1. Endothelial dysfunction and Mid-Regional proAdrenomedullin: What role in SARS-CoV-2 infected Patients?
- Author
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Zaninotto, Martina, Mion, Monica Maria, Marchioro, Lucio, Padoan, Andrea, and Plebani, Mario
- Subjects
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SARS-CoV-2 , *ENDOTHELIUM diseases , *INTENSIVE care units , *INFECTIOUS disease transmission , *C-reactive protein , *COVID-19 - Abstract
• To evaluate in SARS-CoV-2 patients the behavior of MR-proADM a peptide derived from adromedullin, that maintains endothelial integrity: the endothelial dysfunction seems to be involved in the spread of the COVID-19 disease and, consequently, the increase in this biomarker concentrations allow to obtain clinically relevant prognostic informations. • To compare the informations provided by MR-proADM with those of some biomarkers routinely measured in patients suffering from multiorgan disease. • To provide additional biochemical informations in patients suffering from SARS-CoV-2 producing an outbreak of pandemic proportions. Endothelial dysfunction, a major complication of SARS-CoV-2 infectionplaying a key-role in multi-organ damage, carries high risk of mortality. To investigate the potential role of Mid-Regional pro-Adrenomedullin (MR-proADM) in detecting endothelial damage with a view to stratifying the risk of adverse events (length of stay, death, admission in Intensive Care Unit) and/or disease resolution. In 135 consecutive patients with SARS-CoV-2 infection, MR-proADM was measured in EDTA-K2 plasma samples using B.R.A.H.M.S. KRYPTOR® COMPACT Plus method (Thermo Fisher Scientific, Hennigsdorf, Germany) Patients were subdivided into three groups based on their MR-proADM value (nmol/L): 1 (n = 20, MR-proADM ≤ 0.55); 2 (n = 82, 0.55 < MR-proADM ≤ 1.50); 3 (n = 33, MR-proADM > 1.50). The higher the MR-proADM value, the greater the patients' age, the more frequent the occurrence of pneumonia, the requiring of more aggressive treatment, the longer the hospitalization and the more frequent a fatal event. Significant differences were found between the three groups for MR-proADM, White-blood cell count, Neutrophil count, D-dimer, C-reactive Protein, Procalcitonin and hs-Troponin I. At logistic regression,it was found that MR-proADM and Log 10 D-dimer were the most significant predictors of adverse events. The findings made in the present study highlight the relevance of MR-proADM values in providing clinically useful information, particularly for stratifying COVID-19 patients according to the risk of a more severe form of disease and to the development of adverse events. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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