dynamically expressed during the time-window of executive function maturation. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results